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Endometriosis is characterized by progressive fibrosis and limited therapeutic options. Cuproptosis, a copper-dependent form of regulated cell death, has been implicated in multiple pathological conditions, but its relevance to fibroblast-mediated fibrotic progression in endometriosis remains …
Read PDF<h4>Background</h4>Giant juvenile fibroepithelial tumors of the breast are rare lesions that mainly affect adolescent girls. Their pathogenesis is poorly understood, and current management relies almost entirely on surgery, which may interfere with breast development. To …
Read PDF<h4>Background</h4>Immunometabolic remodeling is central to sepsis, yet robust glycolysis-associated biomarkers and their cell-type context remain unclear.<h4>Methods</h4>We integrated peripheral blood scRNA-seq (GSE175453) and a whole-blood microarray cohort (GSE100159). Glycolysis activity was scored by AUCell (HALLMARK_GLYCOLYSIS), hub …
Read PDF<h4>Background</h4>Alopecia areata (AA) is an autoimmune hair loss disorder. Although autoreactive CD8<sup>+</sup> T cells are central effectors, the roles of stromal and epithelial compartments in sustaining inflammation remain unclear.<h4>Methods</h4>This study analyzed publicly available scRNA-seq data …
Read PDF<h4>Background</h4>Guttate psoriasis (GP) is associated with streptococcal throat infection. Neutrophils are the first immune cells to respond to Group A Streptococcal (GAS) infection, but detailed analysis of their contribution to GP pathogenesis is lacking. The …
Read PDF<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that has increasingly been associated with dysregulated mitochondrial quality control and dynamics. However, the molecular mechanisms underlying these alterations remain incompletely understood. This study aimed …
Read PDFThe tree shrew is a potential mammalian model for preclinical studies, but its immune system is not well understood. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to construct a comprehensive cell atlas of …
Read PDFThe mechanisms that underlie protective immunity to Mycobacterium tuberculosis (Mtb) remain incompletely defined. To identify immune correlates associated with protection, we performed single-cell RNA sequencing of lung immune cells after aerosol Mtb infection of naïve …
Read PDFHigh-grade serous ovarian cancer (HGSC) accounts for more than 70% of ovarian cancer-related deaths, yet therapeutic progress remains stagnant. Among the four molecular subtypes reported for HGSC, the C5 subtype is distinguished by high proliferation …
Read PDFDiffuse intrinsic pontine glioma (DIPG) is the pediatric tumor with the worst prognosis. BIOMEDE was a randomized phase 2 trial comparing the efficacy in terms of overall survival (OS) (primary endpoint) of epidermal growth factor …
Read PDF<h4>Background</h4>Endometriosis is a gynecological disorder that affects 190 million reproductive age women worldwide. Laparoscopic surgery is considered the gold standard to diagnose the disease, creating a barrier to diagnosis and leading to long delays in …
Read PDFOver the past few decades, it has become increasingly clear that small RNAs (sRNAs) play important regulatory roles in bacteria. These RNA species often work in concert with RNA chaperones such as Hfq that facilitate …
Read PDFStudying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an essential role in degrading plant biomass and can …
Read PDFCancer subtype classification is critical for precision therapy, and there is a growing trend to augment histopathology testing with omics-based machine learning classifiers. However, analytical challenges remain in pediatric cancer regarding the scope and precision …
Read PDF<h4>Introduction</h4>Sepsis is a life-threatening organ dysfunction syndrome with persistently high global mortality, driven by dysregulated host immune response. Existing single-target therapies fail to simultaneously address hyperinflammation and impaired tissue repair, leading to limited clinical efficacy …
Read PDFHistone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, …
Read PDFBACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid tumor with poor prognosis. Existing prognostication systems rely on clinical staging, but systems of tumor classification through molecular signatures and the association between cancer-associated fibroblast (CAF) …
Read PDFIntramuscular fat (IMF) is a pivotal determinant of meat quality in yaks (<i>Bos grunniens</i>). While nutritional factors are well-documented, the epigenetic landscape, particularly the transcriptional architecture governed by super-enhancers (SEs), remains largely unexplored in the …
Read PDFRNA regulation plays a central role in neurodevelopment by coordinating neuronal differentiation, migration, and circuit formation. The CUGBP Elav-like family member 2 (CELF2) is an RNA-binding protein with established roles in alternative splicing and mRNA …
Read PDFPeripheral blood mononuclear cells (PBMCs) represent a critical component of the immune system, orchestrating both cellular and humoral responses while maintaining immunological homeostasis. This study investigates the PBMC immune response to Pasteurella multocida (P. multocida) …
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