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Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD. The LC participates in feeding behavior …
Read PDFBACKGROUND: Recently, the heterogeneity of human papillomavirus (HPV) status within HPV-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) has garnered substantial attention. However, the origin and relevance of a subset of cancer cells with HPV-loss remain largely …
Read PDFBiomedical research models are undergoing continuous evolution, while conventional models (two-dimensional/ three-dimensional cultures and animal studies) face limitations in physiological relevance and ethical constraints. Against this backdrop, the integration of organ-on-a-chip (OoC) technology with multi-omics …
Read PDFWound healing is a dynamic and spatially heterogeneous process involving coordinated activity across multiple cell types. We analyze a high-resolution porcine wound-healing transcriptomic dataset of 150 samples from wound edges and centers collected across 15 …
Read PDFHepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, and its progression is closely linked to the establishment of an immunosuppressive tumor microenvironment. Myristoylated alanine-rich C kinase substrate (MARCKS) has been implicated in …
Read PDF<h4>Purpose</h4>Knee osteoarthritis (KOA) is a chronic degenerative joint disease and recognized as the fourth leading cause of disability worldwide. Despite the proven clinical efficacy of electroacupuncture (EA) in alleviating KOA-related symptoms, the precise molecular mechanisms …
Read PDF<h4>Background</h4>Hypopharyngeal squamous cell carcinoma (SCC) is an aggressive malignancy with a poor prognosis, particularly in advanced stages. Concurrent chemoradiotherapy (CCRT) is frequently employed to preserve the larynx, but resistance to CCRT remains a significant clinical …
Read PDF<h4>Background</h4>Immune exclusion is a major barrier to immune checkpoint inhibitor (ICI) efficacy in gastric cancer, yet the spatial mechanisms by which m<sup>6</sup>A regulators drive this phenotype remain unclear.<h4>Methods</h4>We integrated single-cell RNA-seq, spatial transcriptomics, and functional …
Read PDFINTRODUCTION: Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy of the kidney, known for its aggressive growth and tendency to metastasize. Cellular senescence (CS), regarded as a characteristic feature of the natural aging …
Read PDFMembers of <i>Geobacter sulfurreducens</i> are electroactive bacteria that transfer electrons to extracellular solid electron acceptors using extracellular electron transport (EET) pathways, thereby generating currents in bioelectrochemical systems (BESs). Studies have shown that different <i>G. sulfurreducens</i> …
Read PDF<h4>Background</h4>Tumor cell heterogeneity is a fundamental driver of breast cancer aggressiveness, underlying recurrence, metastasis, and therapy resistance. Understanding the biological characteristics and functions of specific tumor cell clusters in the tumor microenvironment is crucial for …
Read PDF<b>Background:</b> The therapeutic effect and mechanism of protocatechuic aldehyde (PAL) on vascular dementia (VaD) were studied from a multi-group perspective. <b>Methods:</b> The pharmacological property of PAL was assessed by using both an in vivo two-vessel …
Read PDFBACKGROUND: Sodium overload-induced cell death is a novel mode of cell death that differs from other modes and is a very promising new target for cancer therapy. In addition, sodium overload-induced cell death plays a …
Read PDFGlioblastoma invasion into brain parenchyma presents significant challenges for treatment but remains poorly understood. In this study, we combine single-cell RNA sequencing, spatial transcriptomics, and multiplexed imaging of orthotopic xenograft models to investigate glioblastoma invasion. …
Read PDF<h4>Background</h4>Although surgery and chemotherapy remain standard treatments for colorectal cancer (CRC), immunotherapy offers a promising avenue for patients with advanced disease. However, the cellular and molecular mechanisms underlying CRC progression and immune evasion are not …
Read PDFAlzheimer's disease is characterized by complex molecular and cellular heterogeneity, which complicates efforts to identify consistent biomarkers and therapeutic targets. To better characterize the heterogeneity, we applied latent factor modeling to RNA sequencing data from …
Read PDFThe increasing availability of transcriptomic data has created new opportunities for integrating gene expression studies across biological systems and conditions. However, differences in experimental design, sequencing platforms, and sample composition introduce substantial heterogeneity, limiting direct …
Read PDFCancer cell dormancy is a clinically consequential yet computationally under-defined phenomenon characterised by reversible growth arrest and delayed disease recurrence. Although advances in single-cell and multi-omic profiling have improved detection of dormant and persister populations, …
Read PDFHepatocellular carcinoma (HCC) is characterized by substantial heterogeneity and immune tolerance, and its therapeutic efficacy is profoundly influenced by the immune microenvironment. Ferroptosis, an iron-dependent form of regulated cell death, is closely linked to tumor …
Read PDFThe spatial organization of adaptive immune cells within lymph nodes is critical for understanding immune responses during infection and disease. Here, we introduce AIR-SPACE, an integrative approach that combines high-resolution spatial transcriptomics with paired, high-fidelity …
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