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Pituitary neuroendocrine tumors (PitNETs) are a heterogeneous group of intracranial neoplasms that vary in hormonal activity, histological features, and clinical behavior. The rise of high-throughput sequencing and molecular profiling technologies has enabled multiomic approaches-including genomics, …
Read PDFImmune checkpoint inhibitors (ICIs) have transformed oncology, yet durable benefit remains confined to a minority of patients, revealing the limitations of single biomarkers such as PD-L1 expression, tumor mutational burden, and microsatellite instability. Multi-omics profiling, …
Read PDFImmunotherapy has revolutionized hematologic cancer treatment, yet responses remain unpredictable due to primary resistance, relapse, and life-threatening toxicities. Conventional biomarkers fail to capture the complexity of tumor-immune interactions, necessitating integrative approaches. This review explores how …
Read PDFThe human endometrium undergoes dynamic changes across the menstrual cycle to establish a receptive state for embryo implantation. Using bulk and single-cell RNA-Seq, we characterized gene expression dynamics in the cycling endometrium and the decidua …
Read PDFSpatial transcriptomics, proteomics, and epigenomics are innovative technologies which offer an unparalleled resolution and wealth of data in understanding and the interpretation of cellular functions and interactions. These techniques allow researchers to investigate gene and …
Read PDFGlioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. It is characterized by a high degree of heterogeneity, meaning that although these tumors may appear morphologically similar, they often exhibit distinct …
Read PDFThe integration of artificial intelligence (AI) into next-generation sequencing (NGS) has revolutionized genomics, offering unprecedented advancements in data analysis, accuracy, and scalability. This review explores the synergistic relationship between AI and NGS, highlighting its transformative …
Read PDFThe rapid evolution of single-cell sequencing technologies has significantly advanced our knowledge of cellular heterogeneity and the underlying molecular basis in healthy and diseased kidneys. While single-cell transcriptomic analysis excels in characterizing cell states in …
Read PDFArtificial intelligence (AI) excels at efficiently processing large volumes of data and extracting valuable insights. Deep Learning (DL), a subfield of AI, utilizes multi-layer neural network algorithms to analyze various types of data, mimicking the …
Read PDFColorectal cancer (CRC) is a common malignant tumor with a high mortality rate worldwide. Advanced CRC often leads to liver metastasis, which has a poor prognosis, highlighting the need to investigate the underlying mechanisms. Omics, …
Read PDFcis-Regulatory elements (cREs) are essential for the spatio-temporal control of gene expression during development and disease. However, cRE activity is highly dependent on cell and tissue type. The developing heart is composed of several cell-types, …
Read PDFAging is the main determinant of chronic diseases and mortality, yet organ-specific aging trajectories vary, and the molecular basis underlying this heterogeneity remains unclear. To elucidate this, we integrated genomic, epigenomic, transcriptomic, proteomic, and metabolomic …
Read PDFBACKGROUND: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling and right ventricular failure. Endothelial dysfunction plays a key role in PAH initiation and progression. Recent studies have implicated epigenetic dysregulation, particularly histone acetylation, …
Read PDFThe expansion of multi-omics datasets raises significant challenges for data integration and querying. To overcome these challenges, we developed a generic RDF-based integration schema that connects various types of differential -omics data, epigenomics, and regulatory …
Read PDF<h4>Background</h4>Aggressive Variant Prostate Cancers (AVPCs) are incurable malignancies. Platinum-based chemotherapies are used for the palliative treatment of AVPC. The Polycomb Repressive Complex 2 (PRC2) promotes prostate cancer progression <i>via</i> histone H3 Lysine 27 tri-methylation (H3K27me3). …
Read PDF<h4>Background</h4>Rapid advances in biotechnology provide researchers with the opportunity to integrate omics profiles (genomics, epigenomics, transcriptomics, proteomics, etc.) with multiple phenotypes or experimental conditions. In cancers such as acute myeloid leukemia (AML), where combination therapies …
Read PDFOver the past few decades, technological advancements and declining costs of high-throughput data generation have revolutionized biomedical research, enabling the collection of large-scale datasets across multiple omics layers-including genomics, transcriptomics, proteomics, metabolomics, and epigenomics. The …
Read PDFEarly life adversity (ELA) is associated with subsequent mental health problems, and animal studies provide evidence for a causal role of ELA in the risk for mental illness, including persistent brain changes at molecular, cellular, …
Read PDFMitochondrial Ca<sup>2+</sup> uptake via the mitochondrial Ca<sup>2+</sup> uniporter (MCU) following store-operated Ca<sup>2+</sup> entry supports cellular bioenergetics, yet how mitochondria shape store-operated Ca<sup>2+</sup> entry and cytosolic Ca<sup>2+</sup> signaling remains incompletely understood. Combining gene deletion and functional …
Read PDFAge-related hearing loss is a prevalent and growing public health issue among the elderly. Here, we perform a multi-ancestry genome-wide association study comprising 456,613 cases and 1,053,834 controls, identifying 140 independent loci associated with age-related …
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