Search the literature by keyword, topic, or author. Filter to articles with full text available.
2701 results
Extrachromosomal circular DNA (ecDNA) has emerged as a critical determinant of poor clinical outcomes and immune escape in tumors, but the high cost and technical complexity of current detecting techniques limit its broader investigation in …
Read PDFAlternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism implicated in various diseases. Existing APA analysis tools are generally restricted to site detection and comparison, precluding differently expressed gene (DEG) analysis. Furthermore, standard RNA-seq-based DEG …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, accounting for more than 900,000 deaths a year worldwide. Microbial dysbiosis, including the presence of oral bacteria in the gut, has been linked to …
Read PDF<h4>Background</h4>LncRNAs emerge as critical regulators of gene expression and epigenetic modulation in human cancer. However, the biological and clinical significance of the lncRNA <i>GAS8-AS1</i> in differentiated thyroid cancers (DTCs) remains poorly understood.<h4>Methods</h4><i>GAS8-AS1</i> expression in normal …
Read PDFTranscriptome atlases can be used to examine the spatiotemporal dynamics of gene expression, thereby enabling the generation of genome-wide resources for understanding complex biological processes. In the silkworm <i>Bombyx mori</i>, transcriptomes serve as crucial datasets …
Read PDF<h4>Background</h4>Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level, disease-responsive candidate biomarkers for DCM …
Read PDFGlucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucocorticoids being essential for life, zF dysfunction perturbs multiple organs that …
Read PDFAcross cell types and organisms, thousands of RNAs display asymmetric subcellular distributions. Studying this process requires quantifying abundances of specific RNAs at precise subcellular locations. To analyze subcellular transcriptomes, multiple proximity-based techniques have been developed …
Read PDF<h4>Background</h4>Fibrosis is a common complication in Crohn's disease (CD), often leading to intestinal strictures. This study aims to explore the transcriptomic signature of fibrostenotic ileal CD for a comprehensive characterization of biological and cellular mechanisms …
Read PDFZinc is recognized as an important component of immune function in animals, operating through many different mechanisms. Metal transporter Zip14 (Slc39a14) is up-regulated during pro-inflammatory conditions and increases zinc uptake into cells, including enterocytes. As …
Read PDFColeoid cephalopods are excellent models for evolutionary and developmental studies due to their centralized nervous system, short life span, and sophisticated sense organs. Arm suckers, essential for predation, manipulation, and locomotion, have been studied in …
Read PDFNMDA receptor dysfunction is implicated in the pathophysiology of autism spectrum disorder (ASD). Here, we investigated heterozygous mouse mutants carrying the ASD-linked C456Y mutation of <i>Grin2b</i>, a high-confidence ASD risk gene encoding the GluN2B subunit …
Read PDFBRCA1 is a critical tumor suppressor, mutations in which greatly increase risks for many tumors in carriers, most notably breast cancer. Luminal progenitor cells (LPs) are the currently recognized cells of origin of BRCA1-deficient breast …
Read PDFThe identification of cell surface markers specific to pancreatic islet cell subsets is important for both the study of islet biology and for investigating the pathophysiology of diseases in which these cell types are lost …
Read PDF<h4>Background</h4>Traditional short-read RNA-Seq analysis pipelines predominantly focus on protein-coding genes, often overlooking other genomic sequences such as transposable elements (TEs) and non-coding RNA dynamics and do not usually investigate splicing events or transcript usage. To …
Read PDF<h4>Introduction</h4>Human fungal infections affect billions of people and result in more than 2 million deaths every year, however, they have historically been neglected as a cause of infectious disease-related deaths worldwide. Fungal drug resistance has …
Read PDFSome pancreatic ductal-type (PDADK) and lung adenocarcinomas (LADK) lacking other molecular drivers are reported to harbor <i>NRG1</i> fusions as potential novel therapeutic targets. We investigated the feasibility of a fluorescent in situ hybridization (FISH)-based diagnosis …
Read PDFMutations or polymorphisms in GRN, encoding the CNS glycoprotein progranulin (PGRN), have been linked to several neurodegenerative diseases. In this study, we explored the role of PGRN in prion diseases. We observed that prion infection …
Read PDFAltered immune states at the time of cancer diagnosis remain insufficiently characterized. Although circulating immune biomarkers offer a promising, non-invasive way of analysing systemic tumour-host interactions, their potential remains poorly defined. Here, we present an …
Read PDF<h4>Rationale</h4>High-grade T1 (HGT1) Non-Muscle Invasive Bladder Cancer (NMIBC) is a clinically heterogeneous disease characterized by unpredictable treatment responses and limited tools for recurrence prediction. Despite advances in molecular classification, patient stratification still relies mainly on …
Read PDF