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The combination of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) has improved clinical outcomes in advanced renal cell carcinoma (aRCC), though therapeutic resistance remains a major challenge. We conducted single-cell transcriptomic analysis on …
Read PDFQuality control constitutes a critical component of any next-generation sequencing (NGS) pipeline; however, most existing pipelines emphasize technical quality assessment (e.g. read quality, alignment metrics, duplication rates) while overlooking other equally important dimensions, such as …
Read PDF<h4>Background</h4>The genes controlling lineage determination and differentiation tend to be essential for the development of acute myeloid leukemia (AML). Identifying novel target genes capable of promoting the differentiation and maturation of undifferentiated leukemia cells offers …
Read PDF<h4>Background</h4>Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterised by underdevelopment of left-sided cardiac structures. While genetic predisposition contributes to HLHS, the relevance of environmental stressors is increasingly recognised, yet the cellular …
Read PDFThe quantity of physiological data has grown exponentially, yielding insights into mechanisms of phenotypic and disease pathways. Among the powerful tools for physiological omics is the study of RNA, where broad sequencing of RNA leads …
Read PDF<i>Cannabis sativa</i> glandular trichomes (CsGT) are the primary sites of cannabinoid biosynthesis. They consist of a metabolically active head and a structurally supportive stalk. While the biosynthetic role of the head is well established, understanding …
Read PDF<h4>Background</h4>Virus yellows (VY) disease of sugar beet is caused by a complex of aphid-transmitted viruses, including beet mild yellowing virus (BMYV). Neonicotinoids have been used for preventing VY through aphid management, but with the recent …
Read PDF<h4>Background</h4>Previous studies have linked mutations in the Mediator complex, specifically Mediator 13 (Med13) and Mediator 13-like (Med13L), with both congenital heart defects and cardiovascular diseases. Med13 and Med13L are mutually exclusive paralogs within the kinase …
Read PDF<b>Background:</b> Background: Endometriosis affects 10% of women of reproductive age. Despite the well-known association between endometriosis and infertility, the mechanisms underlying this association remain to be elucidated. <b>Methods:</b> Implantation and pregnancy success rates were evaluated …
Read PDFGene knockout (KO) strain collections are important tools for discovery in microbiology. <i>Cryptococcus neoformans</i>, a human fungal pathogen, has an available genome-wide gene deletion collection that is widely used by the research community. We uncovered …
Read PDF<i>Trypanosoma cruzi,</i> the causative agent of Chagas disease, presents a major public health challenge in Central and South America, affecting approximately 8 million people and placing millions more at risk. The <i>T. cruzi</i> life cycle …
Read PDF<h4>Background</h4>The honey bee parasite, Varroa destructor, is a globally devastating pest. Our previous experiments with laboratory mini-hives of bees and Varroa have shown an RNA interference biopesticide consisting of double-stranded RNA specific in sequence to …
Read PDFLocalized protein translation enables spatially restricted cellular dynamics, particularly in neurons, where specific mRNAs are translated in axons and dendrites far from the cell body. Translating ribosome affinity purification (TRAP) has been used to study …
Read PDFThe immunological composition of the microenvironment has shown relevance for diagnosis, prognosis, and therapy in solid tumors but remains underexplored in acute leukemias. We investigated the significance of the acute myeloid leukemia (AML) bone marrow …
Read PDF<h4>Introduction</h4>Tauopathies are a group of neurodegenerative diseases characterized by the pathological accumulation of tau protein. The hippocampus, a brain region crucial for learning and memory, is particularly susceptible to tau-induced damage. However, the molecular mechanisms …
Read PDFCytotoxic CD8 T lymphocytes (CTLs) and natural killer (NK) cells share the common objective of controlling infections and detecting and removing tumor cells, albeit through distinct target recognition mechanisms. Although CTLs belong to the adaptive …
Read PDFIn contrast to humans, fish can fully regenerate their hearts after cardiac injury. However, not all fish have the same regenerative potential, allowing comparative inter-species and intra-species analysis to identify the mechanisms controlling successful heart …
Read PDFStudies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells prior …
Read PDF<b>Background:</b> Clear cell renal cell carcinoma is considered an immunologically "hot" tumor, with an abundance of tumor-infiltrating immune cells. This feature has a strong effect on therapeutic outcomes, especially in immune therapies. Within this context, …
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