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Liver cancer (LC) is the second leading cause of cancer-related deaths globally, yet the molecular mechanisms linking its progression with associated risk factors (RFs) remain poorly understood. To address this, we developed an integrative multi-stage …
Read PDFRupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression. We examined the role of Twist1, a transcription factor that drives endothelial-to-mesenchymal …
Read PDFRespiratory viruses can infect hosts concurrently or sequentially, potentially influencing each other's pathogenic trajectory. However, the underlying immune mechanisms governing these interactions remain poorly understood. In this study, we examined whether respiratory syncytial virus (RSV) …
Read PDFTranscription initiation is a highly dynamic and tightly regulated process involving the coordinated action of transcription factors, chromatin remodelers, and RNA polymerase, which determine where and when transcription begins. Accurately mapping and quantifying transcription start …
Read PDFLeaf rust caused by Puccinia triticina is a yield limiting disease of cultivated wheat throughout the world. Ae. umbellulata is a diploid species of wheat wild relatives containing high genetic diversity for resistance to multiple …
Read PDFSplice-disrupting variants are estimated to account for one-third of disease-causing variants, yet many remain underrepresented in clinical databases due to limitations in detecting splicing changes beyond canonical splice sites. Short-read RNA sequencing (RNA-seq) has proved …
Read PDFTimothy is the most important perennial forage grass species in northern Norway, a region that is predicted to experience variable winter weather conditions due to climate change. Knowledge about how timothy cultivars respond to a …
Read PDFOvarian clear cell carcinoma (OCCC) is a chemoresistant subtype of epithelial ovarian cancer with limited therapeutic options and distinct molecular features. Histone methyltransferase SETD8 catalyzes the monomethylation of histone H4 at lysine 20 (H4K20me1) and …
Read PDF<i>Leishmania braziliensis</i> is the primary causative agent of American tegumentary leishmaniasis (ATL), a critical parasitic tropical neglected disease. The chemotherapeutic arsenal has limited efficacy and significant toxic effects that lead to an urgent need to …
Read PDF<h4>Abstract</h4>Our knowledge of which bone marrow (BM) cells affect red cell production is still incomplete. To explore the role of osteocytes in the process, we performed bulk RNA sequencing of osteocytes isolated from control and …
Read PDFWe present the first integrated transcriptomic and proteomic profiling of the iridocorneal region in the spontaneous murine glaucoma model DBA/2J and DBA/2J-Gpnmb<sup>+</sup>/Sj controls to define molecular changes associated with ocular hypertension and glaucoma. Using RNA …
Read PDFFuchs Endothelial Corneal Dystrophy (FECD) is an age-related disorder that affects about 4% of the population over the age of 40 years and is genetically associated with CTG repeat expansion in Transcription factor-4 (TCF4) gene. …
Read PDFRespiratory syncytial virus (RSV) is a seasonal pathogen known to cause lower respiratory tract infections, including bronchiolitis and pneumonia, and it is associated with an increased risk of developing asthma and recurrent wheezing in pediatric …
Read PDF<i>Caenorhabditis elegans</i> provides a tractable model for neural circuit studies, with complete connectomes and single-cell transcriptomic atlases available. Here, we present <i>Ce</i> -NeRV3D ( <i>C. elegans</i> Neuron RNA-seq Visualization tool in 3D), a Blender plug-in …
Read PDFPooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. Here we present MIC-Drop-seq, a technique that addresses these challenges by combining high-throughput CRISPR gene disruption …
Read PDFLymph nodes (LNs) along the murine gastrointestinal tract are immunologically distinct. Here, we investigate whether such an immune dichotomy globally defines gut LN identity and what drives the regional differences. However, we find that, transcriptionally, …
Read PDFGut function exhibits 24 h (circadian) rhythmicity, in part driven by intrinsic clocks within intestinal epithelial cells (IECs). The gut microbiome also demonstrates circadian rhythms in composition and function, important for maintenance of metabolic, immune …
Read PDFDrug-induced acute kidney injury (AKI) affects about 20 % of hospitalized AKI patients, a significant contributor to morbidity and mortality. The lack of understanding of the kidney system and functioning of nephrotoxic drugs contributes to …
Read PDFDespite having excellent prognosis when detected early, colorectal cancer (CRC) remains a leading cause of cancer-related deaths globally. Screening remains an important contributor to CRC survival, but the cost and invasiveness of traditional imaging methodologies …
Read PDF<h4>Background & aims</h4>Metabolic dysfunction-associated steatohepatitis (MASH) increasingly drives hepatocellular carcinoma (HCC) development. We characterized inflammatory infiltrates in liver biopsies from MASH patients who developed HCC versus controls to identify predictive immune signatures.<h4>Method</h4>Formalin-fixed paraffin-embedded (FFPE) liver …
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