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AXL, a receptor tyrosine kinase implicated in tumor progression, undergoes post-translational modifications that regulate its activity and stability. In this study, we demonstrated that AXL is extensively N-glycosylated in breast and ovarian cancer cells, existing …
Read PDFMycobacterium tuberculosis is the causative pathogen of human tuberculosis and a leading cause of death worldwide attributed to a single infectious agent. While small non-coding RNAs (sRNAs) have emerged as key regulators of bacterial pathogenicity, …
Read PDFNogo (RTN4) proteins and their receptors have emerged as candidate mediators of metabolic regulation and vascular pathology relevant to type 2 diabetes (T2D). The primary objective of this PRISMA-guided systematic review was to evaluate the …
Read PDF<b>Background/Objectives:</b> Doxorubicin (DOX) is an effective chemotherapeutic agent whose clinical utility is limited by cardiotoxicity. To investigate underlying mechanisms, we employed a multi-omics approach integrating transcriptomics and proteomics, leveraging established mouse models of chronic DOX-induced …
Read PDFAbdominal aortic aneurysm (AAA) remains difficult to detect early due to its silent progression and lack of reliable molecular biomarkers. Computational prioritization of disease-associated proteins from protein-protein interaction (PPI) networks offers a scalable alternative to …
Read PDF<h4>Background</h4>Tumor neoantigens are key targets for personalized vaccines and T-cell therapies, yet most pipelines focus on neoantigens derived from SNV/small indel and often yield a limited number of high-quality candidates. SVs are prevalent in tumors …
Read PDFNitric oxide (NO•) is an important regulatory molecule in many biological processes, including immune response. During response to classical activation stimuli lipopolysaccharide (LPS) and interferon-γ (IFNγ), macrophages generate NO• via inducible nitric oxide synthase (iNOS). …
Read PDFCell-cell communications are widely explored to understand tissue homeostasis and diseases. Numerous computational tools have been developed to infer cellular interactions from transcriptomic or proteomic expression data. However, proteins often carry post-translational modifications (PTMs) that …
Read PDF<h4>Background</h4>Circulating proteomics acts as an intermediate phenotype linking genetic susceptibility to MASLD. However, current evidence rarely establishes a direct concordance between serum protein levels and hepatic gene expression. We aimed to perform a multi-cohort joint …
Read PDFBACKGROUND: Metabolic rewiring plays a crucial role in the energy metabolism of hepatocytes during steatosis. However, the precise alterations in energy metabolism remain unclear. The aim of this study was to investigate the effects of …
Read PDFBoth the Apolipoprotein E (ApoE) genotype and apolipoprotein (Apo) profiling are closely associated with the risk of coronary heart disease (CHD). However, it remains unclear whether APOE genotypes modulate the distribution of Apos and whether …
Read PDF<h4>Purpose</h4>The purpose of this study was to determine how Pax6 haploinsufficiency alters epithelial maturation, immune balance, sensory innervation, and lacrimal function across the ocular surface, and how these defects affect corneal repair.<h4>Methods</h4>Pax6tm1Ued mice crossed with …
Read PDFSingle-cell proteomics (scP) is a crucial complement to transcriptomics, offering deeper insight into cellular heterogeneity, disease mechanisms, and therapeutic vulnerabilities in samples such as 2D cell culture, 3D models, and patient tissue. While transcriptomics enables …
Read PDFPhenotyping cells at transcriptomic and proteomic levels is an essential step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances modestly correlate, complementary profiling of both is needed. …
Read PDFTREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer's disease (AD). Genetic polymorphisms reducing expression of the functionally related protein CD33 are protective. Here we have contrasted cellular …
Read PDFMost studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their …
Read PDFProtein phosphorylation is a central post-translational modification regulating cellular signaling, frequently dysregulated in cancer. Mass spectrometry (MS)-based phosphoproteomics has emerged as a powerful approach to systematically profile phosphorylation events, thereby revealing aberrant kinase activity and …
Read PDF<h4>Background/aims</h4>Cholangiocarcinoma (CCA) is a primary malignant neoplasm with an extremely poor prognosis. While combined chemoradiotherapy has been demonstrated to delay CCA progression to a certain extent, the absence of specific molecular biomarkers or targets significantly …
Read PDFBACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease (ILD) with limited treatment options and poor prognosis. Differentiating IPF from connective tissue disease–associated ILD (CTD-ILD) is clinically challenging due to overlapping features, …
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