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Pesticides are widely used in rice cultivation for pest control to guarantee crop productivity. Intensive use of these chemicals causes harmful effects on rice plants, such as physiological and biochemical stress responses. Such stress is …
Read PDF<h4>Aims</h4>To examine the relationship between DNA methylation of <i>NR3C1</i> exon 1F and <i>HSD11B2</i> promoters and neurodevelopment, and oral feeding skills in preterm infants.<h4>Design</h4>A longitudinal prospective cohort study was conducted.<h4>Methods</h4>Data from 61 preterm infants who were …
Read PDFSingle-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) profiles chromatin accessibility at cellular resolution, making it possible to reveal epigenomic landscapes that govern gene regulation in a variety of cells. Nevertheless, heterogeneous feature spaces and …
Read PDFThis multi-omics cross-sectional study investigated differences in metabolomics, proteomics, and epigenomics profiles between two groups of adults matched for age but differing in lifestyle factors such as body composition, diet, and physical activity patterns. Data …
Read PDFThe common missense variant rs1126809 in the <i>TYR</i> gene, encoding a key enzyme in melanin synthesis, is linked to both albinism and melanoma susceptibility. Although its role in hypopigmentation as part of a risk haplotype …
Read PDFIn some crosses, the hybrid progeny perform better than their parental inbred lines in terms of beneficial traits (e.g., greater biomass, faster development), a phenomenon known as hybrid vigor or heterosis. While classical genetic paradigms …
Read PDFAcute myeloid leukemia (AML) is a highly heterogeneous and aggressive hematologic malignancy characterized by clonal proliferation of myeloid precursors. Despite significant advancements in genomic profiling and targeted therapies, patient outcomes remain suboptimal due to disease …
Read PDFGenomic imprinting is a phenomenon in which one parental allele is silenced epigenetically. My research has focused on the role of epigenetics in human health and disease since 1995 when we identified the first tumor …
Read PDFThe introduction of the term pituitary neuroendocrine tumor (PitNET) to replace pituitary adenoma has sparked a versatile debate among experts. The controversy surrounding this nomenclature change includes the question of whether these tumors' biological identity …
Read PDFEpigenetic reprogramming during gametogenesis and early embryogenesis involves genome-wide erasure and re-establishment of DNA methylation, ensuring developmental plasticity. However, specific genomic regions, such as imprinted loci and transposable elements, can escape this reprogramming, allowing environmentally …
Read PDFChronic Kidney Disease (CKD) is a progressive condition characterized by the gradual loss of renal function over time, affecting millions worldwide and representing a significant public health challenge. CKD is associated with increased morbidity and …
Read PDFForages are essential to global agriculture and ecosystems, with the development of high-yield, high-quality varieties as a cornerstone of efficient agricultural practices. However, traditional genetic breeding methods, characterized by lengthy cycles and limited efficiency, fall …
Read PDF<h4>Background</h4>Gliomas are the most common malignant brain tumors in adults, characterized by a poor prognosis. Although the current World Health Organization (WHO) classification provides clear guidelines for classifying oligodendroglioma, astrocytoma, and glioblastoma patients, significant heterogeneity …
Read PDFAutoimmune diseases (ADs) exhibit complex heterogeneity and dynamic pathological mechanisms. Traditional biomarkers face numerous challenges in the diagnosis and treatment of ADs. However, the rapid development of multi-omics technologies and bioinformatics has not only deepened …
Read PDFThe mechanisms regulating transcriptional changes during brain aging remain poorly understood. Here, we use single-cell epigenomics to profile chromatin accessibility and gene expression across eight mouse brain regions at 2, 9, and 18 months of …
Read PDFBone marrow biopsy remains central to the diagnosis, classification, and monitoring of hematologic disorders, providing essential morphologic and immunophenotypic information. However, conventional assessment is limited by interobserver variability and an inability to fully capture the …
Read PDFIn recent years, major psychiatric disorders have been intensively researched. Studies have investigated the pathophysiology of these disorders in detail and at various molecular levels with several omics techniques, including genomics, epigenomics, transcriptomics, proteomics, and …
Read PDFThe adoption of liquid biopsy approaches in clinical practice has triggered a significant paradigm shift in the diagnostic, prognostic, and predictive outcomes for cancer patients. Circulating tumor DNA (ctDNA) is considered a valuable biomarker for …
Read PDFThis review presents an overview of the emerging roles of epigenomic regulation in immune cell function, with a particular focus on its relevance in inflammatory bowel diseases (IBD). Epigenetic mechanisms, including DNA methylation, histone modification, …
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