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Macrophages are pivotal immune cells due to their phagocytic capabilities, yet the impact of aging on macrophage phagocytosis remains poorly understood. Using comprehensive in vitro and in vivo phagocytic assays, we demonstrate significantly reduced phagocytic …
Read PDFBronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and is characterized by aberrant late-stage lung development driven by multiple factors. Although previous studies have demonstrated that BPD is associated with …
Read PDFProstate cancer (PCa) is a major health problem worldwide with variable incidence, progression and outcomes depending on genetic, environmental and socio-economic factors. This study compares gene expression profiles in PCa patients from South Africa (RSA) …
Read PDFRegulation of gene expression at the transcriptional and post-transcriptional levels is essential for proper development and growth, with tightly coordinated cellular processes supporting key biological functions. While transcription determines the available mRNA pool, post-transcriptional modifications …
Read PDFDiatoms are abundant unicellular microalgae that play a fundamental role in global aquatic ecosystems, producing bioactive secondary metabolites with different functions, from signalling to defence. They exhibit complex life cycles comprising distinct phases: active growth, …
Read PDFMultinucleation in cancer has been shown to promote aneuploidy, which correlates with tumor aggressiveness. This is particularly true for melanoma, a cancer caused by excessive proliferation of melanocytes, whose RAS/ERK pathway is overactivated. Using single-nucleus …
Read PDF<h4>Summary</h4>EnrichmentMap: RNASeq (enrichmentmap.org) is an intuitive, web-based app for gene-set enrichment analysis and visualization, specifically supporting two-case RNA-Seq experiments for Homo sapiens. The web app introduces a simplified user interface, faster processing times, and eliminates …
Read PDF<h4>Objective</h4>To determine whether baseline epigenomic and transcriptional profiles of human dental pulp stem cells (DPSCs) differ by sex, and to assess sex dependence of key markers related to growth and stemness.<h4>Methods</h4>Primary DPSCs from nine young …
Read PDF<h4>Background</h4>Musculoskeletal injuries comprise a growing source of disability worldwide, and the recovery of muscle strength following injury is a critical determinant of patient reported outcomes. Females experience exacerbated muscle atrophy, poorer outcomes, and higher re-injury …
Read PDF<h4>Background</h4>Medulloblastoma and ependymoma are common pediatric central nervous system tumors with significant molecular and clinical heterogeneity. While molecular subgrouping has enabled classification into molecular subtypes, the extent of heterogeneity within these subgroups remains poorly defined.<h4>Methods</h4>We …
Read PDFSmall cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid progression, early metastasis, and high relapse rates due to acquired chemoresistance. The human DEAD-box RNA helicase DDX5 is overexpressed in SCLC and has …
Read PDF<h4>Background</h4>Myeloproliferative neoplasms (MPN) comprise a heterogenous group of hematological malignancies that include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Current therapeutic strategies rely on cytoreductive approaches that mitigate disease burden and thromboembolic …
Read PDF<h4>Background</h4>In humans, <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> species complexes are the leading cause of fungal meningitis globally. To establish CNS infection, <i>Cryptococcus</i> must breach the BBB, primarily comprised of specialized brain microvascular endothelial cells (BMECs), …
Read PDFDespite the widespread use of progesterone or progesterone receptor (PGR) blockers as contraceptives, the complete set of PGR-regulated genes and their roles in human ovulatory follicles remain unidentified. Here, we identified the PGR-regulated transcriptome, revealing …
Read PDFAging is a dominant risk factor for chronic diseases characterized by the functional decline of tissues and organs. During aging, the hematopoietic system declines in regenerative capacity-seemingly attributable to increases in DNA damage, replicative stress, …
Read PDFDuring zebrafish embryonic body elongation, differentiation of mesodermal progenitors into presomitic mesoderm requires the transcription factors tbx16 and mesogenin 1. Here, by using temporally controlled tbx16 and mesogenin 1 overexpression and RNAseq to identify immediate …
Read PDFAlzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by the simultaneous disruption of interconnected molecular pathways, yet the structural mechanisms underlying this transcriptional disintegration remain poorly characterized. To address this, we constructed condition-specific gene …
Read PDFType I interferons (IFNs) play crucial roles in antiviral defence, autoinflammation and cancer immunity. The human genome encodes 17 different type I IFNs that all signal through the same receptor. Non-redundant functions have been reported …
Read PDFGene up(down)regulation findings in single-cell and spatial RNA sequencing can be inconsistent despite remarkable progress in technology. Inconsistent findings in high-quality samples raise concerns about assumptions behind widely accepted data analysis approaches. We, therefore, propose …
Read PDFEpstein-Barr virus (EBV) latent infection is causally linked to several epithelial cancers, including endemic forms of undifferentiated nasopharyngeal carcinoma (NPC), and to a subtype of gastric cancer (GC). EBNA1 is the virus-encoded sequence-specific DNA-binding protein …
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