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<h4>Background</h4>Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational modification process known as ISGylation.<h4>Objective</h4>In this study, the role …
Read PDFBACKGROUND: Celiac disease (CeD) is an autoimmune disease triggered by dietary gluten in genetically predisposed individuals. Deamidation of gluten peptides by the CeD autoantigen and enzyme transglutaminase 2 (TG2) is central to the pathogenesis of …
Read PDFThe aim of this study was to investigate the generation pathways of volatile substances derived from protein degradation in tilapia fillets stored at 4 °C, using Astral DIA proteomics. Seventeen key volatile substances were identified …
Read PDF<h4>Background</h4>The molecular determinants for lung graft-<i>versus</i>-host disease-associated bronchiolitis obliterans syndrome (BOS) are poorly understood, and biomarkers in children following haematopoietic stem cell transplant do not exist. To address this gap, we analysed plasma samples from …
Read PDF<h4>Introduction</h4>The effects of aerobic physical activity on proteolysis-related markers of cardiovascular, kidney, and endothelial dysfunction, such as asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), have not been well studied. Our goal was to investigate the …
Read PDFUnderstanding region-specific proteoform profiles in the brain is crucial for deciphering neural function and identifying therapeutic targets. Zebrafish (Danio rerio) is a valuable vertebrate model for neuroscience research due to its substantial conservation of brain …
Read PDFThe accuracy of crucial nuclear processes such as transcription, replication, and repair depends on the local composition of chromatin and the regulatory proteins that reside there. Understanding these DNA-protein interactions at the level of specific …
Read PDFO-linked β-<i>N</i>-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) underlies the pathogenesis of multiple cancers, including hepatocellular carcinoma (HCC). However, comprehensive and quantitative characterization of site-specific O-GlcNAcylation at the proteome scale remains technically challenging. Here, we employed an integrated …
Read PDFGallbladder cancer (GBC) is an aggressive malignancy with limited treatment options. ω-3PUFAs have known anticancer activity, but their role in GBC remains unclear. The anti-GBC effects of ω-3PUFAs (DHA/EPA) were evaluated using in vitro assays …
Read PDF<h4>Background</h4>Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of compounds derived from traditional Chinese medicine remains insufficiently characterized. …
Read PDFThe correct tools for characterization of histone proteoforms are essential for deciphering plant epigenetic mechanisms and their subsequent application in biotechnology. Insights into the epigenetic landscape of plant chromatin can be advanced using bottom-up proteomics. …
Read PDFAging is one of the most complex biological processes, which leads to a gradual decline in the function of organs, tissues and cells, and significant increases in the risks of many age-associated diseases, including cancer, …
Read PDF<h4>Background</h4>Postoperative delirium (POD) is a frequent and serious complication in older surgical patients, characterized by acute cognitive dysfunction and fluctuating levels of consciousness. POD is associated with prolonged hospitalization, long-term cognitive decline, reduced quality of …
Read PDFIdentifying the proteins that interact with sequence-defined chromatin segments is a critical step in understanding gene expression. Most procedures perform bulk analysis of samples to identify the general interactions that occur in a cellular population …
Read PDFTransthyretin amyloidosis (ATTR) is a progressive disease characterized by systemic deposition of transthyretin-derived amyloid. Although the recent advent of disease-modifying therapies has expanded treatment options, substantial unmet needs remain, such as understanding disease heterogeneity, predicting …
Read PDFClear cell renal cell carcinoma (ccRCC) is characterized by a complex molecular landscape driven by recurrent genetic alterations. While genomic and transcriptomic profiling have identified core drivers, they often fail to provide robust biomarkers due …
Read PDFMyelodysplastic neoplasms (MDS) are clonal hematopoietic disorders defined by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia. Although genomic and epigenomic studies have provided insight into disease pathogenesis, reliable biomarkers for …
Read PDF<h4>Introduction</h4>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by behavioral impairments and limited therapeutic options. Emerging evidence suggests that plant-derived polyphenols may offer neuroprotective benefits.<h4>Objectives</h4>This pilot study aimed to investigate the therapeutic potential of …
Read PDFHeart specialization involves nuclear programs; however, chamber-specific regulation of the nuclear proteome landscape remains unknown. In this study, we isolated the nucleus from four major anatomical regions of healthy mouse heart (fresh) and employed quantitative …
Read PDF<h4>Aims</h4>Incomplete penetrance is common in genetic cardiomyopathy, but poorly understood. Here, we investigate the circulating molecular signature in a cohort of patients with one specific phospholamban (PLN) p.Arg14del (R14del, R14Δ/+) pathogenic variant underlying R14Δ/+ cardiomyopathy …
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