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DNA replication and transcription must be intricately coordinated as both machineries navigate the same chromatin landscape to ensure genome stability and proper cell function. Here, we show that altering their elongation rates-specifically, slowed transcriptional elongation …
Read PDFTranscriptomic profiling is a cornerstone of molecular biology and plays a central role in translational and molecular oncology, where reliable gene expression measurements are essential. Targeted RNA sequencing approaches offer several advantages over whole-transcriptome methods, …
Read PDFKaposi sarcoma (KS) is an AIDS-defining cancer and a significant global health challenge caused by KS-associated herpesvirus (KSHV). NGS-based approaches have profiled KS lesions in a minimal number of studies compared with other neoplastic diseases. …
Read PDFInsulin signaling regulates cellular metabolism in an epigenetic manner, but its role in the immune cell homeostasis remains unknown. High plasma insulin obstructs efficient insulin signaling and rewires metabolic activity in autoimmunity. In this study, …
Read PDF<h4>Purpose</h4>Chromatin-based repression is essential for retinal development, yet the genome-wide binding landscape of Polycomb repressive complex 2 (PRC2) in the developing retina has not been defined. In particular, how the PRC2 catalytic subunit EZH2 associates …
Read PDFBACKGROUND: Current helminth genomes possess thousands of predicted fusion genes, encoding novel protein domain architectures that are unique to these species. To investigate this, we analyzed 20,313 two-domain proteins annotated in current helminth genomes, of …
Read PDF<h4>Introduction</h4>The cellular mechanisms underlying Long COVID (LC) associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain poorly understood.<h4>Methods</h4>We performed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cells collected 12 months after acute COVID-19 infection from …
Read PDFAlthough genetic risk in coronary artery disease (CAD) is linked to changes in gene expression, recent discoveries have revealed a major role for A-to-I RNA editing in CAD. ADAR1 edits immunogenic double-stranded RNA (dsRNA), preventing …
Read PDFBlack Tiger shrimp (Penaeus monodon) underpins global aquaculture. However, it is periodically impacted by White Spot Syndrome Virus (WSSV). Because shrimp lack adaptive immunity, antiviral defense relies on innate pathways, including Toll, IMD, and JAK/STAT …
Read PDFA new subpopulation of polar bears (Ursus maritimus) was recently discovered in the South-East of Greenland. This isolated colony inhabits a warmer climate zone, akin to the predicted future environments of polar bears with vastly …
Read PDFSystemic sclerosis (SSc) is a fibrotic disease with high mortality. SSc-associated pulmonary fibrosis (SSc-PF) is currently the leading cause of death. SSc shows a significant sex disparity, with an average sex ratio of 1:5 men …
Read PDFLong-term memory (LTM) requires transcription and translation of new proteins, yet the transcriptional control of memory remains poorly understood. Here, we performed a transcriptome time-course during LTM formation in Drosophila melanogaster exposed to courtship conditioning. …
Read PDFUnnecessary antibiotic use is a major driver of antimicrobial resistance, an urgent public health threat. Acute respiratory infection (ARI) is a leading cause of inappropriate antibiotic use, creating an unmet need for improved diagnostics to …
Read PDFMicrosatellite instability (MSI) is becoming increasingly important in oncology as it has been reported across more than two dozen of solid cancer types. The MSI-high phenotype has long been used as a predictive and prognostic …
Read PDFImmunotherapy achieved remarkable results in patients with deficient mismatch repair (dMMR)/microsatellite instable (MSI) metastatic colorectal carcinoma (mCRC). However, its efficacy in proficient MMR (pMMR)/microsatellite stable (MSS) mCRC remains limited. In the phase II NIVACOR trial, …
Read PDFRoot knot nematodes (RKNs) induce galls, containing multinucleated giant cells (GCs) to nourish them. The differentiation of precursor cells to galls/GCs involves extensive cellular reprogramming with multiple layers of regulation. Epigenetic regulation during the early …
Read PDFArterial aging is a major risk factor for cardiovascular disease and is associated with progressive changes in vascular structure and function, including arterial stiffening, reduced elasticity, extracellular matrix remodeling, chronic low-grade inflammation, and accumulation of …
Read PDF<h4>Background</h4>The molecular characterisation of pediatric acute lymphoblastic leukemia (pALL) is essential for accurate diagnosis and risk stratification. However, standard-of-care (SoC) methods have limited sensitivity and resolution.<h4>Methods</h4>This study evaluates the clinical utility of emerging genomic technologies-including …
Read PDF<h4>Background/objectives</h4>Bitter taste perception is important for pig feeding behavior and survival. The type 2 taste receptors (T2Rs) are G protein-coupled receptors responsible for the sense of bitter taste perception in mammals. <i>T2Rs</i> are expressed in …
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