Search the literature by keyword, topic, or author. Filter to articles with full text available.
2701 results
<h4>Background</h4>Spatial transcriptomics have emerged as a powerful tool in biomedical research because of its ability to capture both the spatial contexts and abundance of the complete RNA transcript profile in organs of interest. However, limitations …
Read PDFDespite significant advances in understanding lung development, the intricate cellular interactions and spatial organization of the developing human lung remain incompletely defined. Spatial transcriptomics enables gene expression profiling within the native tissue context, providing unprecedented …
Read PDF<h4>Background and objective</h4>Thymic epithelial tumors (TETs) are rare neoplasms originating from thymic epithelial cells (TECs). They exhibit histological, molecular, and immunological diversity shaped by aberrant interactions between neoplastic TECs and immune cells. World Health Organization …
Read PDFLung adenocarcinoma (LUAD) is a predominant subtype of lung cancer and is highly lethal. The lung tissue microbiota has been implicated in lung cancer biology but remains incompletely defined at early stages. We enrolled 40 …
Read PDFBACKGROUND: Next generation sequencing (NGS) has expanded virus detection capabilities beyond the limitations of sequence-specific methods. While mosquito collections in South Africa (SA) have been investigated for the major arbovirus genera (Alpha-, Orthobunya-, and Orthoflavivirus), …
Read PDFThis letter evaluates Deng <i>et al</i> study examining the gut microbiota and metabolite changes in metastatic colorectal cancer (CRC). The research used 16S rRNA sequencing and liquid chromatography-mass spectrometry metabolomics to investigate microbial and metabolic …
Read PDFUnderstanding the relative influence of immigration and species sorting in wastewater treatment systems is essential, as bacteria in influent wastewater can significantly impact treatment system functionality. This study investigated the contribution of immigration to the …
Read PDF<h4>Introduction</h4>Dryland ecosystems are increasingly exposed to extreme heat and prolonged water limitation. Facultative crassulacean acid metabolism (CAM) enables certain desert plants to enhance water-use efficiency and adjust carbon assimilation under stress conditions. <i>Mesembryanthemum forsskalii</i> Hochst. …
Read PDFMicro and nano-plastics pose a significant threat to the global environment, affecting agricultural systems, food security, and human health. Some studies indicate that microplastics can induce physiological damage in plants, including oxidative stress, reduced germination, …
Read PDFThe gut microbiota is recognized as a programmable metabolic organ that governs systemic homeostasis. Recent advances (2023-2025) have pivoted Type 2 Diabetes Mellitus (T2DM) research from a host-centric perspective toward a failure of bidirectional host-microbe …
Read PDFBovine respiratory disease (BRD) is a multifactorial syndrome and a leading cause of morbidity and economic loss in global cattle production. Next-generation sequencing (NGS) platforms, including Illumina and Oxford Nanopore Technologies (ONT), have enabled high-resolution …
Read PDFSpliced leader (SL) trans-splicing occurs in a wide range of eukaryotes and plays a critical role in processing mRNAs derived from operon structures. However, current research on this mechanism remains limited, partly due to the …
Read PDF<h4>Background</h4>The liverwort Apopellia endiviifolia, a dioicous, simple thalloid species, is notable for its cryptic diversity, habitat adaptability, and genomic innovation, and it represents a clade that is sister to all other Jungermanniopsida. These features make …
Read PDFThe human <i>ALKBH</i> gene family comprises nine Fe<sup>2+</sup>/α-ketoglutarate-dependent dioxygenases that catalyze the oxidative demethylation of DNA, RNA, and proteins, thereby influencing key cellular processes. Consequently, dysregulation of these enzymes has been implicated in various human …
Read PDF<h4>Background</h4>Basophils are implicated in various diseases including allergies, but a comprehensive single-cell characterization of human basophils has yet to be performed. Here, we aimed to generate a single-cell omics-based reference resource of circulating human basophils, …
Read PDFOff-white or yellowish shoots are common in tea plants (<i>Camellia sinensis</i> L.), and such albino variations are often accompanied by metabolic reprogramming, including increased contents of amino acids and lower levels of polyphenols. Nonetheless, the …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) is the third most common cancer globally. Alternative splicing contributes significantly to CRC tumorigenesis through aberrant transcript generation. However, the regulatory influence of RNA modifications on splicing remains poorly understood, largely due …
Read PDF<b>Background:</b> Medulloblastoma is the childhood tumor with the highest morbidity and mortality worldwide. This type of cancer is characterized by a high degree of heterogeneity that gives rise to different molecular groups with disparities in …
Read PDFAlternative splicing is a key regulator of immune regulation by enabling rapid and context-specific responses. However, the role of splicing regulators such as CDC-like kinase 1 (CLK1) in monocyte biology remains poorly defined. Here, we …
Read PDF