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<h4>Background</h4>Identifying safe and broad-spectrum antiviral and anti-inflammatory agents remains an urgent need in infectious and inflammatory diseases. Here, we demonstrated that MNS (NSC170724), a small-molecule nitrovinyl benzodioxole, enhanced antiviral defense while limiting excessive inflammation.<h4>Methods</h4>The antiviral …
Read PDFTransposable elements (TEs) comprise nearly half of mammalian genomes and drive species-specific regulatory innovation, but their contributions to the first lineage segregation-establishing trophectoderm versus inner cell mass (ICM)-remain largely unexplored. Here, we identify IAPEz, a …
Read PDFParkinson's disease (PD) involves selective degeneration of midbrain dopaminergic neurons (mDANs), yet the regulatory networks governing their development remain incompletely understood. ZFHX4 has been linked to neurodevelopment across species and shows reduced expression in the …
Read PDFKDM5B, a member of the KDM5 family of histone demethylases, plays a critical role in transcriptional repression by demethylating H3K4me2/3. It regulates key biological processes such as development, stem cell maintenance, and oncogenesis, and its …
Read PDFEpigenetic regulation is a key determinant of adipocyte fate, driving the differentiation toward white or thermogenic beige phenotypes in response to environmental cues. To dissect the mechanisms orchestrating this plasticity in human adipocytes, we conducted …
Read PDFNeurofibromatosis Type 1 (NF1) predisposes to peripheral nerve tumor development. The progression from a benign plexiform neurofibroma (PNF) towards a deadly malignant peripheral nerve sheath tumor (MPNST) is not completely understood but commonly involves the …
Read PDFChromatin looping by CTCF and cohesin is thought to be crucial for chromosome organization and gene transcription. Yet the precise relationships between CTCF, cohesin, and transcription in neurons are still poorly understood. To address this …
Read PDFUnderstanding transcriptional regulatory networks (TRNs) in microglia is essential for elucidating mechanisms underlying central nervous system (CNS) disorders. Human induced pluripotent stem cell (iPSC)-derived models enable mechanistic studies of microglia but often suffer from variability …
Read PDFCancer progression involves extensive alterations in epigenetic and gene expression programs, but the accompanying changes in higher-order genome organization remain less well understood. Using high-resolution Micro-C mapping in the MCF10 cell model of breast cancer, …
Read PDF<h4>Background</h4>We investigate the flow of genetic information from DNA to RNA to protein as described by the Central Dogma in molecular biology, to determine the impact of intermediate genomic levels on plant protein expression.<h4>Results</h4>We perform …
Read PDFThe amount of soluble inorganic phosphate (Pi) in soils is typically low and limiting plant growth. Roots of trees in several forest ecosystems form association with ectomycorrhizal (ECM) fungi, where fungi forage and supply inorganic …
Read PDFBACKGROUND: Mammary gland development and lactation are dynamic biological processes governed by coordinated changes in chromatin accessibility and gene expression. RESULTS: We performed paired ATAC-seq and RNA-seq profiling to characterize stage-associated chromatin accessibility and transcriptional …
Read PDFA plethora of factors contribute to cognitive impairment in Alzheimer's disease (AD), including neuroinflammation, synaptic dysfunction and gene alteration. In search of transcription factors controlling dysregulated genes in AD, we identified that the histone demethylase …
Read PDFMaintenance of pluripotency is a multifactorial process in which NF-κB is a negative regulator. Our previous work identified a chromatin role for IκBα, the master regulator of NF-κB signaling, that is critical for the proper …
Read PDF<i>Plasmodium falciparum</i> is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired, but this is disrupted when …
Read PDF<h4>Background</h4>Sézary syndrome (SS) is an aggressive and leukemic variant of Cutaneous T-cell Lymphoma (CTCL) with an incidence of 1 case per million people per year. It is characterized by a complex and heterogeneous profile of …
Read PDF<h4>Introduction</h4>Tomato yellow leaf curl virus (TYLCV, <i>Begomovirus coheni</i>), a whitefly-transmitted begomovirus, causes serious economic losses to tomato crops globally. Over the past three decades, several genetic sources of TYLCV resistance have been identified and incorporated …
Read PDFIL-1β-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inhibitor-induced inflammatory arthritis (ICI-arthritis), and pancreatic cancer and proposed to be pathogenic. IL-1β+ macrophages express genes cooperatively induced by PGE2 and TNF signaling, but …
Read PDFChromatin within the nucleus adopts complex three-dimensional structures that are crucial for gene regulation and cellular function. Recent studies have revealed the presence of distinct chromatin subcompartments beyond the traditional A/B compartments (eu- and hetero-chromatin), …
Read PDFDuring spermatogenesis, extensive chromatin remodeling and histone replacement reshape the male germline epigenome. Although HIRA mediates transcription-coupled incorporation of histone variant H3.3, we identified DAXX as a key histone chaperone directing genome-wide, transcription-coupled replacement of …
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