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Cutaneous melanoma represents a paradigm of immunological complexity, where multifactorial primary and acquired resistance often undermine the clinical efficacy of conventional immune checkpoint blockades and targeted therapies. This review provides a comprehensive analysis of the …
Read PDFGastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with most cases diagnosed at advanced stages. Traditional biomarkers provide only partial insights into GC's heterogeneity. Recent advances in machine learning (ML)-driven …
Read PDFSpinal cord injuries are often devastating and result in severe functional limitations. Our review breaks down the pathophysiology, molecular mechanisms, and omics approaches regarding spinal cord injuries. The pathophysiology can be divided into two main …
Read PDFWith the advancement of novel technologies such as whole-genome sequencing, single-cell sequencing, and spatial transcriptomics, single-omics analyses have already promoted the research of tumorigenesis as well as development and have partly elucidated the evolutionary processes …
Read PDFThe inhibitor of DNA-binding 3 (ID3) plays a crucial role in DNA double-strand break (DSB) repair. We previously reported that ID3 loss reduced chromatin accessibility at DNA repair gene promoters, yet its exact role in …
Read PDFIn the last two decades, technological interventions have played a significant role in transforming healthcare with timely diagnosis and novel therapeutic interventions. Advanced technologies such as next-generation sequencing, NMR, mass spectrometry, and non-invasive imaging modalities …
Read PDFMelanin pigments are ubiquitous biopolymers across diverse life forms and play multifaceted roles in cellular defense and environmental adaptation. The specialized neuromelanin in human brains accumulates mainly within catecholaminergic neurons of the substantia nigra and …
Read PDFMini-livestock refers to small vertebrates and invertebrates used as human food, animal feed, or for other beneficial purposes. They represent sustainable alternatives to conventional livestock, whose potential is now being revealed through advances in omics …
Read PDFRheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by variable clinical manifestations and a complex, often unpredictable disease trajectory, which hinders early diagnosis and personalized treatment. This review highlights recent breakthroughs in biomarker discovery, …
Read PDFRheumatoid arthritis (RA) is a multifaceted autoimmune disease that is marked by a complex molecular profile influenced by an array of factors, including genetic, epigenetic, and environmental elements. Despite significant advancements in research, the precise …
Read PDFOral squamous cell carcinoma (OSCC) remains a formidable challenge in modern medicine, threatening enormous number of lives worldwide. Although research is offering an exponential growth as numbers of molecular pathways, biomarkers, and potential therapeutic targets …
Read PDFThe metastatic tumor microenvironment (TME) is a highly dynamic and heterogeneous ecosystem that plays a critical role in promoting cancer cell colonization, immune escape, and resistance to therapy. Recent advances in multi-omics technologies-including genomics, transcriptomics, …
Read PDFParkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the …
Read PDF<h4>Background</h4>Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting the urgent need for earlier detection within real-world screening and patient management pathways. Recent advances in multi-omics technologies have created new opportunities for identifying …
Read PDFEndometriosis affects an estimated 5-10% of women of reproductive age and presents with substantial clinical and biological heterogeneity. Recent clinical guidelines have shifted toward symptom-guided diagnosis supported by expert imaging, moving away from mandatory diagnostic …
Read PDFIntra-tumoral heterogeneity (ITH) is common in malignant tumors and arises from dynamic variations across genetic, epigenetic, transcriptomic, proteomic, metabolic, and microenvironmental factors. This complexity drives tumor evolution and treatment resistance, undermining the accuracy of clinical …
Read PDFHenoch-Schönlein purpura (HSP) is a common autoimmune disease in children. The lesions primarily involve small vessels in the skin, kidneys, joints and intestines. Henoch-Schönlein purpura nephritis (HSPN) caused by HSP is the main factor affecting …
Read PDFSingle-cell omics technology has advanced rapidly since its inception, offering increasing precision, resolution, and technical diversity to explore cell-specific molecular features in the human brain and neuropsychiatric disorders. While traditional bulk genomic analyses have provided …
Read PDFImmune checkpoint inhibitors (ICIs) have reshaped oncology, yet overall response rates remain modest and resistance is common, driven by tumor heterogeneity and evolving tumor-immune crosstalk. Established biomarkers (PD-L1, tumor mutational burden, microsatellite instability) provide incomplete …
Read PDFType 2 diabetes (T2D) is a complex, multifactorial metabolic disorder, and while bariatric surgery has emerged as a promising intervention for obesity-related T2D with significant metabolic benefits, its long-term durability and potential for remission vary …
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