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Macropharyngodon meleagris is a coral reef-dwelling, benthic predatory fish renowned for its striking coloration and distinctive body patterns. It exhibits pronounced sexual dimorphism and is characterized by the presence of prominent canine-like teeth. Here, we …
Read PDFRobust 3D tissue culture models to activate aged fibroblasts for cell-based therapies and identify regulators of such activation are still missing. In our previous study, we showed that aged fibroblasts can be activated simply through …
Read PDF<i>Pseudomonas aeruginosa</i> (Pa) is an important opportunistic pathogen that has many virulence factors expressed in a coordinated manner to cause infection. The PilY1 protein is a component of the type IV pili (T4P) but has …
Read PDFChronic obstructive pulmonary disease (COPD) is a progressive condition characterized by airway remodeling, including emphysema and fibrosis. Proteoglycans and their glycosaminoglycan (GAG) chains are key components of the extracellular matrix and may be altered as …
Read PDFProstate cancer is the most prevalent malignancy among men and is driven by multiple factors, including androgen signaling and its receptor. Long non-coding RNAs, such as PVT1, play key roles in cancer, particularly by regulating …
Read PDFEbola virus (EBOV) is among the most lethal human pathogens, yet effective treatment options remain limited. While extensive efforts have elucidated the functions of viral proteins, the temporal orchestration of host transcriptional responses-and their exploitation …
Read PDFBACKGROUND: Immune evasion is a critical determinant of cancer progression, yet mechanisms underlying early-stage acquisition of these capabilities remain poorly understood. This study builds an early lung adenocarcinoma mouse model to explore the key regulator …
Read PDF<h4>Objective</h4>Medulloblastoma (MB) is one of the most prevalent solid brain tumors in the pediatric population. Although hundreds of Differentially Expressed Genes (DEGs) have been identified as diagnostic molecules and therapeutic targets for Medulloblastoma (MB), the …
Read PDFStreptomyces are key contributors to soil microbiome function, known for their biosynthetic diversity. While advances in -omics technologies have improved our understanding of microbiome composition and metabolic potential, the mechanisms underpinning interspecies interactions remain poorly …
Read PDF<h4>Background</h4>Atypical teratoid rhabdoid tumors (ATRTs) are highly aggressive pediatric central nervous system tumors defined by the inactivation of the SMARCB1 gene. Despite the identification of three distinct molecular subtypes, each defined by unique clinical and …
Read PDFThe short-lived and rapidly aging African turquoise killifish, Nothobranchius furzeri GRZ is a unique model to study vertebrate aging. Current genomic and full-length transcriptomic sequencing lacks full gene annotations, resulting in poor mapping in bulk …
Read PDFTissue resident host responses to microbial infections in the respiratory tract are highly dynamic in space and time and rely on the interaction of a multitude of cell types. To model these multicellular responses reliably …
Read PDFWe seek to identify genes involved in Parkinson's disease (PD) by combining information across different experiment types. Each experiment, taken individually, may contain too little information to distinguish some important genes from incidental ones. However, …
Read PDF<h4>Background</h4>Parental contributions to offspring phenotype extend beyond genetic inheritance, encompassing non-genetic factors that influence early development. However, the interplay between maternal and paternal effects remains poorly understood. This study investigates these contributions in Eurasian perch …
Read PDFHeterotopic ossification (HO), the abnormal formation of bone in soft tissues, is a debilitating complication that occurs after severe burns, trauma, and joint replacement surgery. Current diagnostic methods detect HO only after substantial progression, limiting …
Read PDFOur understanding of the causal mechanisms of disorders such as anxiety and depression remains rudimentary. There is a pressing need to develop disease-modifying and preventative therapies that can be administered early and reduce symptom emergence. …
Read PDF<h4>Background</h4>In silico cell-type deconvolution from bulk transcriptomics data is a powerful technique to gain insights into the cellular composition of complex tissues. While first-generation methods used precomputed expression signatures covering limited cell types and tissues, …
Read PDFComplex RNA-protein networks play a pivotal role in the formation of many types of biomolecular condensates. How RNA features contribute to condensate formation, however, remains incompletely understood. Here, we integrate tailored transcriptomics assays to identify …
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