Search the literature by keyword, topic, or author. Filter to articles with full text available.
2701 results
The evaluation of therapeutic response is essential in disease monitoring both for disease status and treatment efficacy in inflammatory bowel disease. Here, we focused on the use of positron emission tomography directed towards granzyme B, …
Read PDF<h4>Background</h4>Oral cancer and oral potentially malignant disorders (leukoplakia and oral submucous fibrosis) are prevalent and clinically significant oral diseases. Actin, crucial for epithelial tissue integrity, undergoes cytoskeleton reorganization associated with increased invasiveness in oral cancer.<h4>Material …
Read PDFHigh mobility group AT-hook 1 (HMGA1) is a chromatin regulator overexpressed in various cancers, often predicting poor outcomes. However, its role in head and neck squamous cell carcinoma (HNSCC) remains unclear. A hallmark of HNSCC …
Read PDFNutritional studies in the cattle typically focus on the rumen and its microbial environment, leaving other parts of the gastrointestinal (GI) tract largely unexplored. Thus, underlying molecular mechanisms and the responses to dietary treatment in …
Read PDFTherapeutic use of electroconvulsive shock (ECS) is particularly effective for treatment-resistant depression. Like other more common forms of antidepressant treatment, such as SSRIs, ECS has been shown to increase neurogenesis in the hippocampal dentate gyrus …
Read PDFNon-small cell lung cancer (NSCLC) exhibits disparate responses to anti-angiogenic therapies between its two major histologic subtypes, lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), suggesting a histotype-dependent angiogenesis regulation. Tumor-associated fibroblasts (TAFs) exhibit an …
Read PDFEP300, a frequently mutated transcriptional coactivator in bladder cancer, has been demonstrated to positively correlate with malignancy in various cancers. Highly aggressive bladder cancers are often associated with muscle-invasive progression, a process closely linked to …
Read PDFOver the past decade, thousands of putative human RNA-binding proteins (RBPs) have been identified, increasing the need for methods that define their RNA-binding capacities across diverse biological settings. Existing methods rely either on antibody-based in …
Read PDFStrawberry ripening is non-climacteric, and post-harvest fruit enter senescence and deteriorate rapidly. Chilled storage induces transcriptome-wide changes in gene expression, including down-regulation of aroma-related genes. Histone marks are associated with transcriptional activation or repression; the …
Read PDF<h4>Objectives</h4><i>Gentiana macrophylla</i> Pall. (Gentianaceae) is a medicinally important perennial herb. Iridoids are the main chemical constituents of <i>G. macrophylla.</i> The scarcity of the wild resource has led to increased attention to cultivated <i>G. macrophylla</i>. However, …
Read PDFInherited retinal degenerations, such as retinitis pigmentosa, are a leading cause of irreversible vision loss, yet broadly effective treatments remain elusive. Impaired cellular waste clearance via autophagy-lysosomal pathways have been implicated in photoreceptor death, but …
Read PDFMaturing human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in vitro is critical for advancing drug discovery and cardiotoxicity screening applications of these cells. However, the metabolic compositions of basal media used for hPSC-CM culture typically offer …
Read PDFAdeno-associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 10<sup>11</sup>and 10<sup>15</sup> viral …
Read PDF<i>Neisseria gonorrhoeae</i> (Gc) is the gram-negative bacterium that causes gonorrhea, a prevalent sexually transmitted infection that can have life-threatening clinical sequelae. Gc requires iron for human infection and uses the iron-responsive, iron-binding transcriptional repressor Fur …
Read PDFThe genetic code is one of the most highly conserved features across life. Only a few lineages have deviated from the "universal" genetic code. Amongst the few variants of the genetic code reported to date, …
Read PDFThe recent surge in plant genomic and transcriptomic data has laid a foundation for reconstructing evolutionary scenarios and inferring potential functions of key genes related to plants' development and stress responses. The classical scheme for …
Read PDFUnderstanding the ecological adaptation of tree species can not only reveal the evolutionary potential but also benefit biodiversity conservation under global climate change. <i>Quercus</i> is a keystone genus in Northern Hemisphere forests, and its wide …
Read PDFThough the phylogenetic signal of loci on sex chromosomes can differ from those on autosomes, chromosomal-level genome assemblies for nonvertebrates are still relatively scarce and conservation of chromosomal gene content across deep phylogenetic scales has …
Read PDFA myelination is essential for neural function in the vertebrate central nervous system, yet the molecular details of how the oligodendrocyte differentiation program has evolved remain poorly understood. Here, we performed a cross-species single-cell transcriptomic …
Read PDFEmerging fungal pathogens are a global challenge for humankind. Many efforts have been made to understand the mechanisms underlying pathogenicity in bacteria, and OMICs techniques are largely responsible for those advancements. By contrast, our limited …
Read PDF