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BACKGROUND: The lack of reliable screening biomarkers for prostate cancer (PC) diagnosis makes tissue biopsy the gold-standard strategy. However, its frequent inconclusive results often lead to repeated procedures, increasing patient burden and healthcare costs. In …
Read PDFDespite the epidemiological importance of triatomine bugs as vectors of Trypanosoma cruzi, mitogenomic resources remain limited for many lineages, restricting evolutionary and comparative analyses. The endemic Chilean genus Mepraia is a notable example, with scarce …
Read PDF<h4>Background/aim</h4>Hepatocellular carcinoma (HCC) exhibits substantial metabolic plasticity that supports tumor progression and therapeutic resistance. LGALS3BP has been primarily characterized as a secreted immunomodulatory protein; however, its cell-intrinsic role in regulating subcellular organization and metabolism in …
Read PDFBACKGROUND: As an important economic trait in ducks, residual feed intake (RFI) may be influenced by the intestinal microbiota. However, the mechanisms underlying microbiota-host crosstalk remain unclear. RESULTS: We analyzed the total egg number (TEN), …
Read PDF<h4>Background</h4>Virus mutants are commonly used for studying the role of individual viral proteins in infections and are increasingly investigated with functional genomics experiments of infected cells that use sequencing-based assays such as RNA-seq or ATAC-seq. …
Read PDFPathogenic DEGS1 variants have been reported in individuals with autosomal recessive hypomyelinating leukodystrophy 18 (HLD18; MIM# 618404). Here we describe three participants with HLD features and a previously unreported homozygous DEGS1 5' splice site variant, …
Read PDF<h4>Background</h4>Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and exhibits a high propensity for liver metastasis, often leading to poor prognosis. However, effective prognostic biomarkers and therapeutic strategies for metastatic UVM …
Read PDF[This corrects the article DOI: 10.3389/fmicb.2025.1714857.].
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Read PDFBACKGROUND: Fertility was impaired in sleep deprivation (SD) male rats. Dutasteride (DUT), a 5-α reductase inhibitor, also had negative effects on fertility, however, its definite mechanisms were still unknown. To this end, SD male model …
Read PDFTo elucidate the molecular mechanisms underlying grain size formation in barley, this study selected two distinct barley cultivars with significant differences in grain dimensions: the large-grained cultivar 'jianglinhuang' and the small-grained cultivar 'heiseyeqingke'. We conducted …
Read PDFThe medicinal plant Coptis chinensis is highly susceptible to root rot caused predominantly by Fusarium spp., threatening yield and medicinal quality. Biological control agents (BCAs) from the genus Bacillus are promising, yet their host mechanisms …
Read PDFTumor hypoxia is biologically important in breast cancer, but its prognostic value may be distorted by intrinsic molecular subtype composition. This study evaluated whether hypoxia-related prognosis was subtype-dependent and whether hypoxia was associated with genome-wide …
Read PDFCancer research has undergone a fundamental transformation in recent decades due to the integration of artificial intelligence (AI) models into the study of tumor biology. However, tumor evolution, driven by genetic and phenotypic alterations leading …
Read PDF<h4>Background</h4>Luminal B-like breast cancer (LBBC) constitutes approximately 40% of breast cancer cases and carries a higher risk of recurrence and poorer prognosis than luminal A-like disease. This study aimed to investigate the molecular alterations between …
Read PDFRetinoblastoma (RB) is the most prevalent malignant tumor that originates within the eye in children, occurring at a frequency of around 1:20,000 to 1:15,000. RB typically occurs when both alleles of the retinoblastoma 1 (RB1) …
Read PDFColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with tumor microenvironment (TME) heterogeneity playing a critical role in disease progression and therapeutic response. Immune escape (IE) mechanisms facilitate tumor evasion from host …
Read PDF<h4>Background</h4>Altered lipid metabolism is increasingly recognized as a driver of tumor progression, yet its specific role in thyroid cancer remains unclear.<h4>Methods</h4>We combined Mendelian randomization with transcriptomic and single-cell analyses to identify lipid-related factors that contribute …
Read PDF<h4>Background</h4>Pediatric cough-variant asthma is characterized by chronic airway inflammation and epithelial dysfunction driven by complex cellular interactions and molecular regulatory networks. Understanding the cellular heterogeneity and molecular mechanisms underlying pediatric asthma pathogenesis remains challenging. Single-cell …
Read PDFBACKGROUND: Aedes triseriatus is an endemic North American mosquito and the primary vector of La Crosse virus, the etiologic agent of La Crosse encephalitis. This neuroinvasive disease is the leading cause of arboviral encephalitis in …
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