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<h4>Background</h4>Genomic imprinting, a mechanism resulting in parent-of-origin expression of genes through epigenetic regulation, intersects with a broad range of biological fields, including evolution, molecular genetics and epigenetics, and determinism of complex traits. Although next generation …
Read PDFHepatic stellate cells (HSC) are known for their major role in hepatic fibrosis. It is well established that upon liver injury, they undergo a transition from a quiescent state to an activated state and transdifferentiate …
Read PDFSARS-CoV-2 infection disrupts iron homeostasis in organs such as the lung. Emerging evidence suggests similar dysregulation in the placenta may impair function and fetal growth. Ferroptosis, an iron-dependent form of cell death, is driven by …
Read PDFHexanucleotide repeat expansions in <i>C9orf72</i> are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD); yet, mechanisms underlying selective neuronal vulnerability remain unclear. A major challenge in identifying consistent transcriptomic …
Read PDF<h4>Objective</h4>To investigate the effects of a matrikine, fibronectin fragment (FN7-10), on human osteoarthritic (OA) synovial fibroblasts and implications for inflammation and cartilage degradation.<h4>Design</h4>Joint tissue was obtained from 50 OA patients undergoing knee arthroplasty. Isolated synovial …
Read PDFSuicide remains a critical global public health issue, accounting for nearly one million deaths annually and imposing profound societal and economic burdens. Despite its urgency, the lack of diagnostic and predictive biomarkers continues to hinder …
Read PDFChitinase-3-like protein 1 (CHI3L1) is a secreted, non-enzymatic glycoprotein that interacts with cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides. Many studies reported the overexpression of CHI3L1 in various cancers, but its exact role in tumorigenesis/cancer …
Read PDFColorectal cancer (CRC) is a major health concern and understanding its molecular characteristics is crucial for improving its diagnosis and treatment. Here, we present a comprehensive analysis utilizing RNA-sequencing (RNA-seq) data and clinical information from …
Read PDFThe development of the central nervous system is regulated by multiple spatio-temporally varying factors that are essential for neurons to form functional networks. Prenatal ultrasound (US) exposure may affect the dendritic arborization and spine density …
Read PDFCellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance on reference data selection and integration. …
Read PDFPneumonia is the leading infectious disease killer worldwide and commonly requires admission to critical care. Despite its prevalence, the underpinning biology of severe pneumonia remains incompletely understood. Here we perform multifaceted assessments of bronchoalveolar transcriptome, …
Read PDFAlcohol use disorder (AUD) is one of the most prevalent mental health disorders worldwide yet effective therapeutics remain limited. Mounting evidence indicates that dysregulated immune signaling in the brain plays a role in AUD pathophysiology. …
Read PDFPhenotypic variation is detrimental for deciphering the genetic control of valuable traits in crop plants. Safflower (Carthamus tinctorius L.) is an industrial and medicinal plant with natural stress-resilience. In this study, we used two bulk …
Read PDFVitamin D is a crucial micronutrient for vertebrate health that affects musculoskeletal function and likely modulates immune responses in tissues such as the skin. Infectious diseases are a critical concern in Atlantic salmon aquaculture due …
Read PDFTherapies promoting microvascular flow and endothelial repair require effective identification of new targets in ischemic heart disease (IHD). The aim of this study was to unravel and functionally investigate circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) …
Read PDFSmall Cell Carcinoma of the Ovary (SCCO) is an extremely rare form of ovarian cancer characterised by bi-allelic mutations in the <i>SMARCA4</i> gene, a member of the SWI/SNF chromatin remodelling complex. Most previous analyses have …
Read PDF<h4>Background</h4>Combining high-dose stereotactic body radiation therapy (SBRT) with FOLFIRINOX (FFX) is promising as neoadjuvant strategy for pancreatic ductal adenocarcinoma (PDAC). This study provides an in-depth histo-molecular characterisation of resected PDAC samples from patients treated with …
Read PDF<i>Background</i>-Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies, with a dismal 5-year survival rate. Despite continuous efforts to study its molecular signatures, the high degree of tumor-associated cellular heterogeneity in PDAC introduces extraneous microenvironmental …
Read PDF<i>Helicobacter pylori</i> infection is the main risk factor for gastric cancer. <i>H. pylori</i> easily develop antibiotic resistance and evade host defenses. In-depth knowledge of the first barrier that <i>H. pylori</i> encounter, the gastric surface mucus-producing …
Read PDFBACKGROUND: Deep vein thrombosis (DVT) is a common clinical problem characterized by the formation of blood clots in deep veins. The contribution of venous smooth muscle cells (SMCs) to the onset of DVT, particularly the …
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