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A 4-dimensional spatial gene expression atlas of Hordeum vulgare (barley) grain development and germination was generated using spatial transcriptomic analysis of serial sections to reconstruct transcript abundance in 3 physical dimensions and with temporal kinetics. …
Read PDFThe main sources of circulating erythropoietin (Epo) in the adult are kidney Norn cells, a recently identified interstitial cell type capable of becoming renal Epo-producing (REP) cells following a local decrease in tissue oxygenation. REP …
Read PDF<b>Background</b>: Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) exhibit substantial heterogeneity, reflecting the diversity of the germinal center (GC). Histologic transformation of FL to DLBCL is associated with poor prognosis, yet robust biomarkers …
Read PDFDrought stress is a major constraint on global agriculture, exacerbated by climate change and increasing water scarcity. Conventional strategies such as breeding and genetic engineering have improved drought tolerance in crops, yet their scalability and …
Read PDF<h4>Background</h4>Obesity, a chronic metabolic disease, lacks effective treatments. Intermittent fasting (IF), especially time-restricted feeding (TRF), shows promise, yet the comparative molecular effects of different regimens remain unclear. This study examined their impact on 3T3-L1 adipocytes …
Read PDF<h4>Aim of the study</h4>To analyze the chemical components of BSCO, evaluate its effects on lung cancer through vivo and vitro experiments, reveal its underlying mechanism in a rat model of LC.<h4>Methods</h4>Ultra-high performance liquid chromatography with …
Read PDFAlzheimer's disease (AD) is characterized not only by neuronal dysfunction but also by profound remodeling of the brain microenvironment, including immune-glial activation and metabolic dysregulation. Increasing evidence also implicates neurosteroid-related pathways in AD and dementia. …
Read PDF<h4>Background & objective</h4>Emerging viral infections can initiate a global pandemic with high mortality. Understanding the immunopathogenesis of these viruses is critical to developing effective strategies for managing/preventing such outbreaks.<h4>Methods</h4>Transcriptomics analysis was performed in a UAE …
Read PDFHigh-throughput spatial transcriptomics (ST) now profiles hundreds of thousands of cells or locations per section, creating computational bottlenecks for routine analysis. Sketching, or intelligent sub-sampling, addresses scale by selecting small, representative subsets. While effective for …
Read PDF<b>Background:</b> Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by interconnected dysregulation of steroidogenesis and insulin signaling. Multi-target therapeutic strategies are increasingly needed to address its heterogeneous pathophysiology. <b>Methods:</b> An integrative approach combining …
Read PDFAdvances in organoid and other three-dimensional culture systems, single-cell and spatial transcriptomics, multi-omics, and high-resolution imaging are reshaping our understanding of the cellular origins and evolutionary trajectories of glioblastoma. When integrated with modern data science …
Read PDFNeutrophils are key first responders in the host response to <i>Clostridioides difficile</i> infection (CDI). Although a high number of tissue and blood neutrophils clearly correlates with adverse outcomes in CDI patients, their functional role remains …
Read PDFDiabetic kidney disease (DKD) lacks specific biomarkers reflecting the interplay between mitochondrial dysfunction and immune microenvironment remodeling. To address this, we integrated multi-dataset transcriptomics (GEO, MitoCarta 3.0, GeneCards) with Weighted Gene Co-expression Network Analysis, protein-protein …
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Read PDFBACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular heterogeneity and poor prognosis, necessitating novel tailored therapies. The basal and classical subtypes - driven by glycolysis versus lipid metabolism - have distinct prognostic implications warranting further …
Read PDFTemporomandibular joint (TMJ) arthritis remodels the cartilage, subchondral bone, and synovial tissue with diverse cell changes. The functional importance of the anatomical organization of TMJ cell types and cellular microenvironment in painful arthritis remains largely …
Read PDFAldosterone-producing adenomas (APAs) and micronodules (APMs) are histopathological lesions that can cause a prevalent form of secondary hypertension called primary aldosteronism. Using integrated single-cell/nucleus and spatial transcriptomics, it demonstrates substantial heterogeneity between APMs and APAs, …
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