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Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized clinically by a constellation of motoric deficits including resting tremors, bradykinesia, and rigidity. In recent years, there has been increasing interest in the gut-brain …
Read PDF<h4>Objective</h4>To systematically evaluate the clinical efficacy of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) on glycemic control in adults with type 2 diabetes (T2D) and related dysglycemia, and to synthesize associated mechanistic changes in …
Read PDFUnderstanding how microbial communities respond to disturbance remains a fundamental question in ecology, with broad implications for biodiversity, ecosystem function, and biotechnology. Trait-based approaches offer general rules to predict community responses by linking ecological strategies …
Read PDFDuring preparedness activities in Senegal to the 2024 Mpox Public Health Emergency of International Concern, a study was conducted to assess the prevalence of Varicella-Zoster virus among patients suspected of having Mpox. Samples, including skin …
Read PDFMetagenomic analyses of microbial communities have unveiled a substantial level of interspecies and intraspecies genetic diversity by reconstructing metagenome-assembled genomes (MAGs). The MAG database (MAGdb) boasts an impressive collection of 74 representative research papers, spanning …
Read PDFThe human microbiome is increasingly recognized as a key determinant of health and disease, yet methodological variability continues to limit reproducibility and clinical translation of findings. This review synthesizes current approaches in microbiome research, critically …
Read PDFBats are highly diverse mammals and known reservoirs of numerous zoonotic viruses. Their role in the ecology of emerging infectious diseases continues to be of significant interest. This study aimed to evaluate the occurrence of …
Read PDFShotgun metagenomics holds great potential for identifying parasite DNA in biological samples, but its effectiveness is limited by widespread contamination in publicly available reference genomes, which hinders accurate detection. In this study, we systematically quantify …
Read PDFAccurately predicting coding genes from metagenomic samples containing a high proportion of eukaryotic content remains a significant challenge. Novel and reliable methods for the simultaneous prediction of prokaryotic and eukaryotic microbial genes are crucial to …
Read PDFUrban wetlands are assumed to contribute to nitrous oxide (N<sub>2</sub>O) emissions; however, the microbial mechanisms underlying enhanced N<sub>2</sub>O fluxes in urban wetlands and differences in microbial responses between aquatic and soil compartments have not been …
Read PDF<h4>Background</h4>For the first time, a case of vertical transmission of TBEV in a dog associated with foetal death is described.<h4>Case presentation</h4>A six-year-old beagle bitch experienced foetal death from day 49 in pregnancy. A caesarean section …
Read PDFBACKGROUND: Next generation sequencing (NGS) has expanded virus detection capabilities beyond the limitations of sequence-specific methods. While mosquito collections in South Africa (SA) have been investigated for the major arbovirus genera (Alpha-, Orthobunya-, and Orthoflavivirus), …
Read PDFCable bacteria conduct long-distance electron transport in sediments but are not yet isolated in pure culture. We report the metagenome-assembled genome of <i>Candidatus</i> Electrothrix sp. NPCB-01 from Newport Bay, California. This 3.46-Mb genome encodes sulfur …
Read PDFRed raspberries have been shown to exert beneficial effects on immunometabolic health in numerous studies; however, these effects are subject to interindividual variability. Building on a previous transcriptomic-based clustering analysis from an 8-week randomized controlled …
Read PDFProbiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. One of the most common uses of probiotics is for prevention of antibiotic-associated diarrhea (AAD). Here we report …
Read PDFInflammatory bowel disease (IBD) involves chronic intestinal inflammation driven by gut-brain axis imbalance, fostering complications through an "inflammation-neuro-coagulation" triad. Current staging systems inadequately capture the dynamics of this multidimensional network. Therefore, integrated multi-omics analyses-including metagenomics, …
Read PDFThe analysis of high-dimensional microbiome multiomics datasets is crucial for understanding the complex interactions between microbial communities and host physiological states across health and disease conditions. Despite their importance, current methods, such as the microbe-metabolite …
Read PDFMicroorganisms are key players in the global cycling of nitrogen and carbon, controlling their availability and fluxes, including the emissions of the powerful greenhouse gases nitrous oxide and methane. Standard sequencing methods often reveal only …
Read PDF<h4>Background</h4>House dust mite (HDM) sensitization is a leading cause of allergic rhinitis and asthma worldwide, with <i>Dermatophagoides pteronyssinus</i>, <i>Dermatophagoides farinae</i>, and <i>Blomia tropicalis</i> being the primary allergenic species typically associated with indoor environments. Even effective …
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