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Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ-specific control. We hypothesised that phenotypic variation …
Read PDFEquine herpesvirus type 1 (EHV-1) is a high morbidity and mortality virus that impacts horse populations worldwide. As a respiratory virus, it enters through the upper respiratory tract (URT), where mucosal immunity plays a crucial …
Read PDF<b>Background/Objectives</b>: Combinations of PARP inhibitors (PARPi) and androgen receptor pathway inhibitors (ARPi) have led to clinical success in treating advanced prostate cancer. However, it is unclear where in the clinical paradigm these combinations will fare …
Read PDFColibacillosis caused by Avian Pathogenic Escherichia coli (APEC) is a major threat to poultry, and yolk sac infection is a leading cause of embryonic mortality. However, the molecular mechanisms and host responses during the infection …
Read PDFB cell receptor (BCR) signaling is required for the regulation of normal B lymphocyte development. However, many B cell lymphoma subtypes employ constitutive BCR signaling for transformation, survival, and growth. Here we report that mice …
Read PDFFlower color is a key ornamental trait in Nobile-type <i>Dendrobium</i>, yet the molecular basis underlying purple flower formation remains poorly understood. In this study, a white-flowered paternal cultivar and its purple-flowered filial line were used …
Read PDFGenome-wide association studies (GWASs) have identified many sources of genetic variation associated with bone mineral density (BMD), a clinical predictor of fracture risk and osteoporosis. Aside from the identification of causal genes, other difficult challenges …
Read PDFThe amount of soluble inorganic phosphate (Pi) in soils is typically low and limiting plant growth. Roots of trees in several forest ecosystems form association with ectomycorrhizal (ECM) fungi, where fungi forage and supply inorganic …
Read PDF3' single-cell RNA sequencing (scRNA-seq) captures polyadenylation (poly(A)) sites, enabling quantification of site usage per gene and cell. Here, we present scPASU (single-cell poly(A) site usage), a Snakemake workflow for quantifying poly(A) site usage and …
Read PDF<h4>Background</h4>Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA), an RNA-binding protein associated with HCC survival, emerges as a key regulator requiring mechanistic study.<h4>Methods</h4>To delineate SNRPA's functions, we generated SNRPA-overexpressing HepG2 cells and performed RNA-seq to identify SNRPA-regulated …
Read PDF<i>Brassica napus</i> a cool-season oilseed crop, is an important source of edible oil and biofuel. Heat stress during the reproductive stage poses a serious threat to its productivity, but little is known about the gene …
Read PDFBovine paratuberculosis (PTB), caused by <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP), is a chronic granulomatous intestinal disease that leads to substantial economic losses in the global dairy industry. Current diagnostic tests have limited sensitivity, as they …
Read PDFHistone methylation plays a pivotal role in the epigenetic regulation of fungal development. In this study, we characterise FgJhd2, a homologue of the histone demethylase Jhd2 from the JARID family, in the plant pathogenic fungus …
Read PDF<h4>Background</h4>Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucially, EndMT is a linchpin underlying several cardiometabolic diseases, but is almost universally studied …
Read PDFBACKGROUND: FLASH radiotherapy, characterized by ultra-high dose rates (> 40 Gy/s), potentially spares normal tissues while maintaining antitumor efficacy (the FLASH effect). While electron and proton FLASH are explored, pulsed X-ray sources like plasma focus …
Read PDFHypertrophic cardiomyopathy (HCM) is a common genetic heart disease, with macrophages playing a critical role in its pathological remodeling. Our study aims to investigate the molecular basis of HCM by analyzing macrophage-related gene expression at …
Read PDF<h4>Background</h4>Osteoarthritis (OA) is characterized by chronic inflammation, cellular senescence, and progressive cartilage remodeling, yet effective disease-modifying therapeutic targets remain limited. Caspase-8 has classically been regarded as a key initiator of the extrinsic apoptotic pathway; however, …
Read PDF<h4>Background</h4>Inflammatory response plays a pivotal role in myocardial injury and post-infarction remodeling after acute myocardial infarction (AMI). Mechanical unloading (UL) of the left ventricle (LV) has been proposed as a potential therapeutic strategy to preserve …
Read PDFBACKGROUND: Mammary gland development and lactation are dynamic biological processes governed by coordinated changes in chromatin accessibility and gene expression. RESULTS: We performed paired ATAC-seq and RNA-seq profiling to characterize stage-associated chromatin accessibility and transcriptional …
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