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Cancer database is a systematic collection and analysis of various human cancer information at the genomic and molecular levels, which can be used to understand the mechanisms of cancer occurrence and development, and facilitate the …
Read PDFPharmacogenomics is entering a transformative phase as high-throughput "omics" techniques become increasingly integrated with state-of-the-art artificial intelligence (AI) methods. Although early successes in single-gene pharmacogenetics reported clear clinical benefits, many drug response phenotypes are governed …
Read PDFVitamin K2 refers to a subfamily of vitamin K isoforms known as Menaquinones and, therefore, indicated as MK-n, the "n" indicating the number of isoprene units present in the side chain. Like the other members …
Read PDFGliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high-throughput technologies have …
Read PDF<h4>Background</h4>Breast cancer (BC) is a critical cause of cancer-related death globally. The heterogeneity of BC subtypes poses challenges in understanding molecular mechanisms, early diagnosis, and disease management. Recent studies suggest that integrating multi-omics layers can …
Read PDFAntibiotic resistance (AR) has long been interpreted through the lens of genetic mutations and horizontal gene transfer. Yet, mounting evidence suggests that epigenetic regulation, including DNA and RNA methylation, histone-like proteins, and small non-coding RNAs, …
Read PDFCancer immunotherapy has revolutionized clinical oncology; however, the inherent complexity and heterogeneity of cancer present substantial challenges to achieving broad therapeutic efficacy. Tumor heterogeneity manifests not only among different patients but also within individual tumors, …
Read PDFRapid advancement of sequencing technologies now allows for the utilization of precise signals at single-cell resolution in various omics studies. However, the massive volume, ultra-high dimensionality, and high sparsity nature of single-cell data have introduced …
Read PDFDiabetes mellitus (DM) comprises distinct subtypes-including type 1 DM, type 2 DM, and gestational DM - all characterized by chronic hyperglycemia and substantial morbidity. Conventional diagnostic and therapeutic strategies often fall short in addressing the …
Read PDFIndividuals with Down syndrome (DS) are highly susceptible to Alzheimer's disease (AD). The integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics enables unprecedented understanding of DS-AD, offering a detailed picture of this complex issue. The …
Read PDFHepatocellular carcinoma (HCC) remains a significant global health challenge, with therapeutic efficacy in advanced stages often limited by underlying liver dysfunction and adaptive resistance. In this review, the evolving landscape of molecular targets and combinatorial …
Read PDFRett syndrome (RTT) is a severe neurodevelopmental disorder primarily affecting females, caused by mutations in the X-linked gene <i>MECP2</i>. This gene encodes methyl CpG binding protein 2 (MeCP2), a multifunctional epigenetic regulator critical for neuronal …
Read PDFWhen using traditional approaches, such as pharmacokinetics and pharmacodynamics, the entire cellular or molecular response to drugs in the body cannot be fully ascertained or established. The oral medication process involves pharmacokinetics, followed by oral …
Read PDFThe convergence of high-resolution multi-omics technologies with computational systems biology is transforming plant physiology by enabling predictive, mechanistic, and field-relevant insights into crop performance, adaptation, and resilience. This review presents an integrative and forward-looking synthesis …
Read PDFRecent advances in multi-omics and spatial proteomics are reshaping our understanding of Alzheimer's disease. Guo et al.<sup>1</sup> applied integrative multi-omics to stratify mild cognitive impairment into biologically distinct subtypes with divergent progression trajectories: one metabolically …
Read PDFBreast cancer remains a major global health issue, requiring novel strategies for prognostic evaluation and therapeutic decision-making. In this study, we leverage multi-omics data from The Cancer Genome Atlas to obtain deeper insights into breast …
Read PDFSingle-cell sequencing enables genome- and epigenome-wide profiling of thousands of individual cells, offering unprecedented biological insights. However, technical noise and batch effects obscure high-resolution structures, hindering rare-cell-type detection and cross-dataset comparisons. To comprehensively address these …
Read PDFDiabetes mellitus presents complex constellation of multiple long-term conditions (MLTCs) including cardiovascular, renal, metabolic, and neuroinflammatory disorders. This leads to clinical heterogeneity, polypharmacy, therapeutic disinterest, adverse outcomes, societal challenges, and glycaemic control management strategies. Precision …
Read PDFCardiometabolic diseases, encompassing obesity, insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), hypertension, and atherosclerotic cardiovascular disease (ASCVD), represent a vast continuum driven by multi-organ network dysregulation. Clinical risk assessment remains …
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