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Sex chromosomes have evolved independently many times across eukaryotes. Despite a considerable body of literature on sex chromosome evolution, the causes and consequences of variation in their formation, degeneration, and turnover remain poorly understood. Chromosomal …
Read PDFHighly inflammatory mononuclear phagocytes (MNPs) cause tissue damage across the respiratory tract and other organs in response to infections such as SARS-CoV-2. Extracellular vesicles (EVs) can metabolically and phenotypically reprogram target cells, suggesting a potential …
Read PDFContrast-induced acute kidney injury (CI-AKI) is a major cause of hospital-acquired AKI, but its molecular pathogenesis remains incompletely understood. In this study, we used quantitative 4D proteomics, integrating ion mass-to-charge ratio (m/z), retention time, ion …
Read PDFHidradenitis suppurativa (HS) is an autoinflammatory keratinisation disease affecting the pilosebaceous unit and hallmarked by a complex and multifactorial pathogenesis. Although genomic and transcriptomic investigations have substantially advanced our understanding of key mechanisms underlying HS …
Read PDFGlobal environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the …
Read PDFCancer biomarkers are now recognized as major tools for early detection, diagnosis, and prognosis. In the last 10 years or so, molecular biology, proteomics, and genomics have been rapidly advancing to find tissue-specific biomarkers used …
Read PDFHigh-throughput sequencing enables genome-wide interrogation of biological systems, yet prioritizing functionally relevant genes and proteins from these data remains a key challenge. Here, we present ExIR (experimental data-based integrative ranking), a data-driven framework that classifies …
Read PDFThe embryo establishes a body plan and primes itself for organogenesis during gastrulation. As gastrulation is challenging to study in vivo, stem-cell-derived 'gastruloids' have emerged as powerful surrogates. Although transcriptomics and imaging have been applied …
Read PDF<h4>Background</h4>Adenovirus 26 (Ad26) vector-based vaccines have shown immunogenicity and safety in various infectious disease settings. However, the impact of each vaccine component (vector/insert) on the immune response has yet to be explored in a controlled …
Read PDFRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovitis, in which fibroblast-like synoviocytes (FLSs) serve as the primary effector cells that drive the destruction of joints. Baicalin has previously demonstrated efficacy in …
Read PDF<h4>Background</h4>Tauopathies are neurodegenerative diseases all characterized by tau lesions in the brain. Nevertheless, a clinical and pathophysiological heterogeneity is present among them. This includes the dominant tau isoform found within aggregates (3R and/or 4R tau) …
Read PDFChronic kidney disease (CKD) is highly prevalent worldwide, yet structural kidney injury often develops long before changes in estimated glomerular filtration rate (eGFR) or persistent albuminuria are detected. Albuminuria is a well-established prognostic marker and …
Read PDF<h4>Objective</h4>Intervertebral disc degeneration (IDD) imposes substantial economic and healthcare burdens, yet its mechanisms remain incompletely understood and effective pharmacological treatments are lacking. This study aimed to elucidate key factors driving IDD progression, specifically investigating lysosomal …
Read PDFBACKGROUND: The uterus is a pivotal organ for mammalian reproduction, directly determining reproductive success by orchestrating embryo implantation, placental development, fetal nourishment, and parturition. However, the molecular mechanisms regulating high fecundity in the uterus across …
Read PDF<h4>Purpose</h4>To evaluate whether extending the postmortem interval (PMI) from 12 to 18 hours affects transcript and protein abundances in the human retina.<h4>Methods</h4>Donor eyes were recovered from postmortem donors (n = 7 pairs) and stored at …
Read PDFThe Hevea brasiliensis is the only commercial source of natural rubber. In natural rubber production, exogenous ethylene is widely used as a stimulant for increasing rubber latex yield. To reveal the potential regulation mechanisms for …
Read PDFDupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production …
Read PDFHuman embryonic stem cells (hESCs) provide a powerful in vitro model to study lineage specification and the regulatory programs underlying early human development. Here, we present a high-resolution, temporal multi-omics dataset tracking mRNA, translation, and …
Read PDFThe LIM kinases (LIMK1/2) are key mediators in signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X …
Read PDFType 1 diabetes is caused by autoimmune destruction of insulin-secreting β-cells within islets of Langerhans. Transplantation of donor islets can improve glycaemic control, but current clinical islet transplantation protocols are compromised by extensive loss of …
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