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Nanopore sequencing enables the simultaneous detection of genetic sequences and DNA modifications, yet the development of accurate, open-source computational models for these tasks, particularly for non-ONT platforms, remains challenging. To address this, we developed Bream, …
Read PDF<h4>Motivation</h4>In prokaryotic genomes, methylation is an important epigenetic modification that regulates the uptake of foreign DNA; it can also contribute to replication or virulence. We present MPore, a novel method for the database-driven detection of …
Read PDF<h4>Motivation</h4>DNA methylation serves as a key biomarker in clinical diagnostics, especially in cancer detection. With methylation-specific PCR (MSP), a widely used approach, patient samples can be screened fast and efficiently for differential methylation. During MSP, …
Read PDF<h4>Absrtact</h4>Plecoptera (stoneflies) are hemimetabolous insects of significant ecological importance in freshwater ecosystems and are key to understanding early insect diversification and aquatic adaptation. Here, we present a high-quality, chromosome-level reference genome assembly for Indonemoura scalprata …
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