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Metabolic syndrome and excessive alcohol consumption (MetALD) result in liver injury and fibrosis, which are driven by increased collagen production by activated hepatic stellate cells (HSCs). Our previous studies demonstrated that LARP6, an RNA-binding protein, …
Read PDFThe rapid and accurate diagnosis of rare diseases is paramount in directing clinical management. In recent years, the integration of multi-omics approaches has emerged as a potential strategy to overcome diagnostic hurdles. This review examines …
Read PDFBladder cancer (BC) is one of the most prevalent types of cancer in developed countries. BC is characterized by its highly heterogeneous and dynamic nature, with significantly higher morbidity and mortality rates in men compared …
Read PDFSpatial omics integrates molecular profiling with spatial tissue context, enabling high-resolution analysis of gene expression, protein interactions, and epigenetic modifications. This approach provides critical insights into disease mechanisms and therapeutic responses, with applications in cancer, …
Read PDFRNA methylation, particularly N6-methyladenosine (m<sup>6</sup>A) and 5-methylcytosine (m<sup>5</sup>C), functions as a pivotal post-transcriptional regulatory mechanism and plays a central role in plant growth, development, and stress responses. This review provides a systematic summary of recent …
Read PDFRecent advancements in cancer multi-omics have transformed our understanding of cancer biology by integrating genomics, transcriptomics, proteomics, and metabolomics. These integrative approaches have led to the identification of novel biomarkers and therapeutic targets, offering deeper …
Read PDFRenal cell carcinoma (RCC) exhibits marked heterogeneity in its molecular landscape and clinical behavior. Ferroptosis, an iron-dependent and lipid peroxidation-driven form of cell death, has emerged as a biologically relevant process in RCC pathogenesis. This …
Read PDFPeople living with HIV (PLHIV) have an increased susceptibility to non-AIDS comorbidities. In this study, we systematically profiled 1,342 PLHIV across five omics layers and immune function. We found latent factors, resulting from integrating epigenomics, …
Read PDFBACKGROUND: Enhancer of Zeste Homolog 2 (EZH2) is highly expressed in various cancers and is thought to contribute to cancer malignancy through the methylation of lysine 27 on histone H3 (H3K27). Therefore, EZH2 is an …
Read PDFGoose astrovirus (GAstV) infection has emerged as a prevalent cause of urate deposition and viral gout in major goose farming across China, leading to high mortality and substantial economic losses. However, the molecular mechanisms linking …
Read PDFIn recent years, with the continuous development of single-cell sequencing (sc-seq) technology, Sc-seq can conduct high-throughput and high-resolution transcriptome analysis at the single-cell level, revealing gene expression differences and molecular characteristics among individual cells. This …
Read PDFOesophageal squamous cell carcinoma (ESCC) represents a major global health burden, particularly in regions with high incidence rates, significantly affecting patient quality of life and survival outcomes. Recent advances in multi‑omics technologies have highlighted their …
Read PDFOver the past decade, poultry genomics has undergone a transformative shift from genome assembly to functional annotation, mechanistic discovery, and integrative applications that advance sustainable poultry production. This symposium highlights emerging tools and resources that …
Read PDFTumor drug resistance represents a major challenge in contemporary cancer therapeutics, significantly compromising the clinical efficacy of chemotherapy, targeted therapy, and immunotherapy. While existing research has elucidated the critical role of tumor cell-intrinsic mechanisms in …
Read PDFEstrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a coregulator of uterine estrogen signaling. …
Read PDFImmune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more severe infections and increased cancer rates, while women exhibit higher vaccine responses and prevalence …
Read PDFCancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the …
Read PDF<h4>Background</h4>Stroke is a complex, multidimensional disorder influenced by interacting inflammatory, immune, coagulation, endothelial, and metabolic pathways. Single-omics approaches seldom capture this complexity, whereas multiomics techniques provide complementary insights but generate high-dimensional and correlated feature spaces. …
Read PDFThe number of people seeking help for mental illness is increasing across all ages, creating a major burden for individuals, families, and the society. While personalized medicine is advancing in other fields, diagnosis and treatment …
Read PDFPrecision medicine is transforming hematologic cancer care by tailoring treatments to individual patient profiles and moving beyond the traditional "one-size-fits-all" model. This review outlines foundational technologies, disease-specific advances, and emerging directions in precision hematology. The …
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