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BACKGROUND: Accumulating evidence indicates that N6-methyladenosine (m6A) modification of circular RNAs (circRNAs) plays a pivotal role in regulating cancer progression. However, in head and neck squamous cell carcinoma (HNSCC), the biological functions and underlying mechanisms …
Read PDF<h4>Introduction</h4>The airway epithelial barrier continues to develop during the first year of life, representing a critical time window of susceptibility to the effects of respiratory viruses that may contribute to the development of childhood asthma. …
Read PDFDNA methylation modifies nucleotides, regulating gene expression without sequence change. The effects of DNA methylation within blood cell lineages on the development and function of endomitotic high DNA copy megakaryocytes (MKs) to anucleate platelets remain …
Read PDFThe integration of environmental cues into cellular programs is crucial for cell function. Yet, how this integration is modulated due to cellular aging remains unclear. We propose that the 3D chromatin organization filters these signals …
Read PDFNF-κB signaling can be subdivided into canonical and noncanonical pathways, culminating in the transcriptional activity of RELA and RELB, respectively. However, the upstream signals that activate these transcription factors and their specific regulatory roles in …
Read PDFChanges in DNA methylation and gene expression play a major role in the epileptogenic process that turns a healthy brain into an epileptic brain. Previous investigations have focused either on changes in the transcriptome or …
Read PDFAdult women are typically exposed to 17β-estradiol (E2) concentrations of ~100 to 200 pM, yet most cell-based studies use 100 nM. We determined the molecular effects of E2 concentrations spanning six orders of magnitude (1 …
Read PDFTumor cell plasticity drives metastasis and therapy resistance, yet its regulation by oncoprotein dosage dynamics remains poorly understood. In Ewing sarcoma (EwS), variations in EWS::FLI1 (EF) fusion oncoprotein activity have been associated with epithelial-mesenchymal plasticity …
Read PDFVascular smooth muscle cells contribute to heritable coronary artery disease risk and undergo complex transitions to multiple disease-related phenotypes. To investigate the genetic basis of these trajectories, we develop a dense timecourse single-cell transcriptomic and …
Read PDFHigh mobility group AT-hook 1 (HMGA1) is a chromatin regulator overexpressed in various cancers, often predicting poor outcomes. However, its role in head and neck squamous cell carcinoma (HNSCC) remains unclear. A hallmark of HNSCC …
Read PDFPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of human malignancy, and there is an urgency to develop more effective therapy. We previously showed that Metavert, a dual inhibitor of glycogen synthase kinase …
Read PDFR-loops, three-stranded nucleic acid structures formed by an RNA-DNA hybrid, have emerged as important regulators of transcription and genome stability. Although advances in high-throughput sequencing have revealed widespread R-loop landscapes, platform-specific biases hinder the identification …
Read PDFThree bacterial strains, 1AS11<sup>T</sup>, 1AS12 and 1AS13, members of the new symbiovar salignae and isolated from root nodules of <i>Acacia saligna</i> grown in Tunisia, were characterized using a polyphasic approach. All three strains were assigned …
Read PDFThe efficient enzymatic conversion of lignocellulose into fermentable sugars is essential for producing sustainable biofuels and biochemicals. During a screening for lignocellulose-degrading microorganisms, a novel bacterial strain, designated KULCS107T, was isolated from soil associated with …
Read PDFThe genus <i>Tuber</i> (family: Tuberaceae) includes the most economically valuable ectomycorrhizal (ECM), truffle-forming fungi. Previous genomic analyses revealed that massive transposable element (TE) proliferation represents a convergent genomic feature of ECM fungi, including Tuberaceae. Repetitive …
Read PDFA novel moderately halophilic and alkaliphilic Gram-stain-negative, strictly aerobic, bacterial strain (N2<sup>T</sup>) was isolated from an inland saltern in central Portugal. The taxonomic position of this isolate was determined based on polyphasic taxonomic and phylogenomic …
Read PDFPutative metazoan body fossils from the Precambrian are curiously lacking morphological characteristics that link them unambiguously to extant animal phyla, including sponges. Chemical fossils such as the rare C<sub>30</sub> hydrocarbons 24-<i>iso</i>-propylcholestane (24-<i>i</i>pc) and 26-methylstigmastane (26-mes), …
Read PDF<i>Bactrocera dorsalis</i> (Hendel) is a major fruit-feeding pest that poses a severe and persistent threat to the horticulture industry in tropical and subtropical regions. Methyl eugenol (ME) is a powerful male-specific attractant phytochemical and pheromone …
Read PDFThe Asian longhorned beetle, Anoplophora glabripennis (Motschulsky), and the citrus longhorned beetle, A. malasiaca (Thomson) (Coleoptera: Cerambycidae), represent two globally notorious forest pests whose introductions into North America and Europe have caused extensive damage to …
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