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<h4>Background</h4>Ulcerative colitis (UC) is a chronic, multifactorial inflammatory bowel disease. The involvement of small GTPase-related genes (SGRGs) in UC remains poorly defined. This study aims to identify SGRGs associated with UC and elucidate the molecular …
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Read PDFSevere fever with thrombocytopenia syndrome (SFTS), caused by <i>Dabie bandavirus</i> (DBV), triggers aberrant immune activation and cytokine storms, contributing to poor prognosis; however, its immune dysfunction mechanism remains unclear. Current management relies on symptomatic treatment …
Read PDF<h4>Background</h4>Cancer cachexia leads to decreases in body mass, lean mass and fat mass, decreased therapeutic potential and ~20% of cancer-related deaths. While several studies have demonstrated changes to components of the muscle microenvironment with cancer …
Read PDFCraniosynostosis is a common defect in the craniofacial structure of children, yet its pathogenesis remains unclear. Current research focuses mainly on bone-related genetic mutations, with less emphasis on lipid metabolism disorders. Hence, it is imperative …
Read PDF<h4>Background</h4>Endometriosis (EM) is associated with immune dysregulation, while dysfunction of natural killer (NK) cells is regarded as a key mechanism underlying immune escape and the persistent growth of ectopic lesions.<h4>Method</h4>This study used single-cell RNA sequencing …
Read PDF<h4>Objective</h4>Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks. Single-cell combined spatial transcriptomics …
Read PDF<h4>Background</h4>Immune checkpoint inhibitor-associated myocarditis (ICIAM) poses significant challenges for cancer immunotherapy, particularly regarding the safety and efficacy of immune checkpoint blockade (ICB) rechallenge.<h4>Methods</h4>The present study analyzed 23 cases of ICIAM by integrating longitudinal clinical data …
Read PDFFunctional genomics screens in human induced pluripotent stem cells (hiPSCs) remain challenging despite their transformative potential. We developed iPS2-seq: an inducible, clone-aware screening platform that enables phenotype-agnostic, single-cell resolved dissection of loss-of-function effects in hiPSC …
Read PDFAlzheimer's disease (AD) is a common neurodegenerative disorder; however, its molecular complexity remains poorly understood. Single-cell analysis can reveal the molecular changes in AD in different types of brain cells. In this study, we integrated …
Read PDF<h4>Background</h4>Single-cell RNA sequencing has emerged as a powerful approach to reveal cellular heterogeneity within biological systems. With the continuous advancement of high-throughput sequencing technologies, studies are generating vast amounts of complex data, posing a significant …
Read PDFCondyloma acuminatum (CA), primarily caused by low-risk HPV6/11, is a benign proliferative disease that is difficult to cure and prone to recurrence. However, the molecular and immune mechanisms underlying relapse remain unclear. We combined metabolomic …
Read PDF<h4>Background</h4>Pyroptosis, an inflammatory form of programmed cell death, contributes to intestinal inflammation in inflammatory bowel disease (IBD), but the key cell types and regulatory genes remain unclear.<h4>Methods</h4>We analyzed single-cell RNA-seq data from intestinal mucosa to …
Read PDFCellular and molecular characterization of mammals with multi-chambered stomachs is crucial to our understanding of evolution in digestive and metabolic systems. Here, we generate single-cell transcriptomic atlases of 253,448 and 279,057 cells from 54 tissues …
Read PDFThe rapid advancement of multi-omics single-cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution. However, many existing analysis tools are complex, requiring substantial coding expertize, which can be a …
Read PDFZirconia (ZrO<sub>2</sub>) has become a promising alternative to titanium (Ti) for bone implants due to its excellent biocompatibility. Despite this, the osseointegration of ZrO<sub>2</sub> remains lower than that of Ti implants. However, the underlying biological …
Read PDFThe accumulation of mitochondrial DNA (mtDNA) deletion mutants in post-mitotic cells is a hallmark of mammalian ageing and a key contributor to tissue decline in skeletal muscle and neurons. A transcription-coupled replication model predicts that …
Read PDFElucidating the mechanisms underlying vascular injury and repair may guide development of therapies against vascular cognitive impairment and dementia (VD). We employed single-cell RNA sequencing to map cell populations and explore vascular responses in mouse …
Read PDFThe inflammation-intestinal metaplasia (IM)-carcinoma cascade has been proposed as a framework for gastric cancer (GC) development, yet the cell-level heterogeneity and microenvironmental remodeling underlying this progression remain poorly characterized. Here, we constructed a single-cell transcriptomic …
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