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Bladder cancer (BLCA) is a common malignancy of the urinary system, yet the therapeutic relevance of transient receptor potential cation channel subfamily M member 4 (TRPM4) remains unclear. By integrating single-cell and whole-genome transcriptomic data, …
Read PDF<h4>Purpose</h4>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe type of drug reaction that has significant mortality rate. Traditional treatments, including glucocorticoids and immunosuppressants, are sometimes insufficient. We present a case of severe …
Read PDFEnhancers play an important role in transcriptional regulation by modulating gene expression from distal genomic locations. Although single-cell ATAC and RNA sequencing (scATAC/RNA-seq) data have been leveraged to infer enhancer-gene links, establishing regulatory links between …
Read PDFThis study aims to conduct an in-depth analysis of single-cell transcriptome data from synovial fibroblast differentiation in knee osteoarthritis (KOA), identify key target genes and underlying molecular mechanisms, and provide molecular-level theoretical support for clinical …
Read PDFAutism spectrum disorder (ASD) is a neurodevelopmental condition characterized by genetic heterogeneity. Post-transcriptional regulation-particularly alternative polyadenylation (APA)-plays a critical role in the pathogenesis of ASD. APA controls mRNA stability, translational efficiency, and subcellular localization through …
Read PDF<h4>Background</h4>Cardiovascular mortality remains predominantly driven by acute myocardial infarction (AMI), necessitating comprehensive elucidation of mechanisms governing cardiomyocyte reprogramming for therapeutic advancement. Characterizing molecular dynamics throughout cardiac repair processes presents substantial methodological challenges.<h4>Methods</h4>We employed a comprehensive …
Read PDFThe mortality rate of ovarian cancer remains disproportionately high compared with its incidence. This is partly due to a high level of intratumoral heterogeneity, driven by genomic instability, that promotes disease recurrence and treatment failure. …
Read PDFBACKGROUND: Ovarian cancer (OC) is the most lethal of gynecological cancers and presents a poor prognosis due to difficulty in early diagnosis, extensive abdominal metastasis and chemo-resistance. We utilized single-cell transcriptomics to deconvolute intratumoral heterogeneity …
Read PDFA clear mechanistic understanding of the skeletal system's physiological and pathological processes is essential for therapeutic research. Traditional bulk analysis methods cannot resolve cellular heterogeneity and dynamic intercellular signaling in bone microenvironments, limiting insights into …
Read PDFBone is a common site for cancer metastasis, yet the mechanisms driving human spinal bone metastases (BMs) are poorly understood. Here, we obtained a single-cell RNA sequencing (scRNA-seq) atlas of 62 BMs across 13 different …
Read PDFOvarian cancer is one of the leading causes of cancer-related mortality among women and remains exceptionally difficult to manage and treat effectively in the clinic. Fragile X-related protein 1 (FXR1) is highly amplified and overexpressed …
Read PDFAlthough the spleen is a key immune organ, the dynamic remodeling of its cellular landscape during development and the heterogeneous immune responses of these cells to avian Salmonella infection remain to be elucidated. In this …
Read PDFNeuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA-seq) has been widely used …
Read PDF<h4>Background</h4>Breast cancer is a molecularly heterogeneous disease composed of multiple intrinsic subtypes. Recent studies have highlighted the substantial intratumor heterogeneity of breast cancer, wherein malignant cells of distinct intrinsic subtypes co-exist within the same tumor. …
Read PDFSex is one of the most fundamental biological variables, with a profound impact on tumor incidence, mortality, treatment response and prognosis, making it a critical consideration for precision oncology. Despite its well-established role in tumors, …
Read PDF<h4>Introduction</h4>Atherosclerosis, a chronic inflammatory arterial disease, involves complex interactions among diverse immune cells. Although single-cell RNA sequencing (scRNA-seq) has revealed cellular heterogeneity within atherosclerotic lesions, the diversity of neutrophils and their crucial genes in atherogenesis …
Read PDFLaryngeal squamous cell carcinoma (LSCC) is typically diagnosed at advanced stages, highlighting the critical need for early intervention. By integrating single-cell and bulk RNA-seq data from LSCC, vocal cord leukoplakia (VCL), and LSCC precursors, we …
Read PDF<b>Background:</b> In some children with immunodeficiency, Bacille Calmette-Guérin (BCG) vaccination can lead to dissemination and severe infection, including severe intracranial infection, called disseminated BCG disease (BCGosis), which is characterized by high rates of disability and …
Read PDFNeonatal necrotizing enterocolitis (NEC) continues to be the most severe gastrointestinal emergency affecting preterm infants, with reported mortality rates ranging from 20% to 30%. The absence of distinct early biomarkers results in delayed intervention and …
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