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Large-scale single-cell genomics projects have revolutionized our understanding of human immune variation. Yet most studies to date have been Eurocentric, limited in cell-type resolution, or restricted to a single data modality. The newly published Chinese …
Read PDFArtificial intelligence (AI) is increasingly used in cancer research, enabling integrative analysis of complex biomedical data to identify actionable therapeutic vulnerabilities. This review specifically examines how AI advances mechanistic cancer target discovery and translational drug …
Read PDFBACKGROUND: Kelch repeat F-box (KFB) proteins are substrate-recognition components of SCF (SKP1-CULLIN1-F-box) E3 ubiquitin ligases and play important roles in protein turnover, specialized metabolism, and stress responses in plants. However, the evolutionary history of the …
Read PDFBACKGROUND: Qinchuan cattle, renowned for their distinctive meat quality, flavor, and exceptional environmental adaptability, represent a highly valuable genetic resource in beef cattle breeding. However, the molecular mechanisms underlying the formation of its meat quality …
Read PDFBreeding root, tuber, and cereal crops faces the critical challenge of unlocking extensive genetic variation and addressing complex gene-environment interplays to boost yield, quality, and resilience. Recent technological advances in pangenomics, multi-omics data integration, and …
Read PDF<h4>Background</h4>Piroplasmosis, including Theileriosis and Babesiosis, poses a threat to livestock health and productivity worldwide. However, the molecular mechanisms underlying breed-specific differences in resistance to piroplasmosis remain poorly understood. Compared to Bos taurus, Bos indicus generally …
Read PDF<h4>Background/aim</h4>Previous studies suggest that thyroid cancers in the isthmus are associated with more aggressive behavior and unfavorable patient outcomes compared to lobar tumors. This study aimed to characterize the molecular features of isthmus thyroid cancer.<h4>Materials …
Read PDFDeep learning frameworks have been developed for interpreting single-cell RNA sequencing (scRNA-seq) data and have demonstrated excellent performance across a range of tasks. However, existing methods remain limited in their ability to characterize heterogeneity at …
Read PDFOlfaction is important in ticks' host-seeking and mating behaviors, as it enables them to detect volatile chemical compounds. This scoping review aims to systematically map and synthesize the existing literature on olfactory gene families in …
Read PDFThe rapid growth of genome sequencing has outpaced the development of efficient annotation tools, especially for species lacking transcriptome data. To address this challenge, we present QuickProt, a fast, accurate and user-friendly homology-based protein annotation …
Read PDFSingle-cell RNA sequencing (scRNA-seq) is a powerful tool for characterising the immune landscape. Multiple technologies are available, each with distinct specificities and inherent biases. Here, we focus on two technologies-10X Genomics and Parse Biosciences-for the …
Read PDFDeep learning, as a pivotal branch of machine learning, has demonstrated remarkable potential in advancing crop science by effectively integrating genomics and phenomics. This review systematically outlines the application of diverse deep learning architectures-such as …
Read PDFThis review delves into brain imaging genomics, an interdisciplinary field merging brain imaging, genomics, and additional biomarkers with clinical data. The primary aim is to uncover new insights into the brain's phenotypic, genetic, and molecular …
Read PDFSystems biology approaches have contributed to advancing our understanding of complex respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). This systematic review evaluates the application of systems biology methodologies in respiratory medicine, focusing …
Read PDF<h4>Background</h4>Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with complex genetic underpinnings. Understanding the causal relationships between genetic factors and AML risk is crucial for developing targeted therapeutic strategies.<h4>Methods</h4>We conducted a comprehensive Mendelian randomization …
Read PDFIn their recent publication, Alblooshi et al. report the identification and preliminary functional analysis of a novel LACC1 variant, p.Asp220Asn, associated with familial juvenile idiopathic arthritis. While their study provides a valuable genetic association, this …
Read PDF<h4>Background</h4>Amphibians are among the most vulnerable vertebrates, with 41% of assessed species at risk of extinction. The genus Oophaga has most of its species currently listed as threatened by the IUCN. Oophaga vicentei, an endangered …
Read PDFGenome sequencing (GS) often reveals non-coding variants of uncertain significance, especially those predicted to affect pre-mRNA splicing. We present an integrative workflow combining splice prediction, a minigene assay and long-read RNA sequencing to assess their …
Read PDFThe common octopus, Octopus vulgaris, is renowned for its advanced nervous system and complex behavior, yet its immune system remains poorly understood despite its relevance for health and pathogen resistance. Understanding octopus immunity is key …
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