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<h4>Background</h4>Gastrointestinal (GI) malignancies, including gastric and colorectal cancers, remain one of the primary contributors to cancer-related illness and death globally. Despite the availability of conventional diagnostic tools, early detection and personalized treatment remain significant clinical …
Read PDFBACKGROUND: Disentangling physiopathological mechanisms of biological systems through high-level integration of omics data has become a standard procedure in life sciences. However, platform heterogeneity, batch effects, and the lack of unified methods for single- and …
Read PDFB cell malfunction is implicated in the pathogenesis of systemic lupus erythematosus (SLE) through the release of proinflammatory cytokines and the production of autoreactive antibodies. RNA N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the predominant post-transcriptional RNA modification that …
Read PDFChromatin accessibility is crucial in regulating gene expression and maintaining cellular identity. While single-cell RNA sequencing has revolutionized transcriptomic profiling, the understanding of chromatin dynamics across diverse tissues remains limited. Here, we use single-cell Assay …
Read PDF<h4>Purpose</h4>Omics technologies, such as genomics, transcriptomics, proteomics, and radiomics, play an increasingly important role in the diagnosis and treatment of non-small cell lung cancer (NSCLC). It is, therefore, essential to unveil the research landscape and …
Read PDFChronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic and therapeutic approaches usually fail to account for disease heterogeneity, resulting in low efficacy. Precision …
Read PDFMulti-omics (genomics, transcriptomics, epigenomics, proteomics, metabolomics, etc.) research approaches are vital for understanding the hierarchical complexity of human biology and have proven to be extremely valuable in cancer research and precision medicine. Emerging scientific advances …
Read PDFBiliary tract cancer (BTC) is a highly heterogeneous and aggressive gastrointestinal malignancy, marked by a high mortality rate and limited treatment efficacy. The primary contributing factors include the absence of reliable early detection methods, the …
Read PDFRespiratory diseases often result from complex interactions between an individual's genetic predisposition and their exposure to various environmental and other risk factors. Here we will briefly review how various types of "omics", particularly epigenomics and …
Read PDFRecent advances in molecular phenotyping have driven the rapid growth of untargeted, multi-dimensional approaches such as epigenomics, transcriptomics, proteomics, and metabolomics. When applied to ecology, these high-throughput omics tools offer powerful new molecular trait descriptors …
Read PDFVirus infections in plants are a major threat to crop production and sustainable agriculture, which results in significant yield losses globally. The past decade has seen the development and deployment of sophisticated high-throughput omics technologies …
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Read PDFImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with acute interstitial nephritis (ICI-AIN) being the most common irAE. While the exact mechanism remains unclear, upregulation of IFN-γ and TNF-α pathways has been implicated. …
Read PDFThe advancement of multi-omics tools has revolutionized the study of complex biological systems, providing comprehensive insights into the molecular mechanisms underlying critical traits across various organisms. By integrating data from genomics, transcriptomics, metabolomics, and other …
Read PDFIn recent years, single-cell RNA sequencing (scRNA-seq) has marked significant strides in livestock and poultry research, especially when integrated with multi-omics approaches. These advancements provide a nuanced view into complex regulatory networks and cellular dynamics. …
Read PDFPreeclampsia is a complex, hypertensive pregnancy disorder which is linked to an increased cardiovascular disease risk in both mothers and their offspring. Maternal haemodynamic adaptation during gestation is essential for adequate foetal nutrient supply and …
Read PDFIschemic stroke is a complex, multifactorial disorder with a significant heritable component. Recent developments in genome-wide association studies (GWASs) have identified several common variants associated with clinical outcomes, stroke subtypes, and overall risk. Key loci …
Read PDFGlucocorticoids are primary stress hormones necessary for life that act on nearly every tissue in the body to maintain homeostasis. These hormones and their synthetic derivatives are widely used in the clinic to combat disease …
Read PDFThe elucidation of actionable, tumor-specific neoantigens remains a challenge in cancer immunotherapy. We identify <i>FGGY</i>-204, an alternatively spliced isoform of <i>FGGY</i>, as a source of tumor-specific neoantigen presentation. <i>FGGY</i>-204 expression is elevated in HCC and …
Read PDFNeuropsychiatric interest in the relationship between glucose metabolism and criminal behavior dates back nearly a century. In particular, hypoglycemia was thought to play a causative role in some criminal acts, especially non-planned incidents involving impulsivity …
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