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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by a complex interplay of molecular factors. Despite advances in understanding its pathophysiology, diagnostic delays and the absence of personalized treatment strategies remain significant challenges. This …
Read PDFThe incidence of locally advanced rectal cancer (LARC) among young people is rising alarmingly. In recent years, new protocols have been introduced for the management of LARC, some of which are associated with the risk …
Read PDFDuring cortical development, neural stem cells (NSCs) combine self-renewal with the sequential production of different subtypes of projection neurons as well as glia cells. How the NSC epigenome accommodates this over time remains unresolved. Here, …
Read PDF<h4>Background</h4>Non-small cell lung cancer (NSCLC) involves complex alterations in the epidermal growth factor receptor (EGFR) signaling pathway. This study aims to integrate multimodal omics analyses to evaluate and enhance EGFR-targeted therapies.<h4>Methods</h4>We reviewed and synthesized omics …
Read PDF<b>The</b> World Health Organization identifies environmental pollution as a primary global health threat, and its role in the onset and progression of neurological diseases is becoming increasingly clear. In the era of precision medicine, understanding …
Read PDFChromatin immunoprecipitation sequencing (ChIP-seq) is a widely used technique for identifying transcription-factor binding and histone modifications across the genome. Peaks in ChIP-seq data vary in length depending on the biological context, from narrow transcription factor …
Read PDF<h4>Background</h4>While height is a highly heritable trait with strong polygenic prediction, previous studies have postulated that minimal variation of its individual differences can be captured by DNA methylation (DNAm). We investigated the role of blood-based …
Read PDFThe convergence of high-resolution multi-omics technologies with computational systems biology is transforming plant physiology by enabling predictive, mechanistic, and field-relevant insights into crop performance, adaptation, and resilience. This review presents an integrative and forward-looking synthesis …
Read PDFExperimental models and epidemiological data suggest that environmental factors, for example, adverse nutrition prior to conception, can lead to phenotypes in offspring of exposed parents in the absence of continued exposure. As a result these …
Read PDF<h4>Motivation</h4>Early prediction of Alzheimer's disease (AD) progression from mild cognitive impairment (MCI) remains a major challenge, particularly when relying on non-invasive biomarkers. Identifying individuals with progressive MCI (pMCI) before conversion to AD could improve intervention …
Read PDFThe preview discusses the scalable platform for methylation-based trait mapping published in Cell Genomics by Goldberg et al.<sup>1</sup> This work represents not only a methodological advance but also marks a conceptual shift toward scalable and …
Read PDFThe retina is a highly specialized neural tissue characterized by extreme cellular differentiation, high metabolic demand, and lifelong exposure to environmental stressors. These features render retinal cell identity exquisitely dependent on epigenetic regulation of gene …
Read PDFEpigenetics, the study of heritable changes in gene expression that do not involve alterations to the DNA sequence, has emerged as a transformative field in biology and medicine, revealing how gene expression is modulated in …
Read PDF<h4>Background</h4>Preterm birth and very low birth weight (VLBW; <1500 g) increase risks for poor health outcomes, potentially mediated by epigenetic modifications such as DNA methylation (DNAm). We hypothesized that DNAm differs between VLBW adults and …
Read PDFEpigenetic heterogeneity is a fundamental property of biological systems and is recognized as a potential driver of tumor plasticity and therapy resistance. Single-cell epigenomics technologies have been widely employed to study epigenetic variation between-but not …
Read PDFThis review summarises evidence from cohort and intervention studies on the relationships between nutrition in early life, epigenetics and lifelong health. Established links include maternal diet quality with conception rates, micronutrient sufficiency before and during …
Read PDF<h4>Aims</h4>Mitochondrial DNA copy number (mtDNA-CN) is associated with several age-related chronic diseases and is a predictor of all-cause mortality. Here, we examine site-specific differential nuclear DNA (nDNA) methylation and differential gene expression resulting from in …
Read PDFGenomic imprinting is an epigenetic occurrence that results in the expression of alleles specific to the parent of origin, plays pivotal roles in plant development, stress adaptation, and agronomic trait regulation. While imprinting has been …
Read PDF<h4>Objective</h4>Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the …
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