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The superfamily Nemouroidea (Plecoptera) represents one of the most diverse and ecologically significant groups of stoneflies, with nymphs serving as crucial bioindicators of freshwater ecosystem health due to their sensitivity to water quality. However, the …
Read PDFPiptanthus nepalensis (Hook.) Sweet is a leguminous shrub native to the Himalayan region and is valued for its medicinal uses and ornamental yellow flowers. Here, we report a chromosome-scale genome assembly of P. nepalensis generated …
Read PDFThe Blue-crowned Laughingthrush (Pterorhinus courtoisi) is a critically endangered species and listed as National First-class Protected Wildlife in China, with a small population size and highly restricted geographic distribution in Jiangxi Province. However, the genetic …
Read PDF<h4>Motivation</h4>Short-read sequencing data can be affected by alignment artifacts in certain genomic regions. Removing reads overlapping these exclusion regions, previously known as Blacklists, help to potentially improve biological signal. Alternatively, "sponge" or decoy sequences have …
Read PDFThe Leschenault's rousette (Rousettus leschenaultii) represents a medium-sized bat of the genus Rousettus that feeds on fruits or flowers, mainly distributed in Southeast Asia. Here, we generated a chromosome-level genome assembly of R. leschenaultii using …
Read PDF<b>Background:</b> Cognitive and psychiatric disorders are caused by a complex interplay between genetic predisposition, environmental exposures, and dynamic molecular regulation in the brain. Animal models provide a controlled environment for examining these mechanisms, and advances …
Read PDFGastric cancer (GC) remains a major global health burden, with its unfavorable prognosis primarily driven by extensive tumor heterogeneity. Traditional bulk omics, while informative, are inherently limited by the averaging effect of diverse cell populations …
Read PDFGastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved …
Read PDFNeurodegenerative diseases are characterized by protein misfolding and the selective vulnerability of specific neuronal subtypes. This selective vulnerability presents a paradox; most neurodegenerative disease genes are expressed broadly throughout the brain, and some ubiquitously, but …
Read PDFImmune checkpoint inhibitors have become integral to the management of non-small cell lung cancer (NSCLC), yet both primary and acquired resistance remain frequent and are only partially captured by routine biomarkers such as programmed death-ligand …
Read PDF<i>N</i>-Nitrosodimethylamine (NDMA), a probable human carcinogen, induces toxic and mutagenic DNA <i>O</i> <sup>6</sup>-methylguanine (<i>O</i> <sup>6</sup>MeG) adducts that are repaired by <i>O</i> <sup>6</sup>-methylguanine-DNA methyltransferase (MGMT). To elucidate how early-life environmental mutagenic exposures promote latent liver tumorigenesis, …
Read PDF<h4>Purpose of review</h4>This review examines the limitations of conventional macroscopic approaches in detecting occult cervical lymph node metastasis (OCLNM). It also explores how multi-omics technologies and artificial intelligence (AI) driven cross-scale multimodal integration are reshaping …
Read PDF<h4>Background/purpose</h4>Multi-omics integration linking genomic, transcriptomic, epigenomic, proteomic, metabolomic, single-cell, and spatial data has transformed the interpretation of human genetic variation by capturing molecular processes that extend beyond DNA sequence alone. Although these approaches substantially improve …
Read PDF<h4>Objectives</h4>To evaluate the contribution of OMICS technologies to the understanding of peri-implantitis pathogenesis from a host immune perspective.<h4>Materials and methods</h4>A narrative review was conducted based on electronic searches of PubMed, MEDLINE, and Google Scholar up …
Read PDFSeeds provide 70% of the global food supply, making them crucial for food security. Understanding the molecular mechanisms governing seed development, dormancy, and germination has become increasingly urgent as climate change impacts crop productivity. Over …
Read PDFChina has rich bamboo resources, with Moso bamboo (<i>Phyllostachys edulis</i>) being the most economically important species. Bamboo shoot bud development directly determines the eating quality of the shoots and the properties of bamboo materials; however, …
Read PDFSingle-cell and spatial transcriptomics have revolutionized studies of symbiotic nitrogen fixation by resolving cellular heterogeneity, spatial gene-expression, and regulatory dynamics within root nodules. Recent investigations in model legumes have revealed conserved and species-specific programs controlling …
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