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<h4>Background</h4>Precision cancer risk stratification for gastric cancer is urgently needed for the growing number of healthy people after <i>Helicobacter pylori</i> eradication. The epimutation burden in non-malignant tissues has been associated with cancer risk in multiple …
Read PDF<h4>Background</h4>Epigenetics in cancer has been a focus of intense research in the recent years. This phenomenon has attracted great interest because it offers potential targets for cancer therapy. To capture the intellectual landscape of this …
Read PDF<h4>Aims</h4>Metabolic syndrome (MetS) is a composite disorder that includes abdominal obesity, impaired glucose levels, high blood pressure, and dyslipidemia. Smoking can alter epigenetic profiles and is a critical modifiable risk factor for MetS. We aim …
Read PDFImproving economically important traits such as productivity, fertility, and health remains a central goal in modern cattle breeding. While genome-wide association studies (GWAS) have revolutionized genomics by identifying numerous trait-associated single nucleotide polymorphisms (SNPs), a …
Read PDF<h4>Aims & methods</h4>DNA methylation and genomic instability are critical drivers of cancer initiation and malignant progression. However, the roles of methylation aberrations and genomic instability in malignant progression have not been thoroughly investigated in intrahepatic …
Read PDF<h4>Objective</h4>This in vitro study aimed to investigate the impact of folic acid on DNA methylation and gene expression in adipocytes from subcutaneous adipose tissue of patients with systemic lupus erythematosus (SLE), with a focus on …
Read PDF<b>Background/Objectives</b>: Epigenetic clocks have emerged as a tool to quantify biological age, providing a more accurate estimate of an individual's health status than chronological age, helping to identify risk factors for accelerated aging and evaluating …
Read PDF<h4>Introduction</h4>Preterm birth is a significant contributor to pregnancy-related morbidity and mortality, particularly affecting black women. Racism is a key driver of perinatal inequities, but mechanisms remain unclear. Epigenomics research offers promise in understanding how environmental …
Read PDFThe integration of genetic and epigenetic information is essential for a comprehensive understanding of genome function and regulation. Traditional sequencing methods often fall short in capturing both genetic variants and epigenetic modifications such as 5-methylcytosine …
Read PDF<h4>Background</h4>Social epigenomics research investigates links between social experiences and epigenetic modifications, which may ultimately impact health. Such research holds promise for precision medicine and addressing health disparities based on social conditions, but also brings unique …
Read PDF<h4>Aims</h4>Adverse childhood experiences (ACEs), especially in early life, can affect psychosocial development and increase lifelong risk for mental disorders. ACEs are also known to induce persistent epigenetic changes. This study aimed to explore ACE-associated DNA …
Read PDFWe introduce ChromActivity, a computational framework for predicting and annotating regulatory activity across the genome through integration of multiple epigenomic maps and various functional characterization datasets. ChromActivity generates genomewide predictions of regulatory activity associated with …
Read PDFHepatocellular carcinoma (HCC) remains a significant global health challenge, with therapeutic efficacy in advanced stages often limited by underlying liver dysfunction and adaptive resistance. In this review, the evolving landscape of molecular targets and combinatorial …
Read PDFCancer treatment is an ongoing challenge, as directly targeting oncogenic drivers is often unfeasible in many patients due to the lack of druggable targets. This has led to the exploration of alternative strategies, such as …
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Read PDFRett syndrome (RTT) is a severe neurodevelopmental disorder primarily affecting females, caused by mutations in the X-linked gene <i>MECP2</i>. This gene encodes methyl CpG binding protein 2 (MeCP2), a multifunctional epigenetic regulator critical for neuronal …
Read PDFHeart failure (HF) is a complex and heterogeneous clinical syndrome defined by progressive structural, functional, and molecular alterations in the myocardium, representing a significant global health challenge. Beyond haemodynamic compromise, HF arises from intricate interactions …
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