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Female patients with ER<sup>+</sup>HER2<sup>-</sup> breast cancer have a favourable prognosis for 5-10 years. Later relapses are, however, common, yet predictions of late recurrence risk are suboptimal, particularly for patients with intermediate risk determined by the …
Read PDFAmbient temperature is a primordial determinant of longevity across the animal kingdom, yet the molecular transducers that couple thermal cues to aging rates remain elusive. Here, we interrogate the transcriptomic and metabolomic landscapes of Drosophila …
Read PDFLeonurine has been demonstrated to exert significant therapeutic effects against <i>Salmonella enteritidis</i> induced intestinal inflammation; however, its precise mechanism of action in combating <i>Salmonella</i> infection remains unclear. In this study, a <i>Salmonella</i> infection IEC6 cell …
Read PDFUnderstanding the temporal dynamics of gene expression within spatial contexts is essential for deciphering cellular differentiation. RNA velocity, which estimates the future state of gene expression by distinguishing spliced from unspliced mRNA, offers a powerful …
Read PDFSpatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights into gene and protein expression within their native tissue context. Unlike conventional bulk or single-cell sequencing approaches, spatial omics has the …
Read PDFGlial cells play a critical role in neural development, function, and immune regulation, with microglia serving as the principal immune cells of the central nervous system and retina. Although microglia are central to neuroinflammation and …
Read PDFAdvances in spatial transcriptomics have enabled high-resolution mapping of tissue architecture at the molecular level, yet integrating its multi-modal data remains challenging. Here, we present stGCL, a framework for accurate and robust integration of gene …
Read PDFAcute myeloid leukemia (AML) is a subtype of hematopoietic neoplasm affecting myeloid cells in blood and bone marrow. Molecular subtyping of AML provides in-depth insights into disease pathogenesis, facilitating clinical diagnostics and therapeutic management. While …
Read PDFBACKGROUND: Glioma is the most common malignant brain tumor, characterized by high heterogeneity and poor prognosis. Microtubule dynamics regulate tumor progression and immune escape; however, the prognostic significance of microtubule-associated genes in glioma and their …
Read PDF<h4>Background</h4>Salsola collina Pall. is a typical food-medicinal resource with considerable nutritional and medicinal value. However, systematic investigations into the dynamic changes in the chemical composition of the leaves of this species during the growth cycle …
Read PDF<h4>Background</h4>Oxidative stress (OS) is increasingly implicated in benign prostatic hyperplasia (BPH), yet the underlying cellular programs remain unclear. We integrated multi-omics and machine learning to identify OS-associated biomarkers and to characterize OS-linked stromal states, with …
Read PDFIgA nephropathy (IgAN) is the most prevalent type of primary glomerulonephritis, with heterogeneous clinical outcomes. Conventional prognostic factors, such as proteinuria, eGFR, and Oxford histologic classification, have poor sensitivity and specificity. Recently, transcriptomic profiling has …
Read PDFThe abnormal accumulation of hyperphosphorylated tau in neurofibrillary tangles is a hallmark of neurodegenerative diseases, such as Alzheimer's disease (AD) and frontotemporal dementia. In AD, tangle pathology characteristically develops in brain regions with heightened vulnerability, …
Read PDFSepsis is a life-threatening syndrome characterized by profound biological heterogeneity and dynamic immune dysregulation. Traditional uniform treatment strategies have failed to account for distinct immune endotypes ranging from hyperinflammation to immunoparalysis. Advances in transcriptomic, proteomic, …
Read PDFCancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) are pivotal stromal and immune components of the tumor microenvironment (TME) that orchestrate immune evasion, metabolic reprogramming, and therapeutic resistance. Regions enriched in CAFs are frequently accompanied by …
Read PDFAdvances in single-cell and spatial technologies have transformed the dissection of cell composition and tissue architecture in complex biological systems. However, identifying rare cells critical to disease pathogenesis and biological processes remains difficult, as their …
Read PDFTo identify the cell types that are infected with KSHV and the immune interactions in Kaposi sarcoma (KS) lesions, we performed spatial transcriptomics with seven KS skin tumors. We used a single-cell RNA-sequencing reference data …
Read PDFTumor heterogeneity and complex microenvironment interactions drive malignant progression and therapeutic resistance. Traditional omics technologies struggle to capture this complexity due to the loss of spatial molecular context. Spatial multi-omics technologies enable the simultaneous <i>in …
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