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Colorectal cancer (CRC) is a biologically heterogeneous disease in which single-omics analyses incompletely capture the cross-layer mechanisms underlying tumor progression, immune evasion, and therapeutic resistance. This review critically examines how the integration of genomics, transcriptomics, …
Read PDF<h4>Background</h4>Osteoporosis is a complex disorder involving bone loss and muscle degeneration. Multi-omics technologies provide novel insights into its molecular mechanisms and may support biomarker discovery, patient stratification, and therapeutic development.<h4>Objective</h4>This scoping review aimed to synthesize …
Read PDFStroke survivors face an elevated risk of developing Alzheimer's disease (AD), yet the biological mechanisms linking these conditions remain poorly defined. Here, we show that a stroke-induced gut microbiome is a key driver of AD-related …
Read PDFControlled plant growth in laboratories can be achieved by cultivating plants under sterile or axenic conditions on predefined synthetic growth media, typically supplemented with sugar. In nature, plants do not receive exogenous sugar supplies, form …
Read PDFCultural heritage sites are commonly exposed to outdoor environments, resulting in severe damage to heritage objects from biotic and abiotic processes. Control of outdoor environments is impossible for heritage conservation, and we cannot prevent the …
Read PDFMicrobial predators obtain energy from killing other living cells. <i>Streptomyces</i> are soil bacteria that are known to produce numerous catabolic enzymes and antimicrobial compounds to defend against competing organisms. Here, we demonstrate that <i>Streptomyces</i> are …
Read PDF<h4>Background</h4>Multiple Sclerosis is a chronic autoimmune disease that attacks the myelin sheath in the central nervous system, with a higher prevalence among female patients. We and others have documented significant changes in microbial taxa in …
Read PDFThe global prevalence of gastrointestinal tumours and the bottlenecks in their diagnosis and treatment are being systematically overcome by the multi-omics revolution: high-throughput technologies are driving the multidimensional integration of genomics-transcriptomics-proteomics-metabolomics to comprehensively decode the …
Read PDFThis review advocates for the formal recognition of Type 5 Diabetes Mellitus, a distinct, neglected form of non-autoimmune, lean diabetes predominantly affecting low-income and middle-income populations with a history of early-life malnutrition. Characterized by impaired …
Read PDFHidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder of the pilosebaceous unit, with multiple factors contributing to its onset, activity and progression. Alongside a predisposing genetic background, hormonal and microbiome alterations, dysregulation of innate …
Read PDFWe read the paper published in <i>World Journal of Gastroenterology</i> by Yang <i>et al</i> on how <i>Bifidobacterium</i> species alleviate colitis by modulating deoxycholic acid (DCA) levels and macrophage polarization, which provides important insights into the …
Read PDFMany helminths and protozoa are transmitted to humans through the consumption of contaminated food or water, and this underlines the importance of methods for their detection in these matrices. Due to the difficulties in isolating …
Read PDFCassava brown streak disease (CBSD), caused by cassava brown streak virus (CBSV; <i>Ipomovirus brunusmanihotis</i>) and Ugandan cassava brown streak virus (UCBSV; <i>Ipomovirus manihotis</i>) (family <i>Potyviridae</i>, genus <i>Ipomovirus</i>), is increasingly becoming a threat to cassava production …
Read PDFIn order to understand the dynamic interaction process among species, enzymes, and metabolites during the fermentation process of Baobaoqu, which is a representative Daqu starter for Chinese baijiu, the intimate connection between the progression of …
Read PDF<h4>Background</h4>The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) registry shows considerable variation in culturable microbes in sputum between different European countries. The additive role of next-generation metagenomic sequencing remains unexplored and the association with …
Read PDFThe relationship between frailty and gut microbiota has not been previously addressed in patients with cirrhosis. We studied by metagenomic shotgun sequencing the faecal microbiota composition associated with frailty in 29 patients with cirrhosis from …
Read PDFDuring the past two decades, much work has characterized the composition and function of the gut microbiome on diverse wildlife in the framework of conservation metagenomics. While promising for conservation, translating theory into practice remains …
Read PDFAdvances in deforestation and climate change directly cause changes in habits and the distribution of Culicidae across the globe, especially mosquitoes of medical importance and the main vectors of arboviruses. The viral metagenomics technique can …
Read PDFMushrooms offer a promising solution for sustainable food production due to their nutritional value, low resource requirements, and ability to grow in diverse environments. As interest in mushrooms grows, it is important to understand where …
Read PDF<i>Ochetobibus elongatus</i> (Kner) is a migratory fish found in the Yangtze River basin and areas south of it, and listed as a critically endangered (CR) fish on the China Red List of Vertebrates. To achieve …
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