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<h4>Background</h4>Pediatric brain tumors are the leading cause of disease-related mortality in children, yet many aggressive tumors lack effective therapies. RNA splicing is a hallmark of cancer, but it has not yet been systematically studied in …
Read PDFMany cancers, including glioblastoma (GBM), show a male-biased incidence and associated worse outcomes<sup>1</sup>. The mechanisms that underlie this sex difference remain unclear but may involve an immune response<sup>2</sup> that is partly driven by sex hormones …
Read PDFCell fusion is a fundamental process in the development of many multicellular organisms, but its precise role in gene regulation and differentiation remains largely unknown. The Caenorhabditis elegans epidermis, which comprises multiple syncytial cells in …
Read PDFMany insects benefit from ancient nutrient-supplementing endosymbionts. While symbiont losses and replacements occur on evolutionary timescales, their dynamics remain enigmatic due to the lack of experimentally tractable systems. Here, we report on the experimental establishment …
Read PDF<h4>Background</h4>Metabolic dysfunction-associated steatotic liver disease (MASLD) progresses to metabolic dysfunction-associated steatohepatitis (MASH) and is a major cause of liver cirrhosis. Although liver inflammation is the hallmark feature of MASH versus MASLD, the involvement of the …
Read PDF<h4>Introduction</h4>Graves' disease (GD) is a classical autoimmune disorder caused by interactions between genetic susceptibility and immune dysregulation. However, the transcriptomic mechanisms underlying disease relapse and remission, particularly those involving alternative splicing (AS), remain poorly understood.<h4>Methods</h4>We …
Read PDFChronic inflammation plays a central role in the progression of both infectious and vascular diseases, yet its impact on endothelial cells (ECs), which form the interface between blood and tissue, remains poorly understood. Given their …
Read PDFVasculogenic mimicry (VM) refers to the capacity of cancer cells from aggressive tumors to form a set of sinuses and channels that mimic normal blood vessels and lack endothelial cells. The rapid growth of a …
Read PDFThe journal retracts the article titled "Duloxetine, an SNRI, Targets pSTAT3 Signaling: <i>In</i>-Silico, RNA-Seq and <i>In</i>-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief" [...].
Read PDFHuman cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and reveal changes involving neurodevelopmental disorders. Mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene are associated with Rett syndrome, …
Read PDFGram-negative bacteria are emerging as an important source of natural products with pharmaceutical potential. However, the limited availability of genetic tools for drug discovery and sustainable production of secondary metabolites remains a challenge. Burkholderia spp. …
Read PDFGene expression measurements of tissues, tumors, or cell lines taken over multiple time points are valuable for describing dynamic biological phenomena such as the response to growth factors. However, such phenomena typically involve multiple biological …
Read PDFCorneal wetting is the most common treatment for dry eye disease and is generally considered palliative. Here, we challenge this view by demonstrating that rewetting the desiccated cornea of an aqueous-deficient mouse model with the …
Read PDFEndogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting …
Read PDF<h4>Background</h4>HIV-tuberculosis (HIV-TB) coinfection poses a significant public health challenge among children in high-burden African regions. Most previous transcriptomic studies have concentrated on adults and non-African populations, primarily analyzing gene-level differential expression. This approach overlooks multi-isoform …
Read PDFRhabdosargus sarba, the goldlined seabream, is a euryhaline marine fish of great aquaculture potential. Genome sequencing and assembly of R. sarba was carried utilizing a multi-platform sequencing strategy that included long-read sequencing (PacBio HiFi), short-read …
Read PDFAlternative splicing is crucial in gene regulation, with significant implications in clinical settings and biotechnology. This review article compiles bioinformatics short-read RNA-seq tools for investigating differential splicing; offering a detailed examination of their statistical methods, …
Read PDF<h4>Background</h4>Gene fusions play a pivotal role in the pathogenesis and classification of hematologic malignancies. RNA sequencing (RNA-seq) has emerged as a powerful tool for detecting gene fusions; however, many clinical studies have focused on targeted …
Read PDFBACKGROUND: Most advanced melanomas initially respond to targeted therapy but eventually relapse. Increasing evidence suggests that drug-tolerant persister cells can adopt a reversible drug-refractory state and represent a key driver of therapeutic resistance. METHODS: We …
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