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Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or sensitive …
Read PDFZygotes inherit parental genomes with distinct chromatin structures. In eutherian mammals, this asymmetry is considered crucial for embryonic development, notably because it enables genomic imprinting. Besides the well-established role of DNA methylation in this process, …
Read PDFChemotherapy resistance remains a critical barrier in cancer treatment, partly driven by polyploid cells that survive therapy and contribute to tumor recurrence. Here, we investigated epigenomic and transcriptional changes associated with cisplatin-surviving polyploid cells compared …
Read PDFThe transcription factor Sex-determining region Y-box protein 3 (SOX3) is well known for its critical roles in sex determination and cell differentiation; however, its function in antiviral innate immunity remains unexplored. This study uncovered how …
Read PDFChromatin modifications are essential for mammalian development, and their aberrant deposition is associated with human disease. While the mechanisms that deposit and remove histone modifications have been largely elucidated, their roles in regulating gene activity …
Read PDFSome methanotrophs synthesize S-layers that overlay their outer membrane. Transmission electron microscopy imaging revealed that <i>Methylomicrobium album</i> BG8 constitutively sheds abundant S-layer units, a phenotype not found in seven other methanotrophs, even though <i>Methylotuvimicrobium buryatense</i> …
Read PDFColorectal cancer is initiated by loss of APC, which drives expansion of LGR5+ intestinal stem cell (ISC) populations. Whilst LGR5 + ISC expansion is a critical step for tumour initiation and progression, its regulation is …
Read PDF<h4>Objective</h4>To determine whether baseline epigenomic and transcriptional profiles of human dental pulp stem cells (DPSCs) differ by sex, and to assess sex dependence of key markers related to growth and stemness.<h4>Methods</h4>Primary DPSCs from nine young …
Read PDFThe ability of cancer cells to promote cellular proliferation by preferentially using glycolysis as primary source of energy has long been considered a hallmark of tumour metabolism. However, emerging evidence suggests a more complex situation …
Read PDFIdentifying and functionally validating the causal variants at genome-wide association study (GWAS) loci is very challenging and has only been achieved for very few variants. Here, we validate a single-nucleotide polymorphism (SNP) associated with increased …
Read PDFAs the use of immune checkpoint inhibitors for the treatment of cancer has expanded, convincing data have emerged correlating active WNT signaling with resistance to immunotherapies. To identify mechanisms through which WNT signaling limits anti-tumor …
Read PDF<h4>Introduction</h4>Systemic Lupus Erythematosus (SLE) exhibits a pronounced sex bias, affecting females approximately nine times more frequently than males; however, males tend to experience a more severe clinical course yet the molecular basis for these differences …
Read PDFEndophytic bacteria contribute to plant growth, stress tolerance, and pathogen resistance. Their effective use in agriculture requires the identification of strains that combine multiple beneficial traits with consistent performance across different field conditions. Accordingly, this …
Read PDFLilies are popular ornamental and medicinal plants with gigantic genomes. Due to the challenge of assembling complex giga-genomes, our understanding of the genetic architecture, epigenetic regulation and evolution of large-genome plants such as lily remains …
Read PDFSince their discovery, the phylogenetic placement of the extremely halophilic, methanogenic <i>Methanonatronarchaeia</i> has remained controversial. Different studies have variably placed this lineage as sister to the archaeal class <i>Halobacteria</i> (haloarchaea) or as a deep-branching euryarchaeal …
Read PDF<i>Avicennia marina</i>, commonly known as the grey mangrove, is a salt-tolerant species widely distributed in coastal and estuarine ecosystems. Traditionally, it has been used in folk medicine to treat skin diseases, rheumatism, and ulcers due …
Read PDF<h4>Main conclusion</h4>The high-quality L. discolor genome clarifies orchid phylogeny and provides immediate targets for breeding and biosynthetic engineering of medicinal metabolites. Ludisia discolor is a valued orchid for ornamental veined foliage and documented medicinal uses, …
Read PDFClonorchis sinensis, a common food-borne liver fluke in East Asia, is a Group 1 carcinogen strongly linked to cholangiocarcinoma. In recent years, molecular biology and multi-omics studies have revealed that this parasite drives chronic inflammation …
Read PDFCardiovascular diseases (CVDs) rank among the most prevalent conditions globally, encompassing coronary heart disease, hypertension, cardiomyopathy, and heart failure. The global prevalence of CVD continues to rise despite available therapies such as interventional procedures and …
Read PDF<h4>Background/objectives</h4>Melanoma is one of the deadliest types of skin cancer due to its ability to metastasize if not treated early. While targeted- and immune- therapies have significantly improved melanoma treatment outcomes, acquired drug resistance even …
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