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<h4>Background</h4>Early detection of drug-induced liver injury (DILI) during drug development is crucial for reducing drug attrition and ensuring the safety of patients. A versatile, biologically interpretable, and dose-dependent screening approach is therefore needed to inform …
Read PDF<h4>Background</h4>Spatial transcriptomics (ST) technologies are reshaping our understanding of tissue organization and cellular context in health and disease. However, technical benchmarking across platforms remains limited, particularly in formalin-fixed, paraffin-embedded (FFPE) clinical samples, which represent the …
Read PDFSpatially resolved transcriptomics (SRT) measures transcriptomes of cells within intact biological tissues, providing unprecedented opportunities to investigate tissue micro-environments, where spatial domains are modeled as clusters of spatially neighboring cells. Current methods for the identification …
Read PDFLarge language models (LLMs) have demonstrated impressive capabilities in summarization, reasoning, and content generation, yet their inability to directly interpret large-scale omics data has limited their utility in data-driven hypothesis generation-particularly in mechanism discovery that …
Read PDFBACKGROUND: Transcriptome analysis is essential to dissect the molecular mechanisms underlying phenotypic differences and disease mechanisms. Traditionally, microarrays were used, but RNA sequencing (RNA-seq) has become a more powerful and reproducible alternative. RNA-seq is widely …
Read PDFBACKGROUND: Transcriptomic profiling technologies have advanced the analysis of biological and toxicological responses. However, substantial differences in probe design, dynamic range, gene coverage, and preprocessing pipelines across platforms introduce artifacts that limit cross-study integration and …
Read PDF<h4>Background</h4>Cervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood.<h4>Methods</h4>In this study, we performed an integrated spatial transcriptomic and metabolomic analysis of …
Read PDF<h4>Background</h4>Cervical cancer, as one of the most common types of malignant tumors in women, poses a significant threat to the health and survival of women worldwide. Tumor drug resistance has emerged as a critical bottleneck …
Read PDFPapillary thyroid carcinoma (PTC) undergoes dedifferentiation into aggressive poorly differentiated (PDTC) or anaplastic (ATC) carcinomas in 10–15% of cases, a process potentially driven by cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME), though their spatiotemporal …
Read PDFAmyloid beta (Aβ) plaque deposition in the central nervous system (CNS) is a hallmark of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), triggering robust innate immune responses. However, the role of the adaptive immune …
Read PDFAs one of the most evolutionarily complex and functionally diverse organs, the brain is characterized by its intricate structure, developmental alterations, and cellular heterogeneity. Although extensive brain atlases exist, there remains an urgent need for …
Read PDFAcute kidney injury (AKI) lacks targeted pharmacological interventions. While the DanShen-DaHuang (DS-DH) herb pair shows clinical potential for AKI treatment, and our prior study has validated its nephroprotective efficacy in a cisplatin-induced murine model, its …
Read PDFWang et al. identify CXCL10<sup>high</sup> TNFα<sup>high</sup> Ki67<sup>+</sup> microglia as drivers of CD8<sup>+</sup> T cell recruitment during experimental cerebral malaria (ECM). We propose a conservative reframing: rather than asserting a fully validated new taxonomy, CXCL10<sup>high</sup> microglia …
Read PDFOmics sciences are revolutionizing the field of biomedical and dental research by allowing for an integrated understanding of the molecular basis of health and disease. This narrative review analyzes the role of these novel technologies …
Read PDFPhotodynamic therapy (PDT) provides non-invasive precision for superficial lesions but achieves suboptimal responses in hypoxic tumors such as head and neck squamous cell carcinoma (HNSCC). Spatially heterogeneous resistance mechanisms pose a major translational constraint for …
Read PDFTo define the transcriptional features, spatial distribution, and immune-related properties of an antigen-presenting cancer-associated fibroblast (CAF)-like state in nonsmall cell lung cancer (NSCLC), and to evaluate its relationship with the nuclear factor erythroid 2-related factor …
Read PDFLiver cancer is one of the deadliest malignancies, with increasing incidence worldwide. Recent advances in immunotherapy have expanded the options for systemic therapy against advanced hepatocellular carcinoma (HCC), but there are no biomarkers currently available …
Read PDFCurrently, many widely used spatial transcriptomics (ST) technologies do not achieve single-cell resolution, with each spot capturing signals from multiple, potentially heterogeneous cells. As a result, a key challenge is to resolve the spatial distribution …
Read PDF<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by excessive fibroblast activation and extracellular matrix deposition, leading to severe tissue remodeling and poor prognosis. While current treatments offer limited efficacy. Emerging …
Read PDF<h4>Background</h4>Inflammatory bowel disease (IBD) is associated with energy deficiency and perturbed metabolism of the essential amino acid tryptophan (Trp).<h4>Objective</h4>We aimed to determine whether excessive Trp degradation fuels or compensates for inflammation through de novo nicotinamide …
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