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1201 results

Full text 2025

A new species of <i>Purpureocillium (Ophiocordycipitaceae)</i> fungus parasitizing trapdoor spiders in Brazil's Atlantic Forest and its associated microbiome revealed through <i>in situ</i> "taxogenomics"

Araújo JPM, Przelomska NAS, Smith RJ, et al.

Our planet is inhabited by an estimated 2.5 million species of fungi, of which fewer than 10% have been scientifically described. Some of the most understudied yet remarkable fungal species are those capable of parasitizing …

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Metagenomics
Full text 2026

Improving the Precision of Etiological Diagnosis in Bacterial Infections Using Molecular Technologies: A Comparative Analysis of Platforms, AI Integration, and Point-of-Care Deployment

Cotelici AM, Bălășoiu AT, Boldeanu MV, et al.

Bacterial infections remain a major global health burden, further exacerbated by the rapid emergence of antimicrobial resistance (AMR), which increases the need for accurate and timely etiological diagnosis. Conventional culture-based methods are limited by prolonged …

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Metagenomics
Full text 2025

Decoding microbiome responses to quarantine potato wart disease: first insights into suppression and biocontrol by full-length 16S rRNA gene profiling and functional prediction

Akbar I, Shi Y, van de Vossenberg BTLH, et al.

<h4>Introduction</h4><i>Synchytrium endobioticum</i>, the biotrophic pathogen causing potato wart, poses persistent challenges due to its long-term soil survival and quarantine status. Biological control agents (BCAs) offer a promising avenue for sustainable management, yet the ecological context …

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Metagenomics
Full text 2026

Metagenomic analysis of the human gut virome reveals functional signatures and viral stability across hospitalized and non-hospitalized diarrheal and non-diarrheal individuals

Ramírez AL, Páez L, Vega L, et al.

<h4>Background</h4>The human gut virome is a fundamental yet understudied component of the intestinal microbiome. However, its taxonomic composition and functional potential in Latin American populations remain poorly understood, particularly under clinical stressors such as hospitalization …

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Metagenomics
Full text 2025

An NGS-assisted diagnostic workflow for culture-independent detection of bloodstream pathogens and prediction of antimicrobial resistances in sepsis

Pinzauti D, Biazzo M, Podrini C, et al.

<h4>Background</h4>Timely and accurate identification of bloodstream pathogens is critical for targeted antimicrobial therapy in sepsis. Conventional blood cultures remain the Standard-of-Care (SoC) for pathogen identification but are limited by low sensitivity and prolonged turnaround times, …

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Metagenomics
Full text 2026

Pathogen spectrum identified by targeted nanopore sequencing and exploratory analysis of hematological biomarkers in suspected intracranial infections

He Z, Zhihong H, Shuijin L, et al.

<h4>Background</h4>Intracranial infections are severe, life-threatening conditions often caused by diverse pathogens. Targeted nanopore sequencing (TNPseq) offers rapid and accurate pathogen identification, addressing the limitations of traditional diagnostic methods. Besides the pathogen types, factors like inflammation …

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Metagenomics Nanopore Sequencing
Full text 2025

Pike: OTU-Level Analysis for Oxford Nanopore Amplicon Metagenomics

Krivonos DV, Fedorov DE, Konanov DN, et al.

The Oxford Nanopore platform and nanopore sequencing are gaining increasing popularity in modern metagenomic research. However, there is a limited set of dedicated tools for analyzing this type of data. The tools used for nanopore …

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Metagenomics Nanopore Sequencing
Full text 2026

&lt;i&gt;Dokdonella aquatica&lt;/i&gt; sp. nov., isolated from freshwater

Lee JK, Lim CW, Moon CY, et al.

A Gram-stain-negative, strictly aerobic, non-motile, non-flagellated and rod-shaped bacterium, strain MW10<sup>T</sup>, was isolated from freshwater in South Korea. The strain exhibited catalase-negative and oxidase-positive activities and grew at 15-35 °C (optimum, 25 °C), pH 6.0-9.0 …

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Epigenetics Metagenomics
Full text 2026

Gut microbiota and its association with gastrointestinal symptoms and pharmacological treatments in a sibling-matched cohort with autism spectrum disorder

Peñalba F, Guisande A, Lamberti L, et al.

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder marked by difficulties in communication, social interaction, and restricted, repetitive behaviors. The gut microbiota has emerged as a key factor in the gut-brain axis relevant to …

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Metagenomics Nanopore Sequencing
Full text 2026

A cross-sectional metagenomic analysis of the microbial ecology in symptomatic apical periodontitis - An &lt;i&gt;in vivo&lt;/i&gt; study

Shaji A, Ramachandran AK, Chandrasekaran N, et al.

<h4>Background</h4>Symptomatic apical periodontitis (SAP) is a painful inflammatory disease driven by root canal infection. A detailed understanding of its microbial ecology, compared to a noninfectious baseline, is needed.<h4>Aims</h4>This study aimed to characterize the microbial ecology …

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Metagenomics