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<h4>Background</h4>Severe COVID-19 is associated with dysregulated immune responses. Immune responses heterogeneity was previously reported during the first waves of the pandemic. We aimed to characterise mucosal transcriptomic profiles in critically-ill patients during the Omicron era.<h4>Methods</h4>This …
Read PDF<i>Thamnaconus septentrionalis</i> is an emerging commercially important aquaculture species in China, distributed extensively in the Indo-West Pacific Ocean. Recently, because of the seriously declining population and considerable economic potential of this aquaculture fish, increasing attention …
Read PDF<h4>Background</h4>Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However, the spatial and single-cell …
Read PDFHyperlipidemia is a major risk factor for cardiovascular disease, yet effective dietary interventions remain underexplored. Pomegranate (POG) has been recognized for its potential lipid-lowering effects, but its underlying mechanisms require further investigation. To elucidate the …
Read PDFChildhood is a critical period for hematopoietic development and susceptibility to hematologic disease. Here we generated a multimodal single-cell atlas of healthy human bone marrow, capturing mRNA and surface protein expression in 90,710 cells, including …
Read PDF<h4>Background</h4>Cancer-associated fibroblasts (CAFs) are increasingly recognized as critical contributors to the limited efficacy of immunotherapy, particularly through the establishment of immune-excluded tumor microenvironments. However, the functional heterogeneity and spatial ecological roles of CAFs in melanoma …
Read PDFIntercalary meristems (IcMs), specialized developmental zones that drive rapid stem elongation in monocots, exhibit distinct spatiotemporal dynamics; however, their genetic basis remains poorly understood due to their transient activity and cellular heterogeneity. Moso bamboo (<i>Phyllostachys …
Read PDFLnCeVar 2.0 (available at http://bio-bigdata.hrbmu.edu.cn/LnCeVar or http://www.bio-bigdata.net/LnCeVar) is an updated database investigating genomic variations that disrupt competing endogenous RNA (ceRNA) networks via single-cell and spatial transcriptomics. Enhancements include expanded data and improved features: (i) 16 …
Read PDFAdvances in cardiac regenerative medicine increasingly rely on integrating artificial intelligence with spatial multi-omics technologies to decipher intricate cellular dynamics in cardiomyocyte differentiation. This systematic review, synthetising insights from 88 PRISMA selected studies spanning 2015-2025, …
Read PDFSkin ulcerative disease (SUD) in sea cucumbers poses a significant threat to marine biodiversity, aquaculture sustainability, and ecosystem health. Characterized by localized lesions that can progress to extensive tissue necrosis, SUD arises from complex interactions …
Read PDFAlzheimer's Disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. Neuroinflammation drives AD progression and therefore represents a promising target for diagnosis and therapy. In early AD, microglia polarize into pro-inflammatory …
Read PDFHead and neck squamous cell carcinoma (HNSC) is an aggressive malignancy often resistant to therapy, especially in advanced stages. Metabolic reprogramming, marked by shifts in glycolysis and oxidative phosphorylation (OXPHOS), is crucial for tumor progression …
Read PDFGenetics strongly impacts the course of metabolic dysfunction-associated steatotic liver disease (MASLD), with the I148M <i>Patatin like phospholipase domain containing 3</i> (<i>PNPLA3</i>) variant representing the main modifier. Fat accumulation in the hepatic lobule, strongly enhanced …
Read PDFMaternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed …
Read PDFBlood transcriptomic signatures for Parkinson's disease (PD) diagnosis have failed to integrate into clinical practice despite decades of translational efforts. We evaluated the classification performance of 13 published coding RNA-based signatures using both a large …
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Read PDFSeed development is a pivotal stage of the soybean life cycle, directly determining yield and nutritional quality related to oil and protein contents. However, the spatiotemporal mechanisms underlying cell differentiation and nutrient accumulation during seed …
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