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<h4>Background</h4>Hypoxic-ischemic (HI) brain injury triggers a dynamic, multi-phase response involving early microglial efferocytosis followed by extracellular matrix (ECM) deposition and scar formation. Arginase-1 (ARG1), a key enzyme in tissue repair, is implicated in both processes, …
Read PDFThe human genome produces a large repertoire of non-coding RNAs (ncRNAs) with important regulatory roles in development, physiology, and most of diseases. Among these, long non-coding RNAs (lncRNAs) have emerged as key modulators of gene …
Read PDF<h4>Objective</h4>This study aimed to elucidate the functional role of Kininogen-1 (KNG1) in traumatic brain injury (TBI) and evaluate its potential as a therapeutic target.<h4>Methods</h4>A TBI rat model was established using a controlled cortical impact method. …
Read PDFThe bone marrow (BM) microenvironment plays a crucial role in regulating hematopoiesis, yet the molecular changes associated with aging in humans remain poorly understood. Using single-cell RNA sequencing, we uncovered transcriptional shifts in BM endothelial …
Read PDFGenome-wide association studies (GWAS) have identified a large number of variants linked to complex traits and diseases, most of which lie in noncoding regions and act in a tissue- and cell type-specific manner. However, how …
Read PDFRecurrent loss of complex traits such as insect flight offers insights into evolutionary regression, as seen in <i>Bombyx mori</i> domestication from its flight-capable ancestor <i>B. mandarina</i>. By integrating single-cell and spatial transcriptomics of developing flight …
Read PDFPeroxisomes are eukaryotic organelles primarily known for their conserved roles in fatty acid β-oxidation and hydrogen peroxide detoxification. These organelles are also involved in a diverse range of other metabolic and non-metabolic functions. We recently …
Read PDFInterstitial lung diseases (ILD) are characterized by fibrotic scarring of the lung parenchyma with remarkably unfavorable prognosis. Using single-nucleus RNA sequencing and spatial transcriptomics, we generated a comprehensive cellular network of the distal lung and …
Read PDFGrain feeding is used to alleviate grazing pressure on the Tibetan Plateau. This study employed metabolomics and transcriptomics to elucidate the regulatory mechanisms of grain feeding on yak (Bos grunniens) meat quality, intramuscular fat, and …
Read PDFDespite significant progress in targeted cancer therapies and conventional imaging methodologies, the effective detection and treatment of solid tumours remain a major clinical challenge. This is thought to be caused by the complexity and heterogeneity …
Read PDF<h4>Background</h4>Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder in women, hallmarked by hyperandrogenism, anovulation, and polycystic ovarian morphology. This study integrates multi-omics and machine-learning analyses to elucidate the molecular mechanisms and cellular constituents underlying …
Read PDFThe integration of multi-omics technologies with non-thermal food processing represents a paradigm shift from population-based to precision nutrition interventions. This review synthesizes current advances in genomics, transcriptomics, proteomics, metabolomics, and microbiomics alongside emerging non-thermal technologies, …
Read PDFGastric cancer (GC), of which cases with peritoneal metastasis are particularly challenging, retains its position of being highly complex and remarkably resistant to therapy. Understanding the spatial heterogeneity and leveraging recent technologies such as machine …
Read PDFRemodeling of the tumor microenvironment (TME) under therapeutic pressure is a critical determinant of treatment response and resistance in hepatocellular carcinoma (HCC). Triple-combination therapy integrating targeted agents, immune checkpoint inhibitors, and radiotherapy (T+I+R) has shown …
Read PDF<h4>Background</h4>Colorectal cancer (CRC) is a leading cause of cancer-related death, often marked by intratumoral heterogeneity, immune evasion, and therapeutic resistance. Recent advancements in single-cell and spatial transcriptomics have enabled a deeper understanding of the tumor …
Read PDFThoracic aortic aneurysm (TAA) is a life-threatening condition characterized by aortic dilation, inflammation, and extracellular matrix degradation. Despite advances in surgical management, effective pharmacological therapies are still lacking, largely due to an incomplete understanding of …
Read PDFMyocardial ischemia-reperfusion (MIR) injury is a major cause of cardiac dysfunction, but the spatial heterogeneity of its underlying molecular programs remains unclear. In this study, we applied Visium spatial transcriptomics to generate gene expression maps …
Read PDFExercise-induced secreted factors (exerkines) are proposed to coordinate systemic health benefits, yet their human tissue sources and the physiological rules governing transcript-to-serum coupling remain incompletely defined. We integrated multi-tissue transcriptomics with matched serial serum profiling …
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