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<h4>Objective</h4>Atherosclerosis remains a leading cause of global morbidity and mortality despite cholesterol-lowering drugs and risk factor management. In mice, the absence of coagulation factor XI (FXI) on an apolipoprotein E (apoE)<sup>-/-</sup> genetic background has been …
Read PDF<i>Fusarium</i> wilt, caused by <i>Fusarium oxysporum f.</i> sp. <i>vasinfectum 7</i> (FOV7), poses a major threat to the production of elite Sea Island cotton (<i>Gossypium barbadense</i>). To uncover the molecular basis of defense FOV7 in cotton, …
Read PDFGenerating condition-specific metabolic models by mapping gene expression data to genome-scale metabolic models (GEMs) is a routine approach to elucidate disease mechanisms from a metabolic perspective. On the other hand, integrating variants that perturb enzyme …
Read PDFEndocrine cells are dedicated to the production and processing of hormones, from peptides to small molecules, to regulate key physiological processes, including glucose homeostasis and metabolism. Because of this relatively high productivity, endocrine cells must …
Read PDFAutophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role …
Read PDFCucumber (<i>Cucumis sativus</i> L.) is a globally significant vegetable crop, and its fruit quality remains a major focus of research. The hollow-heart trait, characterized by internal cracks or cavities, severely compromises both the commercial value …
Read PDF<h4>Background</h4>The emergence of flaviviruses and other arboviruses in novel geographic locations, arthropod vectors, and vertebrate amplification hosts complicates control and eradication efforts. Many flaviviruses continue to impact global health, including Zika virus (ZIKV) which has …
Read PDFPorcine epidemic diarrhea virus (PEDV) infection leads to serious intestinal disease in piglets, often leading to high mortality rates and substantial economic losses. Understanding host-PEDV interactions is crucial for PEDV therapeutic strategies. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation …
Read PDF<h4>Background</h4>Serrated neoplasia arises from serrated precursor lesions. Hyperplastic polyps commonly activate MAPK signalling, initiated by BRAF or KRAS mutation, but premalignant KRAS-mutant sessile serrated lesions are rare. Here, we model Kras- and Braf-mutant neoplasia in …
Read PDFPeritoneal dialysis (PD) is limited by insufficient phosphate removal, leading to adverse cardiovascular outcomes in patients with chronic kidney disease. To advance the understanding of the molecular mechanisms of peritoneal phosphate transport, RNAseq data of …
Read PDFAlthough safflower (Carthamus tinctorius L.) is a momentous medicinal and industrial crop with intrinsic stress tolerance, molecular mechanism response to drought stress at the transcriptome level has been rarely scrutinized. Here, comprehensive transcriptome analysis was …
Read PDFDigestive cancers exhibit high heterogeneity and poor prognosis, yet whether their tumor microenvironments share conserved stromal-immune interactions remains unclear. Here, we performed an integrative multi-omics analysis across seven digestive cancer types and identified a conserved …
Read PDF<h4>Background</h4>Identifying safe and broad-spectrum antiviral and anti-inflammatory agents remains an urgent need in infectious and inflammatory diseases. Here, we demonstrated that MNS (NSC170724), a small-molecule nitrovinyl benzodioxole, enhanced antiviral defense while limiting excessive inflammation.<h4>Methods</h4>The antiviral …
Read PDFSingle-cell RNA sequencing inadequately predicts protein abundance, particularly for intracellular cytokines. We developed CIPHER-seq (Cytokine Intracellular Protein High-throughput Expression with RNA-sequencing), enabling simultaneous quantification of intracellular proteins and transcriptomes. This system provides five layers of …
Read PDFComparing organ-specific gene regulatory networks (GRNs) across large evolutionary distances remains a major challenge, particularly when the species under study differ in data resolution. This applies to the GRN controlling compound eye development in insects, …
Read PDFIn the whole laying cycle, the late laying phase is the longest segment, and it directly determines total egg production and influences the timing of culling. To investigate the mechanisms underlying the decline in egg-laying …
Read PDFThe antitumoral activity of monoamine receptor ligands appears to be important as a potential approach to cancer medication. In the present study, we evaluated the effects of trace amine compounds, including octopamine, tyramine, 3-methoxytyramine, and …
Read PDFPea aphids can develop alternative morphs when exposed to stressful conditions, showing differences between genotypes in their stress responses. Although several biological pathways regulating alternative morph production have been investigated, the role of epigenetic mechanisms …
Read PDFRegulatory circuits driving regional cell fate specification and lineage restriction decisions are not fully understood. The molecular mechanisms by which Hedgehog signaling controls lineage segregation in the posterior foregut remain unclear. Here, we employed bulk …
Read PDFDorsal root ganglion (DRG) neurons have a wide range of functions, including touch, pain and itch. These neurons have recently emerged as promising targets for non-invasive focused ultrasound (FUS) neuromodulation. However, our understanding of the …
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