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The human body contains ~27-37 trillion cells of up to 10,000 cell types (CTs) within a volume of ~62-120 liters (males) and 52-89 liters (females). The Human Reference Atlas (HRA) v2.3 provides a quantitative 3D …
Read PDFThe brain is sustained by an intricate vascular network that provides a continuous supply of nutrients and oxygen essential for its function. Understanding the structural variability and region-specific function of this neurovascular system is essential …
Read PDF<h4>Purpose</h4>Small intestinal neuroendocrine tumors (SI-NET) frequently present as multifocal lesions, but the molecular mechanisms underlying their development and heterogeneity remain unclear. This study aimed to characterize the phenotypes of tumor cell populations across anatomic sites …
Read PDFHigh-resolution spatial transcriptomics (HR-ST) technologies offer unprecedented insights into tissue architecture but lack standardized frameworks for histological annotation. We present ST2HE, a cross-platform generative framework that synthesizes virtual hematoxylin and eosin images directly from HR-ST …
Read PDFThyroid cancer (TC), the most prevalent endocrine malignancy worldwide, encompasses a broad spectrum of biological behaviors ranging from indolent microcarcinomas to lethal anaplastic variants. Despite advancements in standard care, critical clinical "bottlenecks" persist, including the …
Read PDFFinding correlations in spatial gene expression is fundamental in spatial transcriptomics, as co-expressed genes within a tissue are linked by regulation, function, pathway, or cell type. Yet, sparsity and noise in spatial transcriptomics data pose …
Read PDFSuccessful generation of high-quality spatial transcriptomics data from murine musculoskeletal tissues has been impeded by the challenge of preserving RNA integrity through the harsh tissue processing steps required for histological sectioning. In particular, the need …
Read PDFIschemic stroke mobilizes adult neural stem cells (NSCs), which could be leveraged for recovery. However, the intercellular signals that activate NSCs are poorly understood. Cells located in the cerebral lesion may send signals to the …
Read PDF<h4>Introduction</h4>Abnormal cellular metabolism is one of the characteristics of tumour cells. However, the differences in the global metabolomics between normal and tumour tissues remain unclear. In this study, we have proposed a diagnostic and prognostic …
Read PDFWhile traditional imaging techniques, such as histopathology, are often part of clinical workflows, molecular profiling remains more difficult to conduct and is less cost-effective. Thus, the prediction of molecular 'omics' data directly from imaging has …
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Read PDF<h4>Background</h4>Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy characterized by marked cellular and spatial diversity within the tumor microenvironment (TME). The transforming growth factor-β (TGF-β) signaling pathway plays a dual role in the initiation and …
Read PDF<h4>Introduction</h4>Metastatic or locally advanced cutaneous squamous cell carcinoma (cSCC) that is not amenable to local therapy is treated with programmed death-1 (PD-1) inhibitors. Although response rates are relatively high, there are no validated predictive biomarkers …
Read PDFClassic RNA sequencing dissociates cells from their native tissue architecture, discarding spatial information that critically shapes transcriptional programs in development, homeostasis, and cancer. However, current ST platforms often produce incomplete and noisy profiles due to …
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Read PDFBACKGROUND: Rett Syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the MECP2 gene. Despite its monogenic nature, the molecular events contributing to RTT pathogenesis are not fully elucidated. METHODS: We applied a …
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