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<h4>Background</h4>Colorectal cancer with microsatellite stable (MSS) status is intrinsically resistant to immune checkpoint inhibitor monotherapy targeting PD-1 or PD-L1. However, emerging evidence suggests that chemotherapies may overcome this resistance when combined with immunotherapy.<h4>Methods</h4>We conducted a …
Read PDFPapillary thyroid carcinoma (PTC) is a malignancy with an ambiguous etiology. The competitive endogenous RNA (ceRNA) hypothesis provides a framework for clarifying the molecular mechanisms that drive carcinogenesis. In this study, we constructed a novel …
Read PDFBrain aging consists of a progressive loss of functional capacities, which is associated with a progressive cognitive decline and can lead to neurodegenerative diseases. Studies comparing the underlying molecular mechanisms of the human hippocampus between …
Read PDFDesert animals have evolved systems that enable them to thrive under dry conditions. A plethora of adaptations are well studied and, more recently, the molecular underlying mechanisms have been investigated, but these are not fully …
Read PDFImmune checkpoint inhibitors (ICIs) transform cancer therapy, but their efficacy in hepatocellular carcinoma (HCC) remains limited due to tumor-intrinsic immune evasion. We investigate the epigenetic regulator G9a (EHMT2) as a driver of immune resistance and …
Read PDF<h4>Background</h4>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive decline and memory impairment. This condition imposes a considerable economic burden on healthcare systems worldwide.<h4>Objective</h4>Current diagnostic approaches often lack specificity and sensitivity, necessitating …
Read PDFOrofacial clefting (OFC) is among the most common birth defects and can occur either as part of a syndrome or in isolation (nonsyndromic, ns). Cleft palate only (CPO) is an OFC subtype. Here, we searched …
Read PDF<h4>Background</h4>Estrogen receptor-negative breast cancers are clinically heterogeneous. Two subtypes, Luminal Androgen Receptor and Molecular Apocrine Breast Cancers, are both defined by androgen signaling but identified through distinct transcriptomic classifiers. Their relationship remains unclear despite overlapping …
Read PDFCardiac fibrosis driven by activated myofibroblasts is a central feature of pressure-overload heart disease. CD248 (Endosialin/TEM1) has been implicated as a pro-fibrotic marker in ischemic cardiac injury, but its role in pressure overload remains unclear. …
Read PDFGenomic integrity is constantly challenged by transcription/replication conflicts, a major source of replication stress and instability across all life forms. While extensive studies have elucidated mechanisms for resolving transcription/replication conflicts in animals, yeast, and prokaryotes, …
Read PDFTranscriptome analysis has become an increasingly reliable method to assess the response of microorganisms to the environment inside the host cell. However, to maximize the reading depth of the pathogen and host transcriptomes, physical separation …
Read PDF<h4>Background</h4>Melanoma shows one of the highest response rates to immune checkpoint inhibitors (ICIs), yet nearly half of patients experience primary or acquired resistance. While immune contexture strongly influences therapeutic efficacy, tumor cell-intrinsic features are increasingly …
Read PDF<h4>Background</h4>Citriculture holds significant socioeconomic importance but is adversely affected by diseases that reduce productivity. Plant disease resistance is typically relies on efficient defense mechanisms - PTI and ETI - involving PRR receptors and R genes …
Read PDFMultiple symptoms have been observed in COVID-19 patients, including migraine and facial pain which may result from the sensitization of the trigeminal ganglion (TG) and brainstem. Recent studies suggest that SARS-CoV-2 may invade trigeminal nerve …
Read PDFWhile normal adjacent tissue (NAT) is used as a standard control in cancer studies, NAT in close proximity to the tumor can display tumor-like molecular features, which are associated with a higher risk of local …
Read PDFInnate defenses of the respiratory epithelium are the first barrier against incoming respiratory viruses. To understand the contribution of both basal (tonic) and induced interferon (IFN) to antiviral defenses in a physiologically relevant system, we …
Read PDFInterpreting bulk RNA sequencing from heterogeneous tissues like the post-myocardial infarction (MI) heart is confounded by dynamic changes in cell-type composition. To address this, we developed a computational approach using single-nucleus RNA sequencing (snRNA-seq) references …
Read PDFThe prevalence of both osteoporosis and sarcopenia increases with age and about 60% of elderly sarcopenia patients also develop osteoporosis. However, the co-occurrence of osteoporosis and sarcopenia remains unclear. We performed single-cell 5' RNA-seq on …
Read PDFVasculogenic mimicry (VM) is the ability of cancer stem cells (CSCs) to express an endothelial-like phenotype and participate in tumor neovascularization via the formation of a blood-conducting, matrix-rich network. We previously reported that pancreatic ductal …
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