Correction: Transcriptome profiling of intrahepatocytic <i>Plasmodium</i> and their host hepatocytes based on the infection phase and the zonation of the liver
[This corrects the article DOI: 10.3389/fgene.2025.1548487.].
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Integrating Multi-Omics and Medical Imaging in Artificial Intelligence-Based Cancer Research: An Umbrella Review of Fusion Strategies and Applications
<b>Background:</b> The combination of multi-omics data, including genomics, transcriptomics, and epigenomics, with medical imaging modalities (PET, CT, MRI, histopathology) has emerged in recent years as a promising direction for the advancement of precision oncology. Many …
Read PDFMultiomics approaches in Kawasaki disease: insights into pathogenesis and emerging directions for diagnosis and treatment
Kawasaki disease (KD) is an acute febrile vasculitis and the leading cause of acquired heart disease in children. Despite decades of research, the etiology remains unknown and key mechanisms linking systemic inflammation to coronary artery …
Read PDFAdvancements in Pathogenic Genes and Biomarkers for Non-syndromic Cleft Lip With or Without Cleft Palate Via Multiomics
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common congenital malformation influenced by a combination of environmental and genetic factors. nsCL/P is usually diagnosed using fetal ultrasound during the late second trimester; …
Read PDFMulti-omics biomarkers for predicting resistance, hyperprogression, and immune-related toxicity during PD-1/PD-L1 therapy in lung cancer: a literature review
Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) have transformed the management of advanced lung cancer, yet most patients experience primary resistance, hyperprogressive disease (HPD), or …
Read PDFMultiomics Data Synthesis of FAM83H in Amelogenesis Imperfecta
<h4>Objectives</h4>FAM83H is a critical gene implicated in amelogenesis imperfecta type IIIA (AI type IIIA), but its precise role in enamel formation remains poorly understood. Fragmented datasets, inconsistent terminology, and limited integrative analyses hinder functional interpretation. …
Read PDFCurrent Overview of Multi-omics Analyses in Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease characterized by autoantibodies against neutrophil cytoplasmic antigens such as myeloperoxidase (MPO) and proteinase 3 (PR3). AAV affects small blood vessels, leading to systemic inflammation and multiorgan …
Read PDFNavigating the molecular landscape: integrated multiomics liquid biopsy for biomarker discovery in early detection and monitoring of colorectal cancer
The elevated mortality associated with colorectal cancer is largely due to delayed diagnosis and post-treatment disease recurrence, highlighting the urgent clinical need for molecular markers with exceptional sensitivity and specificity to support early detection and …
Read PDFUnveiling Plant Metabolic Diversity: Integrating Metabolomics with Multi-Omics Approaches for Crop Improvement
Metabolomics, representing the biochemical phenotype of cells or tissues, serves as an intrinsic factor underlying the differences in plant traits. Recent advances in multi-omics technologies have significantly deepened our understanding of plant metabolic diversity, enabling …
Read PDFEucaMOD: a comprehensive multi-omics database for functional genomics research and molecular breeding of fast-growing eucalyptus trees
Eucalyptus, one of the most widely planted plantation tree species globally, is primarily found in tropical and subtropical regions and contributes significantly to economic and social benefits. With advances in sequencing technologies, there is an …
Read PDFHigh-depth RNA-seq data to investigate gene regulation mediated by phase-variable DNA methyltransferases in serogroup B <i>Neisseria meningitidis</i>
<i>Neisseria meningitidis</i> is a leading cause of bacterial meningitis and septicemia. Here, we report high-depth RNA-seq for <i>N. meningitidis</i> serogroup B strains MC58, B6116/77, and M0579. These strains encode phase-variable DNA methyltransferases ModA11, ModA12, and …
Read PDFUnderstanding and Advancing Wound Healing in the Era of Multi-Omic Technology
Wound healing is a complex, multi-phase process requiring coordinated interactions among diverse cell types and molecular pathways to restore tissue integrity. Dysregulation can lead to chronic non-healing wounds or excessive scarring, posing major clinical and …
Read PDFDeciphering Pesticide Stress Responses in Rice Through Integrated Multi-Omic Assessment
Pesticides are widely used in rice cultivation for pest control to guarantee crop productivity. Intensive use of these chemicals causes harmful effects on rice plants, such as physiological and biochemical stress responses. Such stress is …
Read PDFIntegrating multi-omics approaches in acute myeloid leukemia (AML): Advancements and clinical implications
Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive hematologic malignancy characterized by clonal proliferation of myeloid precursors. Despite significant advancements in genomic profiling and targeted therapies, patient outcomes remain suboptimal due to disease …
Read PDFIntegrative multi-omics profiling for early diagnosis, stratification and personalized management of chronic kidney disease: a new paradigm
Chronic Kidney Disease (CKD) is a progressive condition characterized by the gradual loss of renal function over time, affecting millions worldwide and representing a significant public health challenge. CKD is associated with increased morbidity and …
Read PDFResearch progress of omics technologies in forage breeding
Forages are essential to global agriculture and ecosystems, with the development of high-yield, high-quality varieties as a cornerstone of efficient agricultural practices. However, traditional genetic breeding methods, characterized by lengthy cycles and limited efficiency, fall …
Read PDFMulti-omics-driven biomarker discovery in autoimmune diseases: a comprehensive review
Autoimmune diseases (ADs) exhibit complex heterogeneity and dynamic pathological mechanisms. Traditional biomarkers face numerous challenges in the diagnosis and treatment of ADs. However, the rapid development of multi-omics technologies and bioinformatics has not only deepened …
Read PDFAdvancements in bone marrow biopsy: the role of omics and artificial intelligence in hematologic diagnostics
Bone marrow biopsy remains central to the diagnosis, classification, and monitoring of hematologic disorders, providing essential morphologic and immunophenotypic information. However, conventional assessment is limited by interobserver variability and an inability to fully capture the …
Read PDFMulti-omics approaches to major psychiatric disorders
In recent years, major psychiatric disorders have been intensively researched. Studies have investigated the pathophysiology of these disorders in detail and at various molecular levels with several omics techniques, including genomics, epigenomics, transcriptomics, proteomics, and …
Read PDFLongevity Aesthetics: A Conceptual Framework for Integrating Pro-Aging Medicine Into Surgical and Nonsurgical Practice
The prevailing paradigm in aesthetic medicine is the "antiaging" model, which focuses on correcting and/or reversing visible signs of aging. However, contemporary geroscience reconceptualizes aging as a malleable biological process driven by defined hallmarks, offering …
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