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<h4>Background</h4>Cirrhosis, particularly HBV-induced, poses a significant global health burden. This study compares immune cell landscapes in HBV and non-viral cirrhosis using single-cell RNA sequencing (scRNA-seq) to elucidate distinct immune mechanisms driving disease progression.<h4>Methods</h4>Liver tissues from …
Read PDFIκBζ (<i>NFKBIZ</i>) has been implicated as a key co-transcription factor in psoriasis pathogenesis. While its role in keratinocytes is well established, the involvement in dermal fibroblasts, another critical skin cell type, remains underexplored. This study …
Read PDFT cells are the central players in antitumor immunity, and effective tumor killing depends on their ability to infiltrate into the tumor microenvironment (TME) while maintaining normal cytotoxicity. However, late-stage tumors develop immunosuppressive mechanisms that …
Read PDF[This corrects the article DOI: 10.3389/fimmu.2025.1663251.].
Read PDFAcne vulgaris is a common skin condition involving complex interactions among lipid-secreting sebaceous glands, keratinocytes, immune cells, and microbiota. While retinoids are effective for treating acne, disease pathogenesis remains poorly understood. In particular, it remains …
Read PDFSpatial transcriptomics (ST) offers unprecedented opportunities to decode the spatial organization of gene expression, yet the inherent noise and complexity of ST data pose substantial challenges for accurate analysis. Here, we present DACN, a unified …
Read PDFSpatial transcriptomics (ST) links tissue morphology with gene expression values, opening new avenues for digital pathology. Deep learning models are used to predict gene expression or classify cell types directly from images, offering significant clinical …
Read PDFRegional brain atrophy has been observed in dementia with Lewy bodies (DLB), yet determinants of regional vulnerability remain unclear. Using imaging transcriptomics, we examined whether normative gene expression patterns relate to regional atrophy in DLB. …
Read PDF<h4>Background</h4>Commercial molecular classifiers such as Prediction Analysis of Microarray 50 (PAM50), Oncotype DX, and MammaPrint have revolutionized breast cancer management. However, their clinical reliability is undermined by tumor heterogeneity.<h4>Methods</h4>We quantified the discordance in clinical molecular …
Read PDF<h4>Introduction</h4>Breast cancer (BRCA) remains the leading cause of cancer-related mortality among women and poses significant therapeutic challenges. While the heterogeneity of the tumor microenvironment (TME) is well established as a key contributor to tumor progression …
Read PDFGlioblastoma (GBM) contains diverse immune and tumor cell populations whose spatial organization influences disease progression. To better understand how immune cells interact with brain tumor-initiating cells (BTICs), we applied integrated single-cell and spatial transcriptomic approaches …
Read PDFAdeno-associated virus (AAV)-based gene therapy for severe neurological diseases is challenged by immune responses, which are difficult to study accurately in genetically divergent rodent models or in in vitro human induced pluripotent stem cell (iPSC)-derived …
Read PDF<h4>Objective</h4>Triple-negative breast cancer (TNBC) exhibits pronounced intratumoral heterogeneity, and cancer stem cells (CSCs) are thought to play a pivotal role in this process. However, the molecular regulatory mechanisms linking CSC-associated stemness features to tumor progression …
Read PDF<h4>Background</h4>The pulmonary immune system orchestrates lung homeostasis and protects against environmental insults through coordinated actions of immune and structural cells. Traditional Chinese medicine recognized the functional interaction between the lungs and the large intestine more …
Read PDFSpatially variable genes (SVGs) are essential for elucidating tissue organization within spatially resolved transcriptomics. While a number of computational methods have been developed for SVG identification, their reliance on algorithm-specific assumptions, such as predefined kernel …
Read PDF<h4>Background</h4>Interferons play a central role in antiviral defense, but their dysregulation contributes to inflammation and immune dysfunction in respiratory viral infections, including COVID-19. While interferon-stimulated genes (ISGs) are essential effectors of this response, their expression …
Read PDF<h4>Objective</h4>This study aimed to develop and validate a machine learning model integrating multi-omics and radiomics data to improve diagnostic accuracy and identify potential biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD).<h4>Methods</h4>A total of 278 patients …
Read PDFAcne, the most prevalent inflammatory skin condition globally, lacks comprehensive understanding of its cellular and molecular mechanisms. This research integrates single-cell transcriptomics with spatial immunofluorescence to detail cellular composition and functional states in healthy skin, …
Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited efficacy of current therapies in advanced cases. As a key risk factor for HCC, liver fibrosis may influence tumor progression and immune responses. …
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