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<h4>Background</h4>Bats possess a uniquely adapted immune system that enables them to live with viral infections without the expected maladies. The molecular basis and regulation of bats' immune response is still not fully understood. Long non-coding …
Read PDFBreast cancer remains a significant global health challenge due to its complexity, which arises from multiple genetic and epigenetic mutations that originate in normal breast tissue. Traditional machine learning models often fall short in addressing …
Read PDFThe aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor activated by environmental toxicants like halogenated and polycyclic aromatic hydrocarbons, which then binds to DNA and regulates gene expression. AHR is implicated in numerous physiological …
Read PDFSingle-cell RNA sequencing (scRNA-seq) studies have uncovered distinct cancer-associated fibroblast (CAF) populations. While useful as a biological framework, no studies have conclusively defined CAF subtypes with clinical significance. We define restraining (rest) and promoting (pro) …
Read PDFThe neurodegenerative disorder frontotemporal dementia (FTD) can be caused by a repeat expansion (GGGGCC; G4C2) in C9orf72. The function of wild-type C9orf72 and the mechanism by which the C9orf72-G4C2 expansion causes FTD, however, remain unresolved. …
Read PDFCell polarity is essential for maintaining intestinal epithelial organization and function. Here we show that combined loss of polarity by epithelial loss of Cdc42 with oncogenic Kras expression in mice causes small intestine failure leading …
Read PDFEngineering the genetic code-by reassigning multiple of the 64 natural codons-enables making organisms resistant to all viruses, preventing genetic information exchange, and allowing the biosynthesis of genetically encoded unnatural polymers. However, synonymous codon replacement-recoding-is frequently …
Read PDFThe increasing frequency and severity of High Nighttime Temperature (HNT) threatens to damage rice quality by inducing the chalky grain phenotype. To better understand the roles that small RNAs (sRNAs) play in HNT-induced chalkiness in …
Read PDFTriple-negative breast cancer (TNBC) exhibits heterogeneous treatment responses, yet molecular subtypes based on predefined biological pathways show limited prognostic value. We introduce tumor-specific total mRNA expression (TmS), a pathway-agnostic deconvolution metric derived from matched RNA/DNA …
Read PDFIn this study, we systematically analyzed the dynamic changes in chromatin accessibility and the transcriptional responses in the spleen of largemouth bass (<i>Micropterus salmoides</i>) following infection with iridovirus (LMBV) using the assay for transposase-accessible chromatin …
Read PDFSkeletal muscle development, orchestrated by muscle stem cells (MuSCs), is a critical determinant of meat yield and quality in cattle. Transcription factors (TFs) are pivotal regulators of MuSCs fate, yet their specific roles in meat …
Read PDFNonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway known to degrade mRNAs containing premature termination codons (PTCs). mRNA recognition by the Upf1, Upf2 and Upf3 NMD factors is favoured by long distances between …
Read PDFThe Mycobacterium tuberculosis (Mtb) VapC4 endoribonuclease toxin exclusively cleaves and inactivates tRNACys, which leads to extensive ribosome stalling at Cys codons. Serendipitously, the precise position of stalled ribosomes is revealed within our 5' RNA-seq datasets …
Read PDF<h4>Background</h4>Given the ecological importance of reef-building corals (Scleractinia), it is perhaps surprising that the molecular mechanisms underlying many of the morphological and metabolic changes during their development remain unclear. In part, this is due to …
Read PDFWheat yellow rust - caused by Puccinia striiformis f. sp. tritici (Pst) - is the most damaging wheat rust in Europe, where three distinct races (Kalmar, Amboise and Benchmark) recently became prevalent. Herein, comparative genomic …
Read PDF<h4>Problem</h4>Natural killer (NK) cells are critical regulators of immune balance at the maternal-fetal interface. T-bet (Tbx21) is a key transcription factor shaping NK cell effector functions, yet its role in decidual NK (dNK) cell adaptation …
Read PDF<h4>Objective</h4>The Clitoria ternate flowers are widely used for its anthocyanin pigmentation. However, the flowers' colour ranges from white to light blue to deep blue, purple or even pink. The butterfly pea flower colours are known …
Read PDFYAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyze YAP1's role in regulating the pluripotency of the mammalian epiblast, using scRNAseq …
Read PDFThe human heart, originating from the splanchnic mesoderm, is the first functional organ to develop, co-evolving with the foregut endoderm through reciprocal signaling. Previously, cardioid models offered new insights on cardiovascular cell lineages and tissue …
Read PDFFertilization ensures the flow of information from the parent to the progeny via fusion of male and female gametes orchestrated by a cascade of events guided by parental noncoding RNA (ncRNA) molecules. These parental ncRNAs …
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