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Metabolic-epigenetic coupling is recognized as a central hallmark of malignant transformation, characterized by dynamic interplay between cellular metabolism and epigenetic regulation. Cancer cells undergo metabolic reprogramming to meet new demands due to increased biosynthesis and …
Read PDFIn a recent paper published in Nature Communications, Dai and colleagues offer a practical re-engineering of a workhorse: ultra-mild bisulphite sequencing (UMBS-seq), which re-tunes classical bisulphite conversion so that fragmented, low-input clinical DNA can yield …
Read PDFMethylomics has emerged as a central framework for understanding gene regulation in development and disease, yet the rapid expansion of profiling technologies, computational integration methods, and clinical applications has outpaced comprehensive synthesis. This review addresses …
Read PDFRapid methodological breakthroughs over the past ten years have transformed epigenomics from bulk, population-averaged assays into single-cell, multi-omic, and intracellular spatial investigations. This review surveys the interconnected technology pillars that now map the epigenome with …
Read PDFMoyamoya disease (MMD) is a rare, progressive cerebrovascular disorder characterized by internal carotid artery stenosis and compensatory vascular network formation. While its pathogenesis remains unclear, multi-omics approaches provide crucial molecular insights. Genomic studies identify significant …
Read PDFAlzheimer's disease (AD) and related dementias (ADRD) are neurodegenerative conditions that cause gradual deterioration of cognition, memory and language in the elderly. AD has been declared as a health priority by the World Health Organization …
Read PDFComplex diseases driven by gene-environment interactions impose a heavy burden on human and animal health. Addressing these challenges requires innovative research. The emerging field of historical epigenomics offers a promising opportunity to link genotypes with …
Read PDFDNA methylation is an epigenetic regulator of gene expression and cell identity, which can be shaped by both physiological and pathological factors, including environmental exposure. The identification of sites with high methylation variability can be …
Read PDFPreeclampsia (PE) remains a major contributor of maternal and fetal morbidity and mortality worldwide, affecting 2%-8% of pregnancies. While genetic predisposition, placental dysfunction, and angiogenic imbalance remain central to PE pathophysiology, emerging observational evidence suggests …
Read PDFThe 48th Annual Meeting and International Conference of the Environmental Mutagen Society of India (EMSI) on 'Environmental Mutagenesis & Epigenomics in Relation to Human Health' was held at Jamshedpur Co-Operative College, in association with Kolhan …
Read PDF<h4>Background</h4>Symptoms following SARS-CoV-2 infection, referred to as Long-COVID, have been reported since the pandemic. We investigated whether COVID-19 or Long-COVID is associated with persistent genome-wide DNA methylation (DNAm) changes in whole blood using a longitudinal …
Read PDF<h4>Background</h4>Childhood trauma is associated with increased risk of depression and epigenetic alterations in stress-related pathways. Preclinical studies suggest that methyl donors may facilitate DNA methylation changes. This first-in-human trial of epigenetic treatment investigated methyl donor …
Read PDFThe prevailing paradigm in aesthetic medicine is the "antiaging" model, which focuses on correcting and/or reversing visible signs of aging. However, contemporary geroscience reconceptualizes aging as a malleable biological process driven by defined hallmarks, offering …
Read PDFThis exploratory study investigated the interactive effects of dietary fat content and methyl-donor supplementation on genome-wide DNA methylation in adipose tissue of female lupus-prone NZBWF1/J mice. Thirty mice were randomly assigned to four groups for …
Read PDFHigh-throughput single-cell sequencing is widely used to study cell identity. We present SEAGALL (Single-cell Explainable Geometry-Aware Graph Attention Learning pipeLine), a deep learning method to quantify the impact of molecular features on cellular phenotype, based …
Read PDF<h4>Objective</h4>To define neurovascular ecosystem states within the tumor microenvironment and elucidate the regulatory basis of cerebrovascular remodeling through single-cell multi-omics and interpretable machine learning.<h4>Methods</h4>An orthotopic murine brain tumor model was established. Single-cell RNA sequencing (scRNA-seq), …
Read PDFObesity impairs subcutaneous adipose tissue function, which predisposes to chronic cardiometabolic comorbidities and accelerated biological aging. However, regulatory variants, their target genes and epigenomic landscape underlying this predisposition in each subcutaneous adipose tissue cell-type remain …
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Read PDFLegumes are important food crops and play a central role in sustainable agriculture through their ability to form symbiosis with rhizobia, soil bacteria that fix atmospheric nitrogen. Recent advances in single-cell and spatial transcriptomics, along …
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