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Relational databases offer an efficient solution for storing and retrieving complex data sets, yet the requirement for SQL programming expertise presents a significant challenge for many life science users. We explore whether a cutting-edge large …
Read PDFIdiopathic normal pressure hydrocephalus (iNPH), a leading cause of reversible dementia in older adults, is marked by ventriculomegaly, gait disturbances, cognitive decline, and urinary incontinence. Emerging evidence suggests that gut dysbiosis (microbial imbalance) may influence …
Read PDFThe human gut microbiome plays a crucial role in human health, adapting and responding to changes in diet, environment, and lifestyle. However, current microbiome research is heavily biased toward high-income countries, leaving regions such as …
Read PDFThe river Yamuna is one of the most polluted rivers in India and is heavily impacted by urban, industrial, and agricultural inputs. In this study, shotgun metagenomics was used to investigate microbial diversity and functional …
Read PDF<h4>Background</h4>The Baltic Sea receives petroleum hydrocarbons from various point sources. The degradation of these contaminants in the environment is typically facilitated by a variety of microorganisms that possess a range of genes and metabolic functions …
Read PDF<h4>Background</h4>To describe both host gene expression and microbiome composition in a single sample, parallel experimental and computational workflows (mRNA-sequencing and either 16S rRNA gene or metagenomics) have been traditionally applied. The vulvar milieu represents an …
Read PDFBiohacking, the self-directed application of biotechnology, digital tools, and lifestyle interventions, has rapidly converged with gut microbiome science to create adaptive, individualized, and minimally invasive precision-health paradigms. This narrative review integrates current evidence on diet-based …
Read PDFDeposition of three key 4-alkyl branched-chain fatty acids (<b>KBCFA</b>), including 4-methyloctanoic acid (<b>MOA</b>), 4-ethyloctanoic acid (<b>EOA</b>), and 4-methylnonanoic acid (<b>MNA</b>), causes the gamey flavor in sheep meat. This study integrated metagenomics and metabolomics to evaluate …
Read PDFSpontaneous fermentation of Sichuan paocai is shaped by complex microbial and environmental factors, yet phage communities remain understudied. This study presents integrated viromic and metagenomic analysis of radish paocai combined with metabolite profiling to elucidate …
Read PDFAntibiotic resistance is a significant threat to global public health and can disproportionately affect low- and middle- income countries (LMICs). There is a lack of studies focusing on antibiotic resistance in coral reef regions and …
Read PDF<h4>Rationale</h4>Lawsonella clevelandensis is a gram-positive bacterium, partially acid-fast, strictly anaerobic, nonspore-forming, and catalase-positive. This microorganism was once overlooked in clinical microbiology due to its stringent growth requirements in laboratory cultures, but it has recently attracted …
Read PDFIn regions where both monkeypox virus (MPXV) and varicella zoster virus (VZV) are co-circulating, overlapping clinical manifestations can complicate clinical diagnosis. During the MPXV outbreak declared in Uganda in July, 2024, symptomatic suspected cases tested …
Read PDFViruses are key regulators of marine microbial communities, yet their temporal dynamics in tropical intertidal sediments remain poorly characterized. We conducted a year-long metagenomic survey of sandy intertidal sediments in Sanya Bay (60 monthly samples …
Read PDF<h4>Aim</h4>To characterize the impact of periodontitis and of Steps I-II of periodontal therapy on microbiome composition, function, and metabolic output across the oral and gut environments.<h4>Methods</h4>A multi-omics analysis was performed on saliva and stool samples …
Read PDF<h4>Introduction</h4>With the rapid development of 16S rRNA sequencing and metagenomic technologies, the traditional concept of sterile urine has been completely overturned, and a diverse urinary microbiome has been identified even in healthy individuals. Increasing evidence …
Read PDFThe Nebraska Salt Marshes are unique inland saltwater ecosystems, and this exploratory study is aimed at understanding the microbial composition and diversity that is providing the underlying support for these ecosystems. The microbiome shows both …
Read PDFSoils are vibrant and diverse natural entities situated at the juncture between Earth, air, water, and life [...].
Read PDFMetagenomic Hi-C (metaHi-C) links mobile genetic elements to their cellular hosts directly within complex microbial communities. Once shotgun and Hi-C libraries have been generated, however, the main challenges shift to the bioinformatics required for preprocessing, …
Read PDF<h4>Objective</h4>While gut microbiota (GM) dysbiosis has been implicated in hypertension, the sexassociated microbial signatures and their underlying mechanisms remain poorly understood, particularly in populations living in unique geographical and climatic conditions.<h4>Design</h4>Through an integrated approach combining …
Read PDFEnzymes, as key biocatalysts, are essential for advancing sustainable green technologies across diverse industrial sectors. The discovery of novel enzymes is essential for expanding their applications. In this study, we identified new lipases using an …
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