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<h4>Introduction</h4>Hutchinson-Gilford Progeria Syndrome (HGPS) is a fatal, accelerated-aging disease caused by a mutation in the nuclear envelope protein Lamin A. The resulting mutant protein, progerin, accumulates on the nuclear envelope, causing nuclear blebbing, altered gene …
Read PDFAging is associated with increased susceptibility to metabolic stress and chronic liver disease, yet the interactions between age and metabolic stressors and the potential for ameliorating interventions remain incompletely understood. Here, we examined the hepatic …
Read PDFThe NeoPAL trial compares neoadjuvant letrozole-palbociclib (LP) with chemotherapy (CT) in 103 patients with high-risk, early luminal breast cancer. At surgery, the NanoString BC360 proliferation score and Ki67 expression are reduced in both arms, together …
Read PDFPreeclampsia is a severe gestational complication whose molecular pathogenesis remains poorly understood despite extensive research. It is now recognized that both maternal and fetal cells contribute to disease progression. Notably, single-cell RNA sequencing of cord …
Read PDFThe Turpan minnow (Phoxinus grumi) is a small endemic fish species inhabiting the extreme environment of the Turpan Basin in Xinjiang, China, holding significant value for evolutionary and conservation biology research. However, the absence of …
Read PDFThe Muscovy duck (Cairina moschata) is an excellent lean-type poultry species characterized by large body weight, rapid growth, high lean meat yield, good liver production performance, and high feed conversion efficiency. It plays an important …
Read PDF<h4>Objectives</h4>Through a genomics-based approach analyzing gene expression levels and adaptive immune receptor recombinations, we sought to determine whether MYC amplification was associated with a worse outcome and reduced immunogenicity.<h4>Methods</h4>MYC copy numbers and the presence of …
Read PDFCXCL14 is a highly conserved chemokine with potential roles in tumor progression and immune modulation. This study investigates the functional impact of CXCL14 on colon cancer by exploring its effects on tumor cell behavior and …
Read PDFEarly mammalian embryos are highly sensitive to environmental, metabolic, hormonal, and genomic stress, yet embryo assessment during <b>I</b>n <b>V</b>itro <b>F</b>ertilization (<b>IVF)</b> relies largely on morphology and ploidy for embryo assessment, but these tests incompletely predict …
Read PDFChromatin remodelers play essential roles in modulating nucleosome structure and enabling dynamic transcriptional control. Arabidopsis calmodulin-binding transcription activators CAMTA1/2/3 negatively regulate plant immunity by suppressing the expression of biosynthesis genes of major defence hormones salicylic …
Read PDF<h4>Introduction</h4><i>Mycobacterium avium</i> subs. <i>hominissuis</i> is an opportunistic pathogen, causing pulmonary infections in individuals who are immunocompromised or whose respiratory systems are damaged due to injuries or diseases such as cystic fibrosis, bronchiectasis, or chronic obstructive …
Read PDFHIF-prolyl hydroxylase inhibitors are used to treat anemia in chronic kidney disease. These drugs stabilize hypoxia-inducible factors HIF-1α and HIF-2α, which activate erythropoiesis and iron metabolism pathways. Clinically approved HIF-PHIs including roxadustat and molidustat exhibit …
Read PDFSleep fragmentation is common in older adults and is associated with cognitive impairment and dementia, as well as key histopathological correlates of dementia, including small vessel disease and cerebral infarcts. Vascular and blood-brain barrier dysfunction …
Read PDFPeripheral sensory neurons are a primary effector in pain neurotransmission, and have become a useful cellular model for the study of pain. While rodent tissue has historically served as a source of these neurons, it …
Read PDFCells release heterogeneous extracellular vesicles and particles (EVPs) into circulation, carrying RNA and proteins that reflect their origin. Recently, brain-derived EVs have gained significant attention as non-invasive biomarkers for Alzheimer's disease (AD). Here, we identified …
Read PDFObesity and related metabolic disorders are often characterized by chronic adipose tissue inflammation, driving systemic insulin resistance and general metabolic dysfunction. Free Fatty Acid Receptor 2 (FFA2) has emerged as a potential modulator of adipocyte …
Read PDFThe innate immune signaling pathway cGAS-STING plays an important role in the recognition of cytosolic nucleic acids and the induction of the interferon-dependent antiviral response. Despite the significant research interest in this cascade in the …
Read PDFRett syndrome arises from loss-of-function mutations in the X-linked chromatin regulator MECP2, yet the earliest molecular derailments in development are poorly defined. Using isogenic human embryonic stem cell (hESC) models carrying three patient-derived MECP2 mutations, …
Read PDFThe development of the zoonotic parasitic tapeworm Taenia solium from larval to adult involves significant but often clinically overlooked events crucial in cestode biology. The early-adult events can be studied in vitro, providing a valuable …
Read PDF<h4>Background</h4>The current biomarker framework for the diagnosis and staging of Alzheimer's disease (AD) relies mainly on neuropathological features; thus, its performance for diagnosis is limited prior to the initiation of neurodegeneration. Here, we leveraged transcriptomic …
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